scholarly journals Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein receptor 1B

2007 ◽  
Vol 82 (3) ◽  
pp. 179-184 ◽  
Author(s):  
Vikki G. Nolan ◽  
Qianli Ma ◽  
Herbert T. Cohen ◽  
Adeboye Adewoye ◽  
Anne C. Rybicki ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Bone Morphogenetic Protein ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Bone Morphogenetic Protein Receptor ◽  
Protein Receptor ◽  
Morphogenetic Protein

scholarly journals Rapid decline in estimated glomerular filtration rate in sickle cell anemia: results of a multicenter pooled analysis

Haematologica ◽  
2020 ◽  
pp. 0-0
Author(s):  
Kenneth I. Ataga ◽  
Qingning Zhou ◽  
Vimal K. Derebail ◽  
Santosh L. Saraf ◽  
Jane S. Hankins ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Pooled Analysis ◽  
Rapid Decline

Not available.

scholarly journals Microalbuminuria risks and glomerular filtration in children with sickle cell anaemia in Nigeria

2019 ◽  
Vol 45 (1) ◽  
Author(s):  
I. E. Ocheke ◽  
S. Mohamed ◽  
E. S. Okpe ◽  
F. Bode-Thomas ◽  
M. I. McCullouch
Keyword(s):  
Risk Factors ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Sickle Cell ◽  
Filtration Rate ◽  
Sickle Cell Anaemia ◽  
Estimated Glomerular Filtration Rate ◽  
Kidney Damage ◽  
Strong Positive Correlation ◽  
Cross Sectional

Abstract Introduction Evidence of kidney damage is observed in children with sickle cell anaemia (SCA) and this continues through adulthood with progression to severe functional impairment in some. One of the earliest features of kidney damage associated with SCA is microalbuminuria. Our objective was to determine the risk factors of microalbuminuria in these children and its relationship with estimated glomerular filtration rate. Methods This was a cross-sectional and comparative study involving three hundred and twenty three children with SCA in steady state and equal numbers of apparently healthy age and sex matched haemoglobin AA (HbAA) control, aged 6 months to 18 years. They were consecutively recruited over a 6 month period. Result Microalbuminuria was present in 26% of the study subjects compared with 1.85% of control P = 0.001). Anaemia and high estimated glomerular filtration rate (eGFR) showed strong positive correlation with microalbuminuria (OR = 3.19, CI 0.953–1.116, p = 0.003 and OR = 1.7, CI 1.042–1.066, p = 0.001 respectively). Similarly, eGFR was higher in subjects with SCA than in controls and as well as in those with microalbuminuria compared with those who do not (p = < 0.01). Conclusions The two most important risk factors for microalbuminuria were anaemia and high eGFR. Age category was associated more with microalbuminuria than just age as a variable. Glomerular filtration rate was higher in children with microalbuminuria than those who do not and it was also higher in children with SCA than in control.

Elevated Glomerular Filtration Rate (GFR) in Young Patients with Sickle Cell Anemia.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 3745-3745
Author(s):  
Sherri A. Zimmerman ◽  
Jacqueline S. Davis ◽  
Nicole A. Mortier ◽  
Russell E. Ware
Keyword(s):  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Young Children ◽  
Glomerular Filtration ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Filtration Rate ◽  
Plasma Clearance ◽  
Glomerular Hyperfiltration ◽  
Schwartz Equation

