scholarly journals The International Hemoglobinopathy Research Network ( INHERENT ): an international initiative to study the role of genetic modifiers in hemoglobinopathies

2021 ◽  
Author(s):  
Petros Kountouris ◽  
Coralea Stephanou ◽  
Natasha Archer ◽  
Fedele Bonifazi ◽  
Viviana Giannuzzi ◽  
...  
Keyword(s):  
Research Network ◽  
Genetic Modifiers ◽  
International Initiative

scholarly journals The International Hemoglobinopathy Research Network (INHERENT): An International Initiative to Study the Role of Genetic Modifiers in Hemoglobinopathies

Blood ◽  
2021 ◽  
Vol 138 (Supplement 1) ◽  
pp. 948-948
Author(s):  
Petros Kountouris ◽  
Coralea Stephanou ◽  
Natasha M. Archer ◽  
Fedele Bonifazi ◽  
Viviana Giannuzzi ◽  
...  
Keyword(s):  
Sample Size ◽  
Board Of Directors ◽  
Research Funding ◽  
Large Scale ◽  
Clinical Manifestations ◽  
Research Network ◽  
Genetic Modifiers ◽  
Advisory Committees ◽  
Monogenic Diseases

Abstract Hemoglobinopathies, including sickle cell disease (SCD) and thalassemia syndromes, represent the commonest monogenic diseases in the world. Although their pathogenicity is well established, the diverse clinical manifestations and the varying degree of severity are less understood and are thought to be governed, in part, by genetic modifiers. Despite the identification and characterization of a few genetic modifiers by previous studies, these are as yet insufficient to guide treatment recommendations or stratify patients reliably. Larger, multi-ethnic studies are needed to identify and validate further disease modifiers that can be used for patient stratification and personalized treatment. There is a growing need for deeper insight with the availability of novel targeted therapies and potentially curative options like gene therapy in both SCD and thalassemia. The International Hemoglobinopathy Research Network (INHERENT) is a recently established network with the aim of investigating the role of genetic modifiers in hemoglobinopathies, through a large-scale, multi-ethnic genome-wide association study (GWAS). INHERENT brings together nine existing international or regional consortia in the field of hemoglobinopathies, namely ITHANET, RADeep, ARISE, SPARCO, SADaCC, REDAC, the HVP Global Globin Network, the International Health Repository, and the ClinGen Hemoglobinopathy VCEP. The activities of INHERENT are currently divided into five working groups, as follows: clinical, genotyping, data management and analysis, ethics, and knowledge translation. Participation in INHERENT is open for any group that can submit a minimum number of samples with their core phenotypic description. INHERENT membership is international and interdisciplinary and, currently, includes over 160 experts from 89 organizations, spanning 36 countries worldwide (Figure). INHERENT aims to recruit over 30,000 hemoglobinopathy patients, which is over one order of magnitude larger than any previous GWAS in the field. We demonstrate that the current membership of INHERENT has the potential to reach this sample size target. The large increase in the sample size and the diversity in the studied populations will enable novel discoveries and expand knowledge on hemoglobinopathy genetics, thus paving the way for advancing the science of personalized diagnosis and treatment. Figure 1 Figure 1. Disclosures Archer: Haemonetics: Current equity holder in publicly-traded company. Kuo: Bluebird Bio: Consultancy; Celgene: Consultancy; Alexion: Consultancy, Honoraria; Apellis: Consultancy; Bioverativ: Membership on an entity's Board of Directors or advisory committees; Novartis: Consultancy, Honoraria; Pfizer: Consultancy, Research Funding; Agios: Consultancy, Membership on an entity's Board of Directors or advisory committees. Maggio: Novartis: Membership on an entity's Board of Directors or advisory committees; Celgene Corp: Membership on an entity's Board of Directors or advisory committees; Bluebird Bio: Membership on an entity's Board of Directors or advisory committees. Mañú Pereira: Novartis: Research Funding; Agios Pharmaceuticals: Membership on an entity's Board of Directors or advisory committees, Research Funding.

