Human body morphology, prevalence of nasopharyngeal potential bacterial pathogens, and immunocompetence handicap principal

2014 ◽  
Vol 26 (3) ◽  
pp. 305-310 ◽  
Author(s):  
Boguslaw Pawlowski ◽  
Judyta Nowak ◽  
BARBARA Borkowska ◽  
Zuzanna Drulis-Kawa
Keyword(s):  
Human Body ◽  
Bacterial Pathogens ◽  
Body Morphology ◽  
Handicap Principal

Honour, Shame, and Bodily Mutilation. Cutting off the Nose among Tribal Societies in Pakistan

2006 ◽  
Vol 16 (3) ◽  
pp. 243-260 ◽  
Author(s):  
Jürgen Wasim Frembgen
Keyword(s):  
Human Body ◽  
Social Practice ◽  
Vantage Point ◽  
Colonial Period ◽  
Colonial Discourse ◽  
Body Morphology ◽  
Social Customs ◽  
Tribal Societies

Bodily mutilations, such as nose-cutting, are recorded worldwide from different cultural settings. Hence the custom is not solely an example of “Oriental violence and cruelty” (at times quoted in Orientalist sources from the colonial period). I want to emphasise that I am not arguing from the vantage point of a colonial discourse with its criticism of “degenerate and barbaric” social customs. Instead, this paper deals with the human body as a symbol of society. It is particularly focused on the symbolic significance of nose-cutting and on understanding this violent impulse as a social practice. The underlying notion is that cultural categories, such as “honour” and “shame”, are encoded in body morphology and affect behaviour.

scholarly journals PPE Surface Proteins Are Required for Heme Utilization by Mycobacterium tuberculosis

mBio ◽  
2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Avishek Mitra ◽  
Alexander Speer ◽  
Kan Lin ◽  
Sabine Ehrt ◽  
Michael Niederweis
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Human Body ◽  
Iron Acquisition ◽  
Bacterial Pathogens ◽  
Surface Proteins ◽  
Resonance Spectroscopy ◽  
Heme Uptake ◽  
Human Host ◽  
Essential Nutrient ◽  
Growth Experiments

ABSTRACT Iron is essential for replication of Mycobacterium tuberculosis, but iron is efficiently sequestered in the human host during infection. Heme constitutes the largest iron reservoir in the human body and is utilized by many bacterial pathogens as an iron source. While heme acquisition is well studied in other bacterial pathogens, little is known in M. tuberculosis. To identify proteins involved in heme utilization by M. tuberculosis, a transposon mutant library was screened for resistance to the toxic heme analog gallium(III)-porphyrin (Ga-PIX). Inactivation of the ppe36, ppe62, and rv0265c genes resulted in resistance to Ga-PIX. Growth experiments using isogenic M. tuberculosis deletion mutants showed that PPE36 is essential for heme utilization by M. tuberculosis, while the functions of PPE62 and Rv0265c are partially redundant. None of the genes restored growth of the heterologous M. tuberculosis mutants, indicating that the proteins encoded by the genes have separate functions. PPE36, PPE62, and Rv0265c bind heme as shown by surface plasmon resonance spectroscopy and are associated with membranes. Both PPE36 and PPE62 proteins are cell surface accessible, while the Rv0265c protein is probably located in the periplasm. PPE36 and PPE62 are, to our knowledge, the first proline-proline-glutamate (PPE) proteins of M. tuberculosis that bind small molecules and are involved in nutrient acquisition. The absence of a virulence defect of the ppe36 deletion mutant indicates that the different iron acquisition pathways of M. tuberculosis may substitute for each other during growth and persistence in mice. The emerging model of heme utilization by M. tuberculosis as derived from this study is substantially different from those of other bacteria. IMPORTANCE Tuberculosis is caused by Mycobacterium tuberculosis and is a devastating disease affecting eight million people each year. Iron is an essential nutrient for replication of M. tuberculosis in the human host. More than 70% of iron in the human body is bound in heme. Not surprisingly, many bacterial pathogens, including M. tuberculosis, are able to acquire iron from heme. However, the mechanism of heme uptake by M. tuberculosis is poorly understood. We have identified two novel surface proteins that bind heme and are required for heme utilization by M. tuberculosis. These findings constitute a major advancement of our understanding of iron acquisition by M. tuberculosis and show that M. tuberculosis has evolved heme uptake systems different from the paradigms established by other bacteria. IMPORTANCE Tuberculosis is caused by Mycobacterium tuberculosis and is a devastating disease affecting eight million people each year. Iron is an essential nutrient for replication of M. tuberculosis in the human host. More than 70% of iron in the human body is bound in heme. Not surprisingly, many bacterial pathogens, including M. tuberculosis, are able to acquire iron from heme. However, the mechanism of heme uptake by M. tuberculosis is poorly understood. We have identified two novel surface proteins that bind heme and are required for heme utilization by M. tuberculosis. These findings constitute a major advancement of our understanding of iron acquisition by M. tuberculosis and show that M. tuberculosis has evolved heme uptake systems different from the paradigms established by other bacteria.

scholarly journals Use of Human Body Morphology as an Indication of Physical Fitness: Implications for Police Officers

2018 ◽  
Vol 36 (4) ◽  
pp. 1407-1412 ◽  
Author(s):  
Filip Kukic ◽  
Milivoj Dopsaj ◽  
Jay Dawes ◽  
Robin Orr ◽  
Aleksandar Cvorovic
Keyword(s):  
Physical Fitness ◽  
Human Body ◽  
Police Officers ◽  
Body Morphology

Study on Making Human Morphological Thinking Mode Software with Founder Author Tool

