scholarly journals Combination of bortezomib in the induction, conditioning and consolidation with autologous hematopoietic stem cell transplantation in patients with immunoglobulin light chain amyloidosis

2019 ◽  
Vol 94 (4) ◽  
Author(s):  
Xianghua Huang ◽  
Chengcheng Fu ◽  
Lijuan Chen ◽  
Wencui Chen ◽  
Guisheng Ren ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Light Chain ◽  
Immunoglobulin Light Chain ◽  
Hematopoietic Stem ◽  
Light Chain Amyloidosis ◽  
Immunoglobulin Light Chain Amyloidosis

Progressive Renal Light Chain Amyloidosis With the Absence of Detectable Free Monoclonal Light Chains After an Autologous Hematopoietic Stem Cell Transplant for Amyloid Light Chain Amyloidosis

2013 ◽  
Vol 137 (9) ◽  
pp. 1304-1308 ◽  
Author(s):  
Rachel M. Roth ◽  
Don Benson ◽  
Lee A. Hebert ◽  
Michael G. Bissell ◽  
Anjali A. Satoskar ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Light Chain ◽  
Hematopoietic Stem ◽  
Monoclonal Protein ◽  
Light Chain Amyloidosis ◽  
Amyloid Light Chain

Amyloid light chain amyloidosis involving the kidneys is not uncommon in patients with monoclonal gammopathy. The mainstay of treatment of amyloid light chain amyloidosis is autologous hematopoietic stem cell transplantation. Evidence that the autologous hematopoietic stem cell transplantation has been successful is the absence of free monoclonal light chains in serum and urine. Herein, we report 2 cases of progressive renal amyloid light chain amyloidosis after autologous hematopoietic stem cell transplantation, documented by kidney biopsy, despite the absence of monoclonal protein in the serum and urine. Kidney function declined progressively in both patients. During that time, numerous immunofixation and protein electrophoresis test results were negative for monoclonal protein, both in serum and urine, concealing the progression of the amyloidosis. We conclude that close monitoring of kidney function is warranted following autologous hematopoietic stem cell transplantation in patients with amyloid light chain amyloidosis, even with negative results from monoclonal protein testing. Unexplained, worsening renal function warrants a kidney biopsy to assess whether retreatment of the monoclonal gammopathy is indicated.

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