scholarly journals Gain‐of‐function mutations in PIEZO1 directly impair hepatic iron metabolism via the inhibition of the BMP/SMADs pathway

2019 ◽  
Vol 95 (2) ◽  
pp. 188-197 ◽  
Author(s):  
Immacolata Andolfo ◽  
Barbara Eleni Rosato ◽  
Francesco Manna ◽  
Gianluca De Rosa ◽  
Roberta Marra ◽  
...  
Keyword(s):  
Iron Metabolism ◽  
Hepatic Iron ◽  
Gain Of Function

scholarly journals S903 GAIN-OF-FUNCTION MUTATIONS IN PIEZO1 DIRECTLY IMPAIR HEPATIC IRON METABOLISM BY ALTERATIONS OF BMP/SMADS PATHWAY

HemaSphere ◽  
2019 ◽  
Vol 3 (S1) ◽  
pp. 407-408
Author(s):  
I. Andolfo ◽  
B.E. Rosato ◽  
F. Manna ◽  
G. De Rosa ◽  
R. Marra ◽  
...  
Keyword(s):  
Iron Metabolism ◽  
Hepatic Iron ◽  
Gain Of Function

scholarly journals Corrigendum: Strain- and time-dependent alterations in hepatic iron metabolism in a murine model of nonalcoholic steatohepatitis

2017 ◽  
Vol 35 (3) ◽  
pp. 192-193
Author(s):  
Steven A. Bloomer ◽  
Alicia K. Olivier ◽  
Ottar M. Bergmann ◽  
M. Meleah Mathahs ◽  
Kimberly A. Broadhurst ◽  
...  
Keyword(s):  
Iron Metabolism ◽  
Murine Model ◽  
Nonalcoholic Steatohepatitis ◽  
Time Dependent ◽  
Hepatic Iron

Strain- and time-dependent alterations in hepatic iron metabolism in a murine model of nonalcoholic steatohepatitis

2016 ◽  
Vol 34 (8) ◽  
pp. 628-639 ◽  
Author(s):  
Steven A. Bloomer ◽  
Alicia K. Olivier ◽  
Ottar M. Bergmann ◽  
M. Meleah Mathahs ◽  
Kimberly A. Broadhurst ◽  
...  
Keyword(s):  
Iron Metabolism ◽  
Murine Model ◽  
Nonalcoholic Steatohepatitis ◽  
Time Dependent ◽  
Hepatic Iron

Physiologic systemic iron metabolism in mice deficient for duodenal Hfe

Blood ◽  
2007 ◽  
Vol 109 (10) ◽  
pp. 4511-4517 ◽  
Author(s):  
Maja Vujic Spasic ◽  
Judit Kiss ◽  
Thomas Herrmann ◽  
Regina Kessler ◽  
Jens Stolte ◽  
...  
Keyword(s):  
Iron Metabolism ◽  
Iron Homeostasis ◽  
Iron Absorption ◽  
Binding Capacity ◽  
Hereditary Hemochromatosis ◽  
Direct Interaction ◽  
Hfe Gene ◽  
Hepatic Iron ◽  
Primary Role ◽  
Genes Encoding

Abstract Mutations in the Hfe gene result in hereditary hemochromatosis (HH), a disorder characterized by increased duodenal iron absorption and tissue iron overload. Identification of a direct interaction between Hfe and transferrin receptor 1 in duodenal cells led to the hypothesis that the lack of functional Hfe in the duodenum affects TfR1-mediated serosal uptake of iron and misprogramming of the iron absorptive cells. Contrasting this view, Hfe deficiency causes inappropriately low expression of the hepatic iron hormone hepcidin, which causes increased duodenal iron absorption. We specifically ablated Hfe expression in mouse enterocytes using Cre/LoxP technology. Mice with efficient deletion of Hfe in crypt- and villi-enterocytes maintain physiologic iron metabolism with wild-type unsaturated iron binding capacity, hepatic iron levels, and hepcidin mRNA expression. Furthermore, the expression of genes encoding the major intestinal iron transporters is unchanged in duodenal Hfe-deficient mice. Our data demonstrate that intestinal Hfe is dispensable for the physiologic control of systemic iron homeostasis under steady state conditions. These findings exclude a primary role for duodenal Hfe in the pathogenesis of HH and support the model according to which Hfe is required for appropriate expression of the “iron hormone” hepcidin which then controls intestinal iron absorption.

Su1966 Sitagliptin, a Dipeptidyl Peptidase-4 (DPP-4) Inhibitor, Can Be Effective Drug for Hepatic Iron Metabolism

2016 ◽  
Vol 150 (4) ◽  
pp. S601
Author(s):  
Shinya Fukunishi ◽  
Akira Asai ◽  
Yasuhiro Tsuda ◽  
Kazuhide Higuchi
Keyword(s):  
Iron Metabolism ◽  
Dipeptidyl Peptidase ◽  
Effective Drug ◽  
Hepatic Iron ◽  
Dipeptidyl Peptidase 4

scholarly journals S1629 ERFE-A260S ACCOUNTS FOR HEPATIC IRON METABOLISM IMPAIRMENT BY ACTING ON THE BMP-SMAD PATHWAY

HemaSphere ◽  
2019 ◽  
Vol 3 (S1) ◽  
pp. 753
Author(s):  
I. Andolfo ◽  
F. Manna ◽  
G. De Rosa ◽  
B.E. Rosato ◽  
R. Marra ◽  
...  
Keyword(s):  
Iron Metabolism ◽  
Hepatic Iron ◽  
Smad Pathway

Interstrain differences in the progression of nonalcoholic steatohepatitis to fibrosis in mice are associated with altered hepatic iron metabolism

2014 ◽  
Vol 25 (12) ◽  
pp. 1235-1242 ◽  
Author(s):  
Svitlana Shpyleva ◽  
Marta Pogribna ◽  
Christy Cozart ◽  
Matthew S. Bryant ◽  
Levan Muskhelishvili ◽  
...  
Keyword(s):  
Iron Metabolism ◽  
Nonalcoholic Steatohepatitis ◽  
Hepatic Iron ◽  
Interstrain Differences
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