scholarly journals Insufficient outcomes with imatinib mesylate: Case report of Ph-positive acute myeloid leukemia evolving from myelodysplastic syndrome

2007 ◽  
Vol 82 (6) ◽  
pp. 501-502 ◽  
Author(s):  
Atsushi Isoda ◽  
Hirotaka Nakahashi ◽  
Takumi Hoshino ◽  
Takeki Mitsui ◽  
Yasushi Yoshida
Keyword(s):  
Acute Myeloid Leukemia ◽  
Case Report ◽  
Myelodysplastic Syndrome ◽  
Imatinib Mesylate ◽  
Myeloid Leukemia ◽  
Acute Myeloid

scholarly journals Myelodysplastic syndrome with myelofibrosis in a 12-year-old patient – A case report

2018 ◽  
Vol 26 (1) ◽  
pp. 95-103
Author(s):  
Andreea Oltean ◽  
Mihaela Ioana Chincesan ◽  
Oana Marginean ◽  
Emoke Horvath
Keyword(s):  
Bone Marrow ◽  
Acute Myeloid Leukemia ◽  
Case Report ◽  
Myelodysplastic Syndrome ◽  
Myeloid Leukemia ◽  
Cell Lineage ◽  
Response To Treatment ◽  
Hematopoietic Stem ◽  
Pediatric Clinic ◽  
Acute Myeloid

Abstract Myelodysplastic syndromes are a heterogeneous group of clonal disorders characterized by peripheral blood cytopenia and normal or hypercellular bone marrow with dysplasia in more than one blood cell lineage, unfavorable prognosis, and lack of response to treatment. We present the case of a 12-year-old male patient who was referred to the Hematology and Oncology Department of Pediatric Clinic I Târgu- Mures in May 2016, with splenomegaly and pancytopenia. The osteomedullary biopsy revealed myelofibrosis, discrete dysplasia of the myeloid series and megakaryocytes, blasts CD34+ approximately 10%, which led to the diagnosis of myelodysplastic syndrome with myelofibrosis. The myeloid precursors indicated a high risk of transformation into acute myeloid leukemia, so chemotherapy associated with corticosteroids was started, leading to slight improvements. Although myelodysplastic syndrome associated with myelofibrosis is rare at this age, despite the treatment and favorable progression in the case presented, in the absence of hematopoietic stem cell transplantation the prognosis remains unfavorable.

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