EXPRESS: Toward Temporally Complex Collaboration in an Interorganizational Research Network

2021 ◽  
pp. 147612702110429
Author(s):  
Sirkka L Jarvenpaa ◽  
Liisa Valikangas
Keyword(s):  
Academic Research ◽  
Research Network ◽  
Interorganizational Networks ◽  
Agile Method ◽  
Joint Research ◽  
Research Results ◽  
Business Ecosystems ◽  
Narrative Time ◽  
Collective Benefit

Prior research suggests interorganizational collaboration faces temporal challenges but also opportunities yet is scarce on the role of time enabling – more often deterring - collaboration for collective benefit. Our contribution is highlighting how a large industry-academic research network developed temporally complex collaboration through varying temporal rules and relationships. The three network-developed collaborative repertoires, with their particular temporal rules and relationships, complemented the externally imposed calendar repertoire: (1) sprint repertoire, following a familiar agile method for joint research, (2) narrative time repertoire, enabling sharing research results across various events at the program level, and (3) “right” time repertoire that turned research results into action in emerging business ecosystems. With these collaborative repertoires, both the temporal diversities of home organizations and the asynchronies of the network activities were resolved for collective benefit. We contribute to the intersection of the literatures on interorganizational networks and temporality as befitting collaboration.

Prognostic value of dickkopf-1 and ß-catenin expression according to the antitumor immunity of CD8-positive tumor-infiltrating lymphocytes in biliary tract cancer.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e16172-e16172
Author(s):  
Seoree Kim ◽  
Yoon Ho Ko ◽  
Hye Sung Won ◽  
Ji Hyun Yang ◽  
Der Sheng Sun ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Cox Regression ◽  
Research Network ◽  
Antigen Retrieval ◽  
Tract Cancer ◽  
Tissue Sections ◽  
Dkk1 Expression

e16172 Background: Despite recent advancements in the understanding of the molecular biology of biliary tract cancer (BTC), target therapy and immunotherapy have demonstrated only limited efficacy, with cytotoxic systemic therapy still being the most effective treatment in BTC, except for surgery. Thus, this study aimed to analyze the role of DKK1 or β-catenin as a prognostic factor in BTC and determine the clinical association of ß-catenin and DKK1 with CD8+ tumor-infiltrating lymphocyte (TIL). Methods: We used data in The Cancer Genome Atlas (TCGA) Research Network and the clinicopathological data of 145 patients with BTC who had undergone primary radical resection between 2006 and 2016. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue sections, and whole tissue sections of representative tumor samples were used for antigen retrieval. Results: CD8+TIL expression was a significant predictor of favorable overall survival (OS) and recurrence-free survival (RFS) (median OS, 34.9months in TIL-high, 16.7months in TIL-low, P < 0.0001 respectively; median RFS, 27.1months in TIL-high, 10months in TIL-low, P < 0.0001 respectively). Positive ß-catenin expression and high DKK1 expression was also associated with a shorter OS (median OS, 23.95months in positive ß-catenin, 26.1months in negative ß-catenin, P = 0.1009 respectively; median OS, 19.4months in high DKK1, 31.65months in Low DKK1, P = 0.0093 respectively), but not RFS (p = 0.1466, at ß-catenin respectively; p = 0.2924, in DKK1 respectively). In the CD8+TIL-high BTC group, the tumor expression of β-catenin and DKK1 had a significant negative impact on either OS or RFS (p = 0.0146 and p = 0.0112, at ß-catenin respectively; p = 0.0950 and p = 0.3904, in DKK1 respectively). However, in the TIL-low BTC group, there were no differences in OS or RFS according to ß-catenin and DKK1 expression (p = 0.5108 and p = 0.8431, at ß-catenin respectively; p = 0.1127 and p = 0.1095, in DKK1 respectively). Cox regression multivariate analysis demonstrated that CD8+ TIL (hazard ratio [HR], 0.490; 95% confidence interval (CI), 0.303-0.791; p = 0.004) and β-catenin (HR, 1.652; 95% CI, 1.035-2.639; p = 0.036) retained significant association with OS after adjustment for all variables. Conclusions: Among patients with resected BTC, β-catenin and DKK1 protein levels are associated with poor clinical outcomes, whereas high CD8+ TIL levels are associated with good clinical outcomes. This confirms the differential clinical role of Wnt/β-catenin and DKK1 proteins according to TIL expression in BTC.

