scholarly journals Type of prior genotoxic insult determines the genomic characteristics of therapy‐related myeloid neoplasms

2021 ◽  
Author(s):  
Michael Ozga ◽  
James Blachly ◽  
Ann‐Kathrin Eisfeld ◽  
Nicole Grieselhuber ◽  
Karilyn Larkin ◽  
...  
Keyword(s):  
Myeloid Neoplasms ◽  
Genotoxic Insult

scholarly journals Complex landscape of alternative splicing in myeloid neoplasms

Leukemia ◽  
2020 ◽  
Author(s):  
Courtney E. Hershberger ◽  
Devlin C. Moyer ◽  
Vera Adema ◽  
Cassandra M. Kerr ◽  
Wencke Walter ◽  
...  
Keyword(s):  
Alternative Splicing ◽  
Myeloid Neoplasms ◽  
Complex Landscape

scholarly journals A case of hypereosinophilic syndrome with STAT5b N642H mutation

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Feihong Ding ◽  
Chaoping Wu ◽  
Yun Li ◽  
Sudipto Mukherjee ◽  
Subha Ghosh ◽  
...  
Keyword(s):  
Complete Blood Count ◽  
Hypereosinophilic Syndrome ◽  
Organ Damage ◽  
Myeloid Neoplasm ◽  
Acute Eosinophilic Pneumonia ◽  
Myeloid Neoplasms ◽  
Somatic Signal ◽  
Generation Sequencing

ABSTRACT Hypereosinophilia is defined as persistent eosinophilia (>1.5 × 109/L). Hypereosinophilic syndrome (HES) is a term used to describe a group of disorders characterized by sustained hypereosinophilia associated with end-organ damage. Based on underlying molecular mechanism of eosinophilia, there are different subtypes of HES. Diagnosis of HES subtype can be challenging, especially in the absence of overt lymphoid/myeloid neoplasms or discernable secondary causes. Long-term outpatient follow-up with periodic complete blood count and repeated bone marrow biopsy may be needed to monitor disease activity. Somatic signal transducer and activation transcription 5b (STAT5b) N642H mutation was recently found to be associated with myeloid neoplasms with eosinophilia. We report a case of HES who presented with pulmonary embolism and acute eosinophilic pneumonia, found to have recurrent STAT5b N642H mutation by next-generation sequencing, suggesting possible underlying myeloid neoplasm.

miR-23a mediates resistance to hypomethylating agents in myeloid neoplasms

2021 ◽  
Author(s):  
Marie-Christina Mayer ◽  
Johannes Lorenz Berg ◽  
Bianca Perfler ◽  
Stefan Hatzl ◽  
Sereina Annik Herzog ◽  
...  
Keyword(s):  
Hypomethylating Agents ◽  
Myeloid Neoplasms

scholarly journals Characteristics and outcomes of therapy-related myeloid neoplasms following autologous stem cell transplantation for multiple myeloma

2021 ◽  
Vol 11 (3) ◽  
Author(s):  
Kalyan Nadiminti ◽  
M. Hasib Sidiqi ◽  
Kapil Meleveedu ◽  
Hassan B. Alkhateeb ◽  
William J. Hogan ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Autologous Stem Cell Transplantation ◽  
Myeloid Neoplasms

scholarly journals EZH2 inactivation in RAS-driven myeloid neoplasms hyperactivates RAS-signaling and increases MEK inhibitor sensitivity

Leukemia ◽  
2021 ◽  
Author(s):  
Johannes Lorenz Berg ◽  
Bianca Perfler ◽  
Stefan Hatzl ◽  
Barbara Uhl ◽  
Andreas Reinisch ◽  
...  
Keyword(s):  
Mek Inhibitor ◽  
Ras Signaling ◽  
Myeloid Neoplasms
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