Restricted TRBC1 expression: a clonality marker for circulating Sézary cells

2021 ◽  
Author(s):  
Suzanne Tintle ◽  
Franklin Fuda ◽  
Weina Chen
Keyword(s):  
Sézary Cells

scholarly journals Expression of Vβ Gene Segments by Sezary Cells

1995 ◽  
Vol 105 (1) ◽  
pp. 56-61 ◽  
Author(s):  
Guy Gorochov ◽  
Hervé Bachelez ◽  
Jean Michel Cayuela ◽  
Eric Legac ◽  
Liliane Laroche ◽  
...  
Keyword(s):  
Sézary Cells

scholarly journals Blood and skin-derived Sezary cells: differences in proliferation-index, activation of PI3K/AKT/mTORC1 pathway and its prognostic relevance

Leukemia ◽  
2018 ◽  
Vol 33 (5) ◽  
pp. 1231-1242 ◽  
Author(s):  
Cristina Cristofoletti ◽  
Antonella Bresin ◽  
Mario Picozza ◽  
Maria Cristina Picchio ◽  
Francesca Monzo ◽  
...  
Keyword(s):  
Proliferation Index ◽  
Prognostic Relevance ◽  
Mtorc1 Pathway ◽  
Sézary Cells

scholarly journals CD158k/KIR3DL2 Is a New Phenotypic Marker of Sezary Cells: Relevance for the Diagnosis and Follow-Up of Sezary Syndrome

2004 ◽  
Vol 122 (3) ◽  
pp. 820-823 ◽  
Author(s):  
Ewa Poszepczynska-Guigné ◽  
Valérie Schiavon ◽  
Michel D'Incan ◽  
Hamid Echchakir ◽  
Philippe Musette ◽  
...  
Keyword(s):  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
Phenotypic Marker ◽  
Sézary Cells

scholarly journals Clonal rearrangement of the T cell receptor beta gene in the circulating lymphocytes of erythrodermic follicular mucinosis

Blood ◽  
1988 ◽  
Vol 71 (5) ◽  
pp. 1329-1333
Author(s):  
PE LeBoit ◽  
EA Abel ◽  
ML Cleary ◽  
RT Hoppe ◽  
ML Williams ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Receptor ◽  
Hair Follicles ◽  
Older Individuals ◽  
Abnormal Accumulation ◽  
Circulating Lymphocytes ◽  
Unusual Variant ◽  
T Cell Receptor Beta ◽  
Sézary Cells ◽  
Receptor Beta

Follicular mucinosis is a condition characterized by the abnormal accumulation of acidic mucopolysaccharides in hair follicles. It is classically described as occurring idiopathically in young persons and within the infiltrates of mycosis fungoides in older individuals. We report a 12-year-old girl who had erythrodermic follicular mucinosis, hypereosinophilia, circulating Sezary cells, and both immunophenotypic and genotypic evidence of T cell neoplasia. Erythrodermic follicular mucinosis may represent an unusual variant of the Sezary syndrome, which to date has not been described in children or adolescents.

scholarly journals The Role of Tumor Microenvironment in the Pathogenesis of Sézary Syndrome

2022 ◽  
Vol 23 (2) ◽  
pp. 936
Author(s):  
Denis Miyashiro ◽  
Bruno de Castro e Souza ◽  
Marina Passos Torrealba ◽  
Kelly Cristina Gomes Manfrere ◽  
Maria Notomi Sato ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Immune Dysregulation ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
Immunologic Response ◽  
T Cell Lymphomas ◽  
Sézary Cells ◽  
Peripheral Blood Involvement ◽  
Malignant T Cells

Sézary syndrome is an aggressive leukemic variant of cutaneous T-cell lymphomas, characterized by erythroderma, lymphadenopathy, and peripheral blood involvement by CD4+ malignant T-cells. The pathogenesis of Sézary syndrome is not fully understood. However, the course of the disease is strongly influenced by the tumor microenvironment, which is altered by a combination of cytokines, chemokines, and growth factors. The crosstalk between malignant and reactive cells affects the immunologic response against tumor cells causing immune dysregulation. This review focuses on the interaction of malignant Sézary cells and the tumor microenvironment.

scholarly journals Targeting Epigenetic Modifiers Can Reduce the Clonogenic Capacities of Sézary Cells