scholarly journals A spatial-temporal continuous dataset of the transpiration to evapotranspiration ratio in China from 1981–2015

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Zhongen Niu ◽  
Honglin He ◽  
Gaofeng Zhu ◽  
Xiaoli Ren ◽  
Li Zhang ◽  
...  
Keyword(s):  
Hydrological Cycle ◽  
Terrestrial Ecosystem ◽  
Research Network ◽  
Energy Budgets ◽  
Climate Data ◽  
Area Index ◽  
Large Variability ◽  
Ecosystem Research ◽  
Insight Into

Abstract The ratio of plant transpiration to total terrestrial evapotranspiration (T/ET) captures the role of vegetation in surface-atmosphere interactions. However, several studies have documented a large variability in T/ET. In this paper, we present a new T/ET dataset (also including transpiration, evapotranspiration data) for China from 1981 to 2015 with spatial and temporal resolutions of 0.05° and 8 days, respectively. The T/ET dataset is based on a model-data fusion method that integrates the Priestley-Taylor Jet Propulsion Laboratory (PT-JPL) model with multivariate observational datasets (transpiration and evapotranspiration). The dataset is driven by satellite-based leaf area index (LAI) data from GLASS and GLOBMAP, and climate data from the Chinese Ecosystem Research Network (CERN). Observational annual T/ET were used to validate the model, with R2 and RMSE values were 0.73 and 0.07 (12.41%), respectively. The dataset provides significant insight into T/ET and its changes over the Chinese terrestrial ecosystem and will be beneficial for understanding the hydrological cycle and energy budgets between the land and the atmosphere.

scholarly journals Kidney Cancer Research Network of Canada (KCRNC) consensus statement on the role of renal mass biopsy in the management of kidney cancer

2019 ◽  
Vol 13 (12) ◽  
Author(s):  
Ranjena Maloni ◽  
Luke T. Lavallée ◽  
Kristen McAlpine ◽  
Anil Kapoor ◽  
Frédéric Pouliot ◽  
...  
Keyword(s):  
Cancer Research ◽  
Kidney Cancer ◽  
Renal Mass ◽  
Consensus Statement ◽  
Research Network ◽  
Cancer Research Network ◽  
Renal Mass Biopsy

Benchmarking employment performance and labour market policies: the results of the Research project

1999 ◽  
Vol 5 (4) ◽  
pp. 542-562 ◽  
Author(s):  
Leonello Tronti
Keyword(s):  
Resource Management ◽  
Human Resource Management ◽  
Labour Market ◽  
Market Efficiency ◽  
Human Resource ◽  
Research Network ◽  
Methodological Issues ◽  
Labour Market Policies ◽  
Project Report

The paper presents the main findings of the project 'Benchmarking employment performance and labour market policies' conducted by the Research Network of the European Employment Observatory, under the direction of the author. After a preliminary overview of the analytical areas covered and the topics contained in the project report (para. 2), the paper considers the role of benchmarking in the implementation of the European Employment Strategy (para. 3). It goes on to present the main results and observations deriving from the whole project (para. 4), discussing some of the conceptual and methodological issues arising from the use of benchmarking techniques to foster convergence in labour market efficiency, employment performance, labour market policies and firms' human resource management. Some brief concluding remarks (para. 6) address the institutional implications that arise in the implementation of an effective benchmarking procedure aimed at meeting the requirements of the European Employment Strategy.

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