Potential role of the ventilation and perfusion (V/Q) lung scan in the diagnosis of acute chest syndrome in adults with sickle cell disease

2004 ◽  
Vol 77 (4) ◽  
pp. 407-409 ◽  
Author(s):  
Navleen Kaur ◽  
Bharat Motwani ◽  
Devaki Sivasubramaniam ◽  
Lori Feldman ◽  
Sandra Allen ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Potential Role ◽  
Acute Chest Syndrome ◽  
Cell Disease ◽  
Lung Scan ◽  
Ventilation And Perfusion

scholarly journals Sickle cell patient with an acute chest syndrome and a negative chest X-ray: Potential role of the ventilation and perfusion (V/Q) lung scan

2003 ◽  
Vol 74 (3) ◽  
pp. 214-215 ◽  
Author(s):  
Lawrence Feldman ◽  
Robert Gross ◽  
Jack Garon ◽  
Anitha Nallari ◽  
Navleen Kaur ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Potential Role ◽  
Acute Chest Syndrome ◽  
X Ray ◽  
Lung Scan ◽  
Chest X Ray ◽  
Ventilation And Perfusion

scholarly journals Plastic Bronchitis and the Role of Bronchoscopy in the Acute Chest Syndrome of Sickle Cell Disease

CHEST Journal ◽  
2001 ◽  
Vol 120 (2) ◽  
pp. 608-613 ◽  
Author(s):  
Chuanpit Moser ◽  
Eliezer Nussbaum ◽  
Dan M. Cooper
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Acute Chest Syndrome ◽  
Plastic Bronchitis ◽  
Cell Disease

Role of Chlamydia pneumoniae in acute chest syndrome of sickle cell disease

1991 ◽  
Vol 118 (1) ◽  
pp. 30-33 ◽  
Author(s):  
Scott T. Miller ◽  
Margaret R. Hammerschlag ◽  
Keith Chirgwin ◽  
Sreedhar P. Rao ◽  
Patricia Roblin ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Chlamydia Pneumoniae ◽  
Acute Chest Syndrome ◽  
Cell Disease

Acute chest syndrome: the role of erythro-exchange in patients with sickle cell disease in Sicily

2003 ◽  
Vol 29 (1) ◽  
pp. 39-44 ◽  
Author(s):  
Turiddu Lombardo ◽  
Rosamaria Rosso ◽  
Alfio La Ferla ◽  
Maria Gabriella Ferro ◽  
Benedetta Ximenes ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Acute Chest Syndrome ◽  
Cell Disease

scholarly journals Sickle cell disease: when and how to transfuse

Hematology ◽  
2016 ◽  
Vol 2016 (1) ◽  
pp. 625-631 ◽  
Author(s):  
Jo Howard
Keyword(s):  
Sickle Cell Disease ◽  
Observational Data ◽  
Sickle Cell ◽  
Randomized Trials ◽  
Acute Chest Syndrome ◽  
Cell Disease ◽  
Chronic Complications ◽  
Advantages And Disadvantages

Abstract Blood transfusion remains an important therapeutic intervention in patients with sickle cell disease (SCD), aiming to both increase the oxygen carrying capacity of blood and to reduce the complications of vaso-occlusion. Simple, manual exchange and automated exchange can be effective in reducing the acute and chronic complications of SCD, and the advantages and disadvantages of each methodology mean they all have a role in different situations. Evidence for the role of emergency transfusion in the management of the acute complications of SCD, including acute pain and acute chest syndrome, comes from observational data. Several important randomized controlled trials have shown the efficacy of transfusion in primary and secondary stroke prevention in patients with SCD but, outside these areas, clinical practice lacks a clear evidence base. Evidence for the role of long-term transfusion in the prevention of the non-neurologic chronic complications of SCD comes from analysis of secondary outcomes of these randomized trials and from observational data. In view of the paucity of data, the risks and benefits of transfusion should be fully discussed with patients/families before a long-term transfusion program is commenced. Evidence is only available for the role of preoperative transfusion or for prophylactic transfusion through pregnancy in certain situations, and the role of transfusions outside these situations is discussed. Questions about when and how to transfuse in SCD remain and will need further randomized trials to provide answers.

scholarly journals Indications for transfusion in the management of sickle cell disease

Hematology ◽  
2021 ◽  
Vol 2021 (1) ◽  
pp. 696-703
Author(s):  
Hyojeong Han ◽  
Lisa Hensch ◽  
Venée N. Tubman
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Perioperative Complications ◽  
Acute Chest Syndrome ◽  
Cell Disease ◽  
Transfusion Therapy ◽  
Frequent Use ◽  
Clinical Scenarios ◽  
Conclusive Data

Abstract The transfusion of red blood cells (RBCs) is a crucial treatment for sickle cell disease (SCD). While often beneficial, the frequent use of transfusions is associated with numerous complications. Transfusions should be offered with specific guidelines in mind. Here we present updates to the indications for transfusion of RBCs in SCD. We review recent publications and include expert perspectives from hematology and transfusion medicine. For some clinical indications, such as ischemic stroke, the role of transfusion has been well studied and can be applied almost universally. For many other clinical scenarios, the use of transfusion therapy has less conclusive data and therefore must be tailored to individual needs. We highlight the roles of RBC transfusions in preventing or mitigating neurological disease, in reducing perioperative complications, in managing acute chest syndrome, and in optimizing pregnancy outcomes in SCD. We further highlight various transfusion techniques and when each might be considered. Potential complications of transfusion are also briefly discussed.

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