scholarly journals Upfront unrelated donor Hematopoietic stem cell transplantation in patients with idiopathic aplastic anemia: a retrospective study of the Severe Aplastic Anemia Working Party of European Bone Marrow Transplantation

2021 ◽  
Author(s):  
Audrey Françoise Petit ◽  
Austin G. Kulasekararaj ◽  
Dirk‐Jan Eikema ◽  
Alexey Maschan ◽  
Dalila Adjaoud ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Retrospective Study ◽  
Bone Marrow Transplantation ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Aplastic Anemia ◽  
Working Party ◽  
Unrelated Donor ◽  
Hematopoietic Stem

scholarly journals Development of hematopoietic stem cell transplantation at the Clinic of hematology, Clinical Center of Vojvodina in Novi Sad

2017 ◽  
Vol 70 (suppl. 1) ◽  
pp. 7-12
Author(s):  
Dusan Pejin
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Bone Marrow Transplantation ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Aplastic Anemia ◽  
Marrow Transplantation ◽  
Hematopoietic Stem ◽  
Hematological Diseases ◽  
Novi Sad

Hematology underwent substantial development in the second half of the 20th century. Research into the possibility of treating affected experimental animals with bone marrow transplantation was initiated at that time. Successful treatment of leukemia in animals by giving them chemo- and radiation therapy and subsequent administering of the bone marrow of a healthy animal showed to the clinicians the way to apply transplantation in humane medicine. The first allogeneic bone marrow transplantation in a patient suffering from acute leukemia was done in the United States by Prof. E. D. Thomas in 1957 after radiation of the entire body and chemotherapy with cytostatic agents. The patient?s destroyed bone marrow was successfully recovered by a voluntary HLA identical donor. This first experience encouraged numerous hematologists so they prepared themselves for a new era of treating malignant and benign hematological diseases. The Clinic for Hematology in Novi Sad gained its first experiences in 1977 when a patient with severe aplastic anemia successfully received, for the first time in our country, the bone marrow transplant from his twin brother. After extensive preparations at the Clinic for Hematology, in 1990, bone marrow and hematopoietic stem cell transplantation from blood became a standard method of treating malignant and benign hematological diseases. By 1999, the transplant team successfully performed 20 transplantations, 4 in patients with severe aplastic anemia, and 16 in patients with malignant hematological diseases which were unresponsive to standard therapy such as leukemia, myelodysplastic syndrome, multiple myeloma. Donors were HLA identical relatives, twins in two patients. The best results were achieved in all patients with aplastic anemia and in four patients with malignant hematological diseases, while in others the transplantation had a monthslong transient effect. Our experiences, as well as experiences across the world and Europe, were invaluable. New recommendations were given, narrowing down indications for allogeneic transplantation and the treatment has been focused on autologous transplantation and new anti-tumor drugs.

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