Abstract Nephropathy is a well-recognized complication of sickle cell anemia (SCA) that is associated with considerable morbidity and mortality. Sickle nephropathy begins early in life, with glomerular damage characterized by hyperfiltration and glomerulomegaly, as well as tubular damage characterized by hyposthenuria. School-aged children can develop proteinuria and one-third of patients will eventually develop chronic renal failure as adults. Among the earliest markers of sickle nephropathy is glomerular hyperfiltration, typically measured as an elevated glomerular filtration rate (GFR). To date, however, no formal measurements of GFR have been published in young children with SCA, and its feasibility and interpretation in this age group have not been demonstrated. As part of a prospective, single-institution, IRB-approved open-label protocol using hydroxyurea in toddlers with SCA, the pre-treatment GFR was measured using plasma clearance of 99-Tc DTPA. The goal of this procedure was to determine the onset of hyperfiltration among young children with SCA, to identify risk factors associated with its onset, and to investigate the potential benefit of hydroxyurea in improving or preserving renal function. After intravenous injection of the DTPA radiotracer, 3–5 mL aliquots of venous blood were removed at 1 and 3 hours post-injection and analyzed for plasma radioactivity. Because DTPA is filtered at the glomerulus without substantial metabolism, secretion, or reabsorption, the plasma clearance allows an accurate and precise GFR measurement. The GFR was also estimated using the Schwartz equation, where GFR = height (cm) x k/serum creatinine, with k=0.55 for children between ages 1 and 12 years. A total of 13 children with HbSS (3 females, 10 males) were enrolled in this study, none of whom had laboratory evidence of renal disease at the time of evaluation. One child could not complete the DTPA study due to inadequate venous access. For the remaining 12 children, baseline GFR measurements were performed at age 3.0 ± 0.8 years (range 1.7 to 4.4 years) without complications. The average GFR measurement (mean ± SD) by DTPA clearance was 140.3 ± 20 mL/min/1.73m2, median 133 mL/min/1.73m2, range 117.9 to 172.7 mL/min/1.73m2 (normal 100 ± 20 mL/min/1.73m2). The baseline DTPA GFR measurement was elevated above 150 mL/min/1.73m2 in 5 of the 12 children, including 4 of 7 over age 3 years, although there was no signfiicant correlation between GFR and age or fetal hemoglobin. GFR estimates by the Schwartz equation were modestly correlated with the DTPA GFR measurements (R2 = 0.32, p = 0.055) but were typically slightly higher than the corresponding DTPA measurements. Three children who completed 24 months of hydroxyurea therapy had post-treatment DTPA clearance studies that revealed stable GFR measurements (average increase = 5.6 mL/min/1.73m2). These results illustrate that GFR measurement by DTPA clearance can be performed without difficulty in young children with SCA, requiring only peripheral intravenous access. Glomerular hyperfiltration as a manifestation of renal damage begins early in life for children with SCA, with elevated GFR values observed in the toddler age range. The Schwartz equation provides an estimate of GFR but probably cannot be used in lieu of the DTPA clearance study. Treatment with hydroxyurea may preserve renal function by abrogating further GFR hyperfiltration.

scholarly journals High bias and low precision for estimated versus measured glomerular filtration rate in pediatric sickle cell anemia

Haematologica ◽  
2020 ◽  
Vol 106 (1) ◽  
pp. 295-298
Author(s):  
Jeffrey D. Lebensburger ◽  
Jeffrey Gossett ◽  
Rima Zahr ◽  
Winfred C. Wang ◽  
Kenneth I. Ataga ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Filtration Rate ◽  
Measured Glomerular Filtration Rate ◽  
High Bias

scholarly journals Sex differences in the trajectory of glomerular filtration rate in pediatric and murine sickle cell anemia

2020 ◽  
Vol 4 (2) ◽  
pp. 263-265
Author(s):  
Malgorzata Kasztan ◽  
Inmaculada Aban ◽  
Suraj P. Hande ◽  
David M. Pollock ◽  
Jeffrey D. Lebensburger
Keyword(s):  
Sex Differences ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Filtration Rate

Important clinical and laboratory correlates of glomerular filtration rate in sickle cell anemia

2015 ◽  
Vol 18 (5) ◽  
pp. 633 ◽  
Author(s):  
AJ Madu ◽  
A Ubesie ◽  
S Ocheni ◽  
J Chinawa ◽  
KA Madu ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Filtration Rate
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