scholarly journals Germline transmission of LNKE208Q variant in a family with myeloproliferative neoplasms

2016 ◽  
Vol 91 (9) ◽  
pp. E356-E356 ◽  
Author(s):  
Giuseppe Gaetano Loscocco ◽  
Carmela Mannarelli ◽  
Annalisa Pacilli ◽  
Tiziana Fanelli ◽  
Giada Rotunno ◽  
...  
Keyword(s):  
Myeloproliferative Neoplasms ◽  
Germline Transmission

What Is the Role of JAK2V617F Mutation in Leukemic Transformation of Myeloproliferative Neoplasms?

2011 ◽  
Vol 17 (1) ◽  
pp. 12-16 ◽  
Author(s):  
Rodrigo Lopes da Silva ◽  
Patricia Ribeiro ◽  
Alexandra Lourenço ◽  
Susana Costa Santos ◽  
Margarida Santos ◽  
...  
Keyword(s):  
Myeloproliferative Neoplasms ◽  
Leukemic Transformation

Renal Infarction and Pulmonary Embolism in Patient with Myelodysplastic

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Mounia Bendari ◽  
Nouama Bouanani ◽  
Mohamed Amine Khalfaoui ◽  
Maryam Ahnach ◽  
Aziza Laaraj ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Myeloproliferative Neoplasms ◽  
Bone Biopsy ◽  
Bone Marrow Aspiration ◽  
Myeloproliferative Disorders ◽  
Acute Onset ◽  
International Prognostic Scoring System ◽  
Renal Infarction ◽  
The Right ◽  
Enhanced Computed Tomography

The myelodysplastic syndrome-myeloproliferative neoplasms (MDS/MPNs) are defined by a group of heterogeneous hematological malignancies resulting from stem cell−driven clonal growth of pathological hematopoietic progenitors and ineffective hematopoiesis, they are characterized concomitant myelodysplastic and myeloproliferative signs. Myelodysplastic/myeloproliferative disorders have been considered to have a higher risk of thrombus formation.We report a rare case about a 64 years old Moroccan woman, experienced renal infarction (RI) associated with pulmonary embolism as a complication of a myelodysplastic/myeloproliferative disorder.The patient complained of acute-onset severe left flank pain, a contrast-enhanced computed tomography (CT) of the chest and abdomen revealed RI by a large wedge-shaped defect in the right kidney with pulmonary embolism.Biological exam showed deep anemia, the bone marrow aspiration found myelodysplasia.the bone biopsy showed signs of myeloproliferatif disease. The karyotype was normal, BCR-ABL, JAK2, CALR mutations were absents, and MPL mutation was positive. The International Prognostic Scoring System (IPSS-R) was 0, and the patient was included to the low risk group.Anticoagulation therapy was initiated with heparin to treat RI and pulmonary embolism. Three months later, pulmonary embolism had resolved without the appearance of additional peripheral infarction.This case emphasizes the need to consider myelodysplastic/myeloproliferative disorders as a cause of infraction renal and pulmonary embolism.

Postępowanie u pacjentek z nowotworem mieloproliferacyjnym BCR-ABL ujemnym w ciąży

2019 ◽  
Vol 50 (3) ◽  
pp. 142-146
Author(s):  
Joanna Góra-Tybor
Keyword(s):  
Myeloproliferative Neoplasms

StreszczenieCiąża u pacjentki z nowotworem mieloproliferacyjnym (myeloproliferative neoplasms – MPN) BCR-ABL ujemnym wiąże się z szeregiem możliwych powikłań dotyczących zarówno matki, jak i płodu, takich jak: częstsze powikłania zakrzepowe i krwotoczne u matki, zwiększone ryzyko poronień, częstsze dysfunkcje łożyska i związane z nimi: opóźnienie wzrostu płodu, porody przedwczesne, późne utraty płodu. Opieka nad ciężarną z MPN wymaga ścisłej współpracy specjalistów hematologa i ginekologa oraz wdrożenia postępowania zgodnego z obowiązującymi standardami (właściwej profilaktyki przeciwzakrzepowej i ewentualnego leczenia cytoredukcyjnego). W artykule omówiono aktualne zalecenia dotyczące monitorowania i terapii w trakcie ciąży i okresie połogu u kobiety z MPN.

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