scholarly journals Cough mixture abuse in pregnancy, folate deficiency, and neural tube defects?

2005 ◽  
Vol 78 (2) ◽  
pp. 163-163 ◽  
Author(s):  
S.K. Tsang ◽  
W.Y. Au
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Folate Deficiency ◽  
Cough Mixture ◽  
In Pregnancy

Vitamin B9 (folate) in pregnancy and breastfeeding

2015 ◽  
Author(s):  
Sir Peter Gluckman ◽  
Mark Hanson ◽  
Chong Yap Seng ◽  
Anne Bardsley
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Folate Deficiency ◽  
Methylation Of Dna ◽  
Dna And Rna ◽  
Vitamin B9 ◽  
Dna And Rna Synthesis ◽  
One Carbon Metabolism ◽  
Inhibition Of Dna Synthesis ◽  
In Pregnancy

Folate is a coenzyme in multiple biochemical pathways involving one-carbon metabolism, including amino acid metabolism, DNA and RNA synthesis, homocysteine metabolism, and methylation of DNA. The most overt consequence of folate deficiency is megaloblastic anaemia caused by the inhibition of DNA synthesis in red blood cell production. Folate deficiency may also influence the ability to maintain DNA methylation patterns in replicating cells, resulting in lasting phenotypic changes. Embryogenesis and fetal growth require higher levels of folate, which must be supplied maternally during pregnancy. A link between low maternal folate levels and the occurrence of neural tube defects has long been recognized. Other effects in pregnancy include increased risks of pre-eclampsia and placental vascular disorders. The general recommendation is for supplementation prior to conception and throughout pregnancy with 400 #amp;#x03BC;g of folic acid in tablet form, in addition to dietary sources, which can reduce the risk of neural tube defects.

scholarly journals Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function

2008 ◽  
Vol 17 (23) ◽  
pp. 3675-3685 ◽  
Author(s):  
K. A. Burren ◽  
D. Savery ◽  
V. Massa ◽  
R. M. Kok ◽  
J. M. Scott ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Folate Deficiency ◽  
Gene Environment

scholarly journals Maternal herpes labialis in pregnancy and neural tube defects

2007 ◽  
Vol 48 (8) ◽  
pp. 674-676 ◽  
Author(s):  
Bente Nørgård ◽  
Mette Nørgaard ◽  
Andrew E Czeizel ◽  
Erzsébet Puhó ◽  
Henrik T Sørensen
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Herpes Labialis ◽  
In Pregnancy

scholarly journals Community acceptability of dolutegravir-based HIV treatment in women: a qualitative study in South Africa and Uganda

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yussif Alhassan ◽  
Adelline Twimukye ◽  
Thoko Malaba ◽  
Catherine Orrell ◽  
Landon Myer ◽  
...  
Keyword(s):  
South Africa ◽  
Focus Group ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Urban Poor ◽  
Hiv Treatment ◽  
Childbearing Age ◽  
Community Awareness ◽  
Depth Interviews ◽  
In Pregnancy

Abstract Background Despite concerns about dolutegravir use in pregnancy, most low- and middle-income countries are accelerating the introduction of dolutegravir-based regimens into national antiretroviral treatment programmes. Questions remain about the acceptability of dolutegravir use in women due to the potential risks in pregnancy. This study from South Africa and Uganda explored community values, preferences and attitudes towards the use of dolutegravir-based regimens in women. Methods This study employed a qualitative design involving in-depth interviews and focus group discussion conducted between August 2018 to March 2019. The study was conducted in the months following an announcement of a potential risk for neural tube defects with dolutegravir use among women during conception and the first trimester. Participants included HIV positive pregnant and lactating women and their partners. They were selected purposively from urban poor communities in South Africa and Uganda. Data was analysed thematically in NVivo. Results Forty-four in-depth interviews and 15 focus group discussions were conducted. Most participants had positive views of dolutegravir-based regimens and perceived it to be more desirable compared with efavirenz-containing regimens. There was widespread concern about use of dolutegravir during pregnancy and among women of childbearing age due to publicity around the possible association with neural tube defects. Acceptability was gendered, with nearly all male participants preferring their female spouses of childbearing potential not to use dolutegravir, while most women not planning pregnancy wanted access to contraception alongside dolutegravir. Community awareness and knowledge of dolutegravir was low and characterised by negative information. Women were concerned about HIV-related stigma and wanted the privacy features of dolutegravir to be strengthened with modification of the pill appearance and disguised packaging. Conclusions Dolutegravir-based regimens were found to be generally acceptable for use in women except during pregnancy. Interest in a dolutegravir-based regimen was linked with its perceived potential to enhance health, privacy and reduce stigma while concerns about neural tube defects were the main potential barrier to dolutegravir uptake in women. In order to optimise the community acceptability and uptake of acceptability-based regimen among women it is critical to strengthen community awareness and understanding of dolutegravir treatment, improve contraception services alongside the introduction of dolutegravir, and engage with male partners.

scholarly journals Folate Deficiency and Prevalence of Neural Tube Defects [NTDs] in Georgia

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Robizon Tsiklauri ◽  
P. Imnadze ◽  
L. Jijeishvili ◽  
J. Saganelidze
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Folate Deficiency

scholarly journals Periconceptional Folate Deficiency and Implications in Neural Tube Defects

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
J. Safi ◽  
L. Joyeux ◽  
G. E. Chalouhi
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Best Practice ◽  
Dietary Habits ◽  
Fetal Surgery ◽  
Folate Deficiency ◽  
Folic Acid Supplementation ◽  
Reproductive Age ◽  
Nutritional Deficiencies ◽  
Preventive Public Health

Nutritional deficiencies are preventable etiological and epigenetic factors causing congenital abnormalities, first cause of infant mortality. Folate deficiency has a well-established teratogenic effect, leading to an increasing risk of neural tube defects. This paper highlights the most recent medical literature about folate deficiency, be it maternal or paternal. It then focuses on associated deficiencies as nutritional deficiencies are multiple and interrelated. Observational and interventional studies have all been consistent with a 50–70% protective effect of adequate women consumption of folates on neural tube defects. Since strategies to modify women’s dietary habits and vitamin use have achieved little progress, scientific as well as political effort is mandatory in order to implement global preventive public health strategies aimed at improving the alimentation of women in reproductive age, especially folic acid supplementation. Even with the recent breakthrough of fetal surgery for myelomeningocele, the emphasis should still be on prevention as the best practice rather than treatment of neural tube defects.

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