2021 ◽  
Vol 11 ◽  
Author(s):  
Alain Chebly ◽  
Martina Prochazkova-Carlotti ◽  
Yamina Idrissi ◽  
Laurence Bresson-Bepoldin ◽  
Sandrine Poglio ◽  
...  
Keyword(s):  
Dna Methyltransferase ◽  
Histone Deacetylase Inhibitors ◽  
Soft Agar ◽  
Tumor Formation ◽  
Human Telomerase Reverse Transcriptase ◽  
Hematological Disorders ◽  
Soft Agar Assay ◽  
Human Telomerase ◽  
Sézary Cells

Sézary syndrome (SS) is an aggressive leukemic variant of cutaneous T-cell lymphomas (CTCL) in which the human Telomerase Reverse Transcriptase (hTERT) gene is re-expressed. Current available treatments do not provide long-term response. We previously reported that Histone deacetylase inhibitors (HDACi, romidespin and vorinostat) and a DNA methyltransferase inhibitor (DNMTi, 5-azacytidine) can reduce hTERT expression without altering the methylation level of hTERT promoter. Romidepsin and vorinostat are approved for CTCL treatment, while 5-azacytidine is approved for the treatment of several hematological disorders, but not for CTCL. Here, using the soft agar assay, we analyzed the functional effect of the aforementioned epidrugs on the clonogenic capacities of Sézary cells. Our data revealed that, besides hTERT downregulation, epidrugs’ pressure reduced the proliferative and the tumor formation capacities in Sézary cells in vitro.

012 Immunological study on CD3 defective sezary cells

1996 ◽  
Vol 12 (2) ◽  
pp. 183
Author(s):  
S. Sano ◽  
Y. Matsui ◽  
A. Gotoh ◽  
S. Itami ◽  
K. Yoshikawa
Keyword(s):  
Immunological Study ◽  
Sézary Cells

scholarly journals Diminished CD3 Expression Is Useful for Detecting and Enumerating Sézary Cells

2000 ◽  
Vol 114 (3) ◽  
pp. 467-477 ◽  
Author(s):  
Jeffrey Edelman ◽  
Howard J. Meyerson
Keyword(s):  
Sézary Cells

Abstract 3912: The PI3K/mTOR dual inhibitor PF-04691502 shows antitumor activity in Sezary cells and in a xenograft mouse model

2019 ◽  
Author(s):  
Antonella Bresin ◽  
Cristina Cristofoletti ◽  
Francesca Monzo ◽  
Elisabetta Caprini ◽  
Mauro Helmer Citterich ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Mouse Model ◽  
Dual Inhibitor ◽  
Xenograft Mouse Model ◽  
Sézary Cells

scholarly journals Proliferation kinetics of Sezary cells

Blood ◽  
1981 ◽  
Vol 57 (6) ◽  
pp. 1049-1054 ◽  
Author(s):  
JD Schwarzmeier ◽  
E Paietta ◽  
T Radaszkiewicz ◽  
K Konrad ◽  
L Marosi
Keyword(s):  
Kinetic Studies ◽  
Large Mass ◽  
Lymphatic Tissue ◽  
Peripheral Cell ◽  
Proliferation Kinetics ◽  
Skin Cells ◽  
Considerable Portion ◽  
Double Label ◽  
Kinetics Of ◽  
Sézary Cells

Abstract The proliferation kinetics of neoplastic T cells arising in Sezary syndrome (Sezary cells) are still poorly understood. Kinetic studies with 3H-thymidine as a DNA precursor revealed a low incorporation rate of the nucleotide into Sezary cells obtained from the peripheral blood versus Sezary cells from the skin. Using the double-label autoradiography we determined the duration of single cell cycle phases of blood and cutaneous Sezary cells. The results indicate the almost complete lack of proliferative activity in the blood but a considerable portion of proliferatively active Sezary cells in skin infiltrates. The removal of a large mass of quiescent blood cells by leukapheresis did not affect the proliferative state of the residual peripheral cell population implying that the procedure did not induce the migration of proliferating skin cells towards the blood. Terminally, the disease underwent transition into immunoblastic lymphoma. At this time, the kinetic behavior of the peripheral immunoblasts showed great similarity to that of cutaneous Sezary cells. The findings point towards a common extravascular production site of Sezary cells and immunoblasts probably located in the lymphatic tissue.

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