scholarly journals Systolic blood pressure peak during maximal exercise testing: A possible determinant of endothelial turnover in healthy subjects

2009 ◽  
Vol 84 (7) ◽  
pp. 449-450
Author(s):  
Michele M. Ciulla ◽  
Carola Gianni ◽  
Pietro Broglia ◽  
Silvia Lonati ◽  
Ilaria Silvestris ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Exercise Testing ◽  
Healthy Subjects ◽  
Maximal Exercise ◽  
Pressure Peak

Utility of Exercise Testing to Assess Aortic Recoarctation

1989 ◽  
Vol 1 (2) ◽  
pp. 163-170 ◽  
Author(s):  
Thomas M. Zellers ◽  
David J. Driscoll
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Exercise Testing ◽  
Maximal Exercise ◽  
Coarctation Of The Aorta ◽  
Coarctation Repair

Because it is not known how often and how uniformly exercise testing is used to “unmask” recurrent or persistent coarctation of the aorta, this study was designed to determine (a) the frequency with which exercise testing is used by the clinician to evaluate patients after coarctation repair, and (b) the hemodynamic measures obtained with exercise that are considered to be indicative of significant persistent or recurrent coarctation. Questionnaires were sent to 80 randomly selected pediatric cardiologists; 49 were returned completed. About half of the respondents performed exercise testing (ET) on all of their patients after coarctation repair and 75 % tested at least half. Those who supervised an exercise laboratory used ET for a significantly greater number of their patients. In descending order, rest arm-leg gradient (ALG), maximal exercise systolic blood pressure (MXBP), and postexercise ALG were considered the most important indicators of significant recoarctation. The majority of respondents made decisions based on data from the ET that were consistent with published guidelines.

Feedback effects of circulating norepinephrine on sympathetic outflow in healthy subjects

2005 ◽  
Vol 288 (2) ◽  
pp. H710-H715 ◽  
Author(s):  
Mikko P. Tulppo ◽  
Heikki V. Huikuri ◽  
Elli Tutungi ◽  
Derek S. Kimmerly ◽  
Adrian W. Gelb ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Sympathetic Activity ◽  
Healthy Subjects ◽  
Blood Pressure Variability ◽  
Feedback Inhibition ◽  
Adrenergic Blockade ◽  
Sympathetic Outflow ◽  
Systolic Blood Pressure Variability ◽  
Normalized Units

The amplitude of low-frequency (LF) oscillations of heart rate (HR) usually reflects the magnitude of sympathetic activity, but during some conditions, e.g., physical exercise, high sympathetic activity results in a paradoxical decrease of LF oscillations of HR. We tested the hypothesis that this phenomenon may result from a feedback inhibition of sympathetic outflow caused by circulating norepinephrine (NE). A physiological dose of NE (100 ng·kg−1·min−1) was infused into eight healthy subjects, and infusion was continued after α-adrenergic blockade [with phentolamine (Phe)]. Muscle sympathetic nervous activity (MSNA) from the peroneal nerve, LF (0.04–0.15 Hz) and high frequency (HF; 0.15–0.40 Hz) spectral components of HR variability, and systolic blood pressure variability were analyzed at baseline, during NE infusion, and during NE infusion after Phe administration. The NE infusion increased the mean blood pressure and decreased the average HR ( P < 0.01 for both). MSNA (10 ± 2 vs. 2 ± 1 bursts/min, P < 0.01), LF oscillations of HR (43 ± 13 vs. 35 ± 13 normalized units, P < 0.05), and systolic blood pressure (3.1 ± 2.3 vs. 2.0 ± 1.1 mmHg2, P < 0.05) decreased significantly during the NE infusion. During the NE infusion after PHE, average HR and mean blood pressure returned to baseline levels. However, MSNA (4 ± 2 bursts/min), LF power of HR (33 ± 9 normalized units), and systolic blood pressure variability (1.7 ± 1.1 mmHg2) remained significantly ( P < 0.05 for all) below baseline values. Baroreflex gain did not change significantly during the interventions. Elevated levels of circulating NE cause a feedback inhibition on sympathetic outflow in healthy subjects. These inhibitory effects do not seem to be mediated by pressor effects on the baroreflex loop but perhaps by a presynaptic autoregulatory feedback mechanism or some other mechanism that is not prevented by a nonselective α-adrenergic blockade.

scholarly journals Workload-indexed blood pressure response is superior to peak systolic blood pressure in predicting all-cause mortality

2019 ◽  
Vol 27 (9) ◽  
pp. 978-987 ◽  
Author(s):  
Kristofer Hedman ◽  
Nicholas Cauwenberghs ◽  
Jeffrey W Christle ◽  
Tatiana Kuznetsova ◽  
Francois Haddad ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Exercise Testing ◽  
Lower Risk ◽  
Metabolic Equivalents ◽  
Risk Of Mortality ◽  
Increased Risk ◽  
All Cause Mortality ◽  
Clinical Exercise Testing

