Peripheral neuropathy in IgM monoclonal gammopathy and wäldenstrom's macroglobulinemia: A frequent complication in elderly males with low MAG-reactive serum monoclonal component

1994 ◽  
Vol 45 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Luca Baldini ◽  
Edoardo Nobile-Orazio ◽  
Andrea Guffanti ◽  
Sergio Barbieri ◽  
Marinella Carpo ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Monoclonal Gammopathy ◽  
Waldenström’S Macroglobulinemia ◽  
Frequent Complication ◽  
Elderly Males ◽  
Waldenstrom's Macroglobulinemia ◽  
Waldenstrom’S Macroglobulinemia ◽  
Waldenström's Macroglobulinemia ◽  
Monoclonal Component

scholarly journals Waldenstrom’s Macroglobulinemia and Peripheral Neuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes with a Bleeding Diathesis and Rash

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
S. Haider ◽  
T. Latif ◽  
A. Hochhausler ◽  
F. Lucas ◽  
N. Abdel Karim
Keyword(s):  
Bone Marrow ◽  
Peripheral Neuropathy ◽  
Monoclonal Gammopathy ◽  
Poems Syndrome ◽  
Waldenström’S Macroglobulinemia ◽  
Excessive Bleeding ◽  
Skin Changes ◽  
Waldenstrom's Macroglobulinemia ◽  
Waldenstrom’S Macroglobulinemia ◽  
Waldenström's Macroglobulinemia

We report a case of a 29-year-old male who presented with paraesthesia and skin lesions with excessive bleeding after skin biopsy leading to hematology consultation. He was found to have prolonged partial thromboplastin time (PTT) and monoclonal gammopathy on serum protein electrophoresis (SPEP). He experienced excessive bleeding leading to hospitalization after bone marrow biopsy and required blood transfusion. He was diagnosed with Waldenstrom's Macroglobulinemia (WM), based on the presence of IgM-κtype monoclonal (M) protein and infiltration of lymphoplasmacytic cells identified in bone marrow aspirates. He was noticed to have features of peripheral neuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS syndrome). This is a very rare case of WM with POEMS syndrome which responded to chemotherapy using bortezomib, steroids, and rituximab.

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