scholarly journals Thalidomide plus dexamethasone as a maintenance therapy after autologous hematopoietic stem cell transplantation improves progression-free survival in multiple myeloma

2012 ◽  
Vol 87 (10) ◽  
pp. 948-952 ◽  
Author(s):  
Angelo Maiolino ◽  
Vania T.M. Hungria ◽  
Marcia Garnica ◽  
Gislaine Oliveira-Duarte ◽  
Luciana C.O. Oliveira ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Maintenance Therapy ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Progression Free Survival ◽  
Hematopoietic Stem ◽  
Free Survival

scholarly journals Retrospective Analysis of 111 Cases of Multiple Myeloma Treated with Autologous Hematopoietic Stem Cell Transplantation

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 5833-5833
Author(s):  
Chengcheng Fu ◽  
Yun Xu ◽  
Juan Wang ◽  
Jin Zhou ◽  
Ling Ma ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Maintenance Therapy ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Autologous Transplantation ◽  
Hematopoietic Stem ◽  
Free Treatment

Abstract Though a large number of studies have confirmed that large dose chemotherapy combined with autologous transplantation can improve the OS and PFS in patients with multiple myeloma, the suitable time for transplantation is not yet conclusive. The impact of treatment depth on survival and the essentiality of maintenance therapy after autologous transplantation because of the maintenance-related side effects is also inconclusive. To evaluate the efficacy of autologous hematopoietic stem cell transplantation (ASCT) in the treatment of multiple myeloma (MM), the effects of transplantation timing, depth of treatment and maintenance therapy on survival in patients with multiple myeloma (MM). The data of 111 patients with multiple myeloma who received autologous hematopoietic stem cell transplantation (ASCT) from April 30, 2004 to June 30, 2015 were retrospectively analyzed. The median follow-up period was 31 (6-139) months. 109 of the 111 patients successfully underwent hematopoietic reconstruction,2 patients died of transplantation-related mortality. The overall response rates(ORR)rate increased from 82.9%(92/111)at pre-ASCT to 91.9%(102/111)at post-ASCT. The median progress free survival(PFS)was 50 months. The median overall survival(OS)was not reached. The median PFS and median OS in the sequential transplantation group were significantly better than those in the non sequential transplantation group (86 months vs33 months, P=0.001,not reached vs 43 months, P=0.000).The median PFS of patients achieving a nCR at pre-ASCT was longer than those not achieving a nCR group (62 months vs 34 months, P=0.023).OS showed any significance(not reached vs 47 months, P=0.094).The median PFS of patients achieving a nCR at post-ASCT was longer than those not achieving a nCR group (54 months vs 26 months, P=0.004).OS showed any significance(not reached vs 53 months, P=0.128).Regarding maintenance therapy:the group of patients achieving post-ASCT nCR:The median PFS of patients with maintenance therapy was longer than those without maintenance treatment(86 months vs 33 months, P=0.009).The median OS in maintenance therapy group was not reached,the median OS in the maintenance free treatment group was 47 months (P=0.004).The group of patients achieving less than nCR at post-ASCT:In the maintenance group, the median PFS was 26 months,the median PFS for maintenance free treatment group was 9 months (P=0.518).The median OS of patients with maintenance therapy was longer than those without maintenance treatment(53 months vs 28 months, P=0.011). Autologous transplantation after induction chemotherapy, with maintenance therapy is the preferred treatment for patients with MM.The depth of treatment has a great influence on the survival time of patients,Patients with nCR at any time during the therapy (pre-ASCT,post-ASCT) had longer OS.Maintenance therapy is associated with an extended OS, no matter whether a nCR is reached or not at post-ASCT. Disclosures No relevant conflicts of interest to declare.

Upfront Autologous Stem Cell Transplantation Overcome the poor Prognosis of Non-Germinal Center Subtype of diffuse Large B-Cell Lymphoma in Patients with Advanced Stage and Elevated Serum Lactate Dehydrogenase

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 3998-3998
Author(s):  
Yu Ri Kim ◽  
Soo-Jeong Kim ◽  
June-Won Cheong ◽  
Yundeok Kim ◽  
Ji Eun Jang ◽  
...  
Keyword(s):  
Stem Cell ◽  
High Risk ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Progression Free Survival ◽  
Molecular Classification ◽  
Hematopoietic Stem ◽  
Free Survival

