Effect of eradication ofHelicobacter pylori on platelet recovery in patients with chronic idiopathic thrombocytopenic purpura: A controlled trial

2008 ◽  
Vol 83 (5) ◽  
pp. 376-381 ◽  
Author(s):  
Nematollah Rostami ◽  
Maryam Keshtkar-Jahromi ◽  
Mohammad Rahnavardi ◽  
Marzieh Keshtkar-Jahromi ◽  
Fatemeh Soghra Esfahani
Keyword(s):  
Idiopathic Thrombocytopenic Purpura ◽  
Controlled Trial ◽  
Chronic Idiopathic Thrombocytopenic Purpura ◽  
Thrombocytopenic Purpura ◽  
Platelet Recovery

Helicobacter pylorieradication can induce platelet recovery in chronic idiopathic thrombocytopenic purpura

Platelets ◽  
2006 ◽  
Vol 17 (4) ◽  
pp. 227-230 ◽  
Author(s):  
Nada Suvajdžić ◽  
Boris Stanković ◽  
Vera Artiko ◽  
Tanja Cvejić ◽  
Vladislava Bulat ◽  
...  
Keyword(s):  
Idiopathic Thrombocytopenic Purpura ◽  
Chronic Idiopathic Thrombocytopenic Purpura ◽  
Thrombocytopenic Purpura ◽  
Platelet Recovery

Acute kidney injury and nephrotic syndrome associated with eltrombopag therapy in chronic idiopathic thrombocytopenic purpura

2021 ◽  
Vol 14 (4) ◽  
pp. e241462
Author(s):  
Suchi Anindita Ghosh ◽  
Jean Patrick ◽  
Kyaw Zin Maw
Keyword(s):  
Acute Kidney Injury ◽  
Renal Failure ◽  
Nephrotic Syndrome ◽  
Idiopathic Thrombocytopenic Purpura ◽  
Kidney Injury ◽  
High Dose ◽  
Chronic Idiopathic Thrombocytopenic Purpura ◽  
Thrombocytopenic Purpura ◽  
Antibody Screen ◽  
Auto Antibody

A 77-year-old man was admitted with severe acute kidney injury and nephrotic syndrome. He was started on eltrombopag for chronic idiopathic thrombocytopenic purpura 6 weeks earlier. An ultrasound of the kidneys was normal and an auto-antibody screen was negative. The use of the Naranjo adverse drug reaction probability scale indicated a probable relationship (score of 5) between the patient’s development of acute renal failure and eltrombopag therapy. Literature review identified only one other case of nephrotic syndrome and acute kidney injury associated with eltrombopag therapy in which a kidney biopsy revealed focal segmental glomerulosclerosis. Due to the challenges faced during the prevailing SARS-CoV-2 pandemic and persistent low platelet counts a renal biopsy was not undertaken. On stopping eltrombopag, the patients renal function stabilised and he successfully went into remission following treatment with high dose corticosteroids and diuretics. This report of a serious case of reversible renal failure and nephrotic syndrome after treatment with eltrombopag may serve to inform clinicians about the possible severe renal adverse effects of eltrombopag before its commencement for future use.

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