2011 ◽  
Vol 268-270 ◽  
pp. 1466-1469
Author(s):  
Zhi Wei Chen ◽  
Hong Bo Yao ◽  
Hui Yu Xu
Keyword(s):  
Medical Students ◽  
Peer Review ◽  
Human Body ◽  
Student Survey ◽  
Body Morphology ◽  
Learning Efficiency ◽  
New Thinking ◽  
Thinking Mode ◽  
Human Systems

To improve medical students’ understanding of human body morphology and stimulate their interest in learning with the nine human systems as the center anatomy, histology and embryology, pathology as the whole. Founder Author Tool was used to make human morphological thinking mode software applied in teaching. Through peer review, student survey and feedback on teaching results, the course ware was evaluated. Founder Author Tool used to make human morphological thinking mode soft ware could obtain good results in teaching and won favorable feedback from students. This new thinking mode software used in teaching helps greatly in bettering medical students’ understanding of human body morphology, stimulating their interest in learning and improving the learning efficiency.

The Diagnosis of Viral Disease by Electron Microscopy

1982 ◽  
Vol 40 ◽  
pp. 270-273
Author(s):  
William B. McCombs ◽  
Cameron E. McCoy
Keyword(s):  
Electron Microscopy ◽  
Hospital Stay ◽  
Viral Infections ◽  
Medical Profession ◽  
Bacterial Pathogens ◽  
Viral Disease ◽  
Viral Pathogens ◽  
Academic Interest ◽  
The Past

Recent years have brought a reversal in the attitude of the medical profession toward the diagnosis of viral infections. Identification of bacterial pathogens was formerly thought to be faster than identification of viral pathogens. Viral identification was dismissed as being of academic interest or for confirming the presence of an epidemic, because the patient would recover or die before this could be accomplished. In the past 10 years, the goal of virologists has been to present the clinician with a viral identification in a matter of hours. This fast diagnosis has the potential for shortening the patient's hospital stay and preventing the administering of toxic and/or expensive antibiotics of no benefit to the patient.

Microstructural comparison of synthetic bioceramics with natural bioceramics

1991 ◽  
Vol 49 ◽  
pp. 38-39
Author(s):  
Shulin Wen ◽  
Jingwei Feng ◽  
A. Krajewski ◽  
A. Ravaglioli
Keyword(s):  
Recent Work ◽  
Human Body ◽  
Human Tissues ◽  
Main Constituent ◽  
Laboratory Furnace ◽  
Chinese Adult ◽  
Human Enamel ◽  
Biological Compatibility ◽  
Synthetic Hydroxyapatite ◽  
Synthetic Work

Hydroxyapatite bioceramics has attracted many material scientists as it is the main constituent of the bone and the teeth in human body. The synthesis of the bioceramics has been performed for years. Nowadays, the synthetic work is not only focused on the hydroapatite but also on the fluorapatite and chlorapatite bioceramics since later materials have also biological compatibility with human tissues; and they may also be very promising for clinic purpose. However, in comparison of the synthetic bioceramics with natural one on microstructure, a great differences were observed according to our previous results. We have investigated these differences further in this work since they are very important to appraise the synthetic bioceramics for their clinic application.The synthetic hydroxyapatite and chlorapatite were prepared according to A. Krajewski and A. Ravaglioli and their recent work. The briquettes from different hydroxyapatite or chlorapatite powders were fired in a laboratory furnace at the temperature of 900-1300°C. The samples of human enamel selected for the comparison with synthetic bioceramics were from Chinese adult teeth.

Study on erythrocytes by SEM photogrammetry (SEMP) technique

1990 ◽  
Vol 48 (3) ◽  
pp. 724-725
Author(s):  
Tong Wensheng ◽  
Lu Lianhuang ◽  
Zhang Zhijun
Keyword(s):  
Quantitative Analysis ◽  
Cell Membrane ◽  
Clinical Diagnosis ◽  
Human Body ◽  
Blood Cells ◽  
Three Dimensional ◽  
Normal Person ◽  
Blood Disease ◽  
Computation Technique ◽  
Important Basis

This is a combined study of two diffirent branches, photogrammetry and morphology of blood cells. The three dimensional quantitative analysis of erythrocytes using SEMP technique, electron computation technique and photogrammetry theory has made it possible to push the study of mophology of blood cells from LM, TEM, SEM to a higher stage, that of SEM P. A new path has been broken for deeply study of morphology of blood cells.In medical view, the abnormality of the quality and quantity of erythrocytes is one of the important changes of blood disease. It shows the abnormal blood—making function of the human body. Therefore, the study of the change of shape on erythrocytes is the indispensable and important basis of reference in the clinical diagnosis and research of blood disease.The erythrocytes of one normal person, three PNH Patients and one AA patient were used in this experiment. This research determines the following items: Height;Length of two axes (long and short), ratio; Crevice in depth and width of cell membrane; Circumference of erythrocytes; Isoline map of erythrocytes; Section map of erythrocytes.

Partial characterization and post-feeding activity of midgut aminopeptidase in the human body louse,Pediculus humanus humanus

1998 ◽  
Vol 23 (4) ◽  
pp. 382-387 ◽  
Author(s):  
James O. Ochanda ◽  
Eva A. C. Oduor ◽  
Rachel Galun ◽  
Mabel O. Imbuga ◽  
Kosta Y. Mumcuoglu
Keyword(s):  
Human Body ◽  
Feeding Activity ◽  
Partial Characterization ◽  
Body Louse ◽  
Pediculus Humanus ◽  
Post Feeding ◽  
Human Body Louse
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