Abstract Introduction: The role of frontline autologous hematopoietic stem cell transplantation (ASCT) high-risk diffuse large B-cell lymphoma (DLBCL) is still controversial. We investigated the role of upfront ASCT as consolidation for high-risk DLBCL treated with rituximab containing chemotherapy according to molecular classification. Methods: A total of 195 newly diagnosed DLBCL patients with advanced stage and elevated serum lactate dehydrogenase from three centers were retrospectively analyzed. All patients achieved more than partial response (PR) after completing conventional chemotherapy (cyclophosphamide, doxorubicin, vincristine, prednisone) with rituximab (R-CHOP). Molecular classification was performed according to Han's algorithm. Results: One hundred fifty (76.9%) patients achieved complete response (CR) and 45 (23.1%) patients PR after frontline R-CHOP chemotherapy. Among these patients, sixty six (33.8%) patients were received ASCT. The 2-year overall survival (OS) was 82.9% and the 2-year progression-free survival (PFS) was 72.1%. Seven (10.6%) patients were relapsed after ASCT while 29 (22.5%) patients were relapsed in non-transplant patients. Patients who treated with ASCT showed superior OS and PFS (P=0.036, P=0.005). According to final response, ASCT showed superior OS and PFS in PR patients (P = 0.024, P = 0.009) while it did not in CR patients. Among the 128 patients that underwent immunohistochemistry for molecular classification, 36 patients (28.1%) were classified to GCB type, 92 (72.9%) patients were non-GCB type. Twenty five (27.1%) non-GCB patients received ASCT showed significant survival benefit for OS and PFS (P=0.032, P=0.011) while GCB patients did not show the survival difference according to ASCT (Figure 1). In non-GCB DLBCL, ASCT was related with superior PFS both interim and final PR status (P = 0.006, P=0.028). There was no difference for OS and PFS between GCB and non-GCB type in ASCT patients while GCB patients showed superior OS and PFS in non-transplant patients (P = 0.048, P=0.009). Conclusions: ASCT as consolidation improved OS and PFS in high risk DLBCL patients following R-CHOP chemotherapy. Especially, it could overcome the poor prognosis of non-GCB type DLBCL. Upfront ASCT could be considered effective treatment options for non-GCB type high risk DLBCL. Figure 1. Overall survival and progression free survival according to autologous hematopoietic stem cell transplantation in non-GCB type DLBCL. Figure 1. Overall survival and progression free survival according to autologous hematopoietic stem cell transplantation in non-GCB type DLBCL. Figure 2 Figure 2. Disclosures No relevant conflicts of interest to declare.

scholarly journals Day 100 Peripheral Blood Absolute Lymphocyte/Monocyte Ratio and Survival in Classical Hodgkin's Lymphoma Postautologous Peripheral Blood Hematopoietic Stem Cell Transplantation

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Luis F. Porrata ◽  
David J. Inwards ◽  
Stephen M. Ansell ◽  
Ivana N. Micallef ◽  
Patrick B. Johnston ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Clinical Outcomes ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Peripheral Blood ◽  
Progression Free Survival ◽  
Hematopoietic Stem ◽  
Free Survival

Day 100 prognostic factors of postautologous peripheral blood hematopoietic stem cell transplantation (APBHSCT) to predict clinical outcome in classical Hodgkin lymphoma (cHL) patients have not been evaluated. Thus, we studied if the day 100 peripheral blood absolute lymphocyte/monocyte ratio (Day 100 ALC/AMC) affects clinical outcomes by landmark analysis from day 100 post-APBHSCT. Only cHL patients achieving a complete remission at day 100 post-APBHSCT were studied. From 2000 to 2010, 131 cHL consecutive patients qualified for the study. The median followup from day 100 was 4.1 years (range: 0.2–12.3 years). Patients with a Day 100 ALC/AMC ≥ 1.3 experienced superior overall survival (OS) and progression-free survival (PFS) compared with Day 100 ALC/AMC < 1.3 (from day 100: OS, median not reached versus 2.8 years; 5 years OS rates of 93% (95% CI, 83%–97%) versus 35% (95% CI, 19%–51%), resp., P<0.0001; from day 100: PFS, median not reached versus 1.2 years; 5 years PFS rates of 79% (95% CI, 69%–86%) versus 27% (95% CI, 14%–45%), resp., P<0.0001). Day ALC/AMC ratio was an independent predictor for OS and PFS. Thus, Day 100 ALC/AMC ratio is a simple biomarker that can help to assess clinical outcomes from day 100 post-APBHSCT in cHL patients.

scholarly journals Tandem Autologous Hematopoietic Stem Cell Transplantation in Very Young Patients with Multiple Myeloma

2020 ◽  
Vol 09 (04) ◽  
pp. 233-235
Author(s):  
Rahul Naithani ◽  
Nitin Dayal ◽  
Reeta Rai
Keyword(s):  
Multiple Myeloma ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Young Patients ◽  
Cell Transplant ◽  
Hematopoietic Stem ◽  
Platelet Recovery

Abstract Introduction Multiple myeloma (MM) in very young patients is uncommon, and no treatment guidelines exist for these patients. Patients and Methods We performed a retrospective analysis of five very young myeloma patients who underwent tandem autologous hematopoietic stem cell transplantation (HSCT). Results The median age was 37 years (range = 34–40 years). A median of two leukapheresis was performed (range = 1–4). The median number of hematopoietic stem cells collected was 5.4 × 106/kg (4.4–8.2 × 106/kg). During first transplant, four patients received melphalan of 200 mg/m2 and one patient received melphalan of 140 mg/m2 (due to renal failure) as conditioning regimen. Second transplant conditioning was melphalan of 200 mg/m2 for one patient and melphalan of 140 mg/m2 for remaining four patients. Two patients were in complete remission, and two were in very good partial remission and one patient progressed to active disease at the time of tandem autologous bone marrow transplant. All patients developed significant mucositis. Neutrophil and platelet recovery was longer in tandem autologous hematopoietic stem cell transplant. More viral infections were seen in tandem transplant. Day 30 and day 100 mortality was nil. Conclusion We present data on tandem autologous HSCTs in very young patients with MM in India. Responses continued to improve in this small series.

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