Aims The association between peak systolic blood pressure (SBP) during exercise testing and outcome remains controversial, possibly due to the confounding effect of external workload (metabolic equivalents of task (METs)) on peak SBP as well as on survival. Indexing the increase in SBP to the increase in workload (SBP/MET-slope) could provide a more clinically relevant measure of the SBP response to exercise. We aimed to characterize the SBP/MET-slope in a large cohort referred for clinical exercise testing and to determine its relation to all-cause mortality. Methods and results Survival status for male Veterans who underwent a maximal treadmill exercise test between the years 1987 and 2007 were retrieved in 2018. We defined a subgroup of non-smoking 10-year survivors with fewer risk factors as a lower-risk reference group. Survival analyses for all-cause mortality were performed using Kaplan–Meier curves and Cox proportional hazard ratios (HRs (95% confidence interval)) adjusted for baseline age, test year, cardiovascular risk factors, medications and comorbidities. A total of 7542 subjects were followed over 18.4 (interquartile range 16.3) years. In lower-risk subjects ( n = 709), the median (95th percentile) of the SBP/MET-slope was 4.9 (10.0) mmHg/MET. Lower peak SBP (<210 mmHg) and higher SBP/MET-slope (>10 mmHg/MET) were both associated with 20% higher mortality (adjusted HRs 1.20 (1.08–1.32) and 1.20 (1.10–1.31), respectively). In subjects with high fitness, a SBP/MET-slope > 6.2 mmHg/MET was associated with a 27% higher risk of mortality (adjusted HR 1.27 (1.12–1.45)). Conclusion In contrast to peak SBP, having a higher SBP/MET-slope was associated with increased risk of mortality. This simple, novel metric can be considered in clinical exercise testing reports.

scholarly journals Relation of body mass index (BMI) with cardiovascular response to head up tilt in healthy subjects

2020 ◽  
Vol 15 (1) ◽  
pp. 6-10
Author(s):  
Sadia Afrin Rimi ◽  
Shamima Sultana ◽  
Iffat Rezwana ◽  
Sultana Ferdousi
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Systolic Blood Pressure ◽  
Healthy Subjects ◽  
Cardiovascular Response ◽  
Tilt Test ◽  
Tilt Table ◽  
Chi Square ◽  
Female Head ◽  
Head Up Tilt

Background: Tilt table test is used for the last few decades to detect cause in unexplained syncope. The response to tilting may vary physiologically with obesity. Objective: To assess the relationship of BMI to cardiovascular response to tilting. Methods: This experimental study was conducted from March 2019 to Feb 2020 on 90 healthy subjects with different BMI. Fifty one subjects of both gender with BMI 18.5-24.9 kg/m2 were included in the non-obese group and 39 subjects of both gender with BMI of 25-29.9 kg/m2 were included in overweight group and they were further subdivided into male and female. Head up tilting was done for 10 minutes at 600 by using a motorized tilt table. Systolic blood pressure (SBP), diastolic blood pressure (DBP) were recorded by an automatic sphygmomanometer. Heart rate (HR) and peripheral capillary oxygen saturation (SpO2) were measured by a pulse oximeter. For statistical analysis, Independent sample ‘t’ test, Pearson’s correlation test and Chi square tests were applied. Results: Significantly smaller rise of heart rate was observed in overweight males and greater fall of systolic blood pressure was observed in overweight females. Conclusion: This study concluded that over weight is associated with reduced orthostatic tolerance to head up tilt test in both genders. J Bangladesh Soc Physiol. 2020, June; 15(1): 6-10

Assessment of Coronary Artery Disease in Hemodialysis Patients with Delayed Systolic Blood Pressure Response after Exercise Testing

2005 ◽  
Vol 23 (6) ◽  
pp. 466-472 ◽  
Author(s):  
Masayoshi Fukui ◽  
Yasukiyo Mori ◽  
Kazuya Takehana ◽  
Hiroya Masaki ◽  
Masayuki Motohiro ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Systolic Blood Pressure ◽  
Exercise Testing ◽  
Blood Pressure Response ◽  
Hemodialysis Patients ◽  
Pressure Response ◽  
Artery Disease

Lack of association between systolic blood pressure and blood viscosity in normotensive healthy subjects

2012 ◽  
Vol 51 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Concetta Irace ◽  
Claudio Carallo ◽  
Faustina Scavelli ◽  
Antonio Loprete ◽  
Valentina Merante ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Blood Viscosity ◽  
Healthy Subjects

scholarly journals Relation of serum uric acid to an exaggerated systolic blood pressure response to exercise testing in men with normotension

2018 ◽  
Vol 20 (3) ◽  
pp. 551-556 ◽  
Author(s):  
Sae Young Jae ◽  
Kanokwan Bunsawat ◽  
Yoon-Ho Choi ◽  
Yeon Soo Kim ◽  
Rhian M. Touyz ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Systolic Blood Pressure ◽  
Serum Uric Acid ◽  
Exercise Testing ◽  
Blood Pressure Response ◽  
Pressure Response ◽  
Response To Exercise

scholarly journals Heart Rate Recovery and Systolic Blood Pressure Recovery After Maximal Exercise in Prevalent Users of Stimulant Medications

2016 ◽  
Vol 36 (3) ◽  
pp. 295-297 ◽  
Author(s):  
Arthur N. Westover ◽  
Paul A. Nakonezny ◽  
Carolyn E. Barlow ◽  
Bryon Adinoff ◽  
E. Sherwood Brown ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Systolic Blood Pressure ◽  
Maximal Exercise ◽  
Heart Rate Recovery ◽  
Pressure Recovery ◽  
Stimulant Medications

The physiological response of ankle systolic blood pressure and ankle to brachial index after maximal exercise in athletes is dependent on age

2005 ◽  
Vol 96 (5) ◽  
pp. 505-510 ◽  
Author(s):  
Alexis Le Faucheur ◽  
Bénédicte Noury Desvaux ◽  
Philippe Bouyé ◽  
Vincent Jaquinandi ◽  
Jean Louis Saumet ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Physiological Response ◽  
Maximal Exercise
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