Prolonged fever of unknown origin and hemophagocytosis evolving into acute lymphoblastic leukemia

2004 ◽  
Vol 76 (4) ◽  
pp. 364-367 ◽  
Author(s):  
Neta Goldschmidt ◽  
Alexander Gural ◽  
Abraham Kornberg ◽  
Galia Spectre ◽  
Andrei Shopen ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Fever Of Unknown Origin ◽  
Lymphoblastic Leukemia ◽  
Unknown Origin ◽  
Prolonged Fever

scholarly journals Hepatosplenic candidiasis in acute leukemia patients

2008 ◽  
Vol 136 (7-8) ◽  
pp. 414-418 ◽  
Author(s):  
Zoran Rajic ◽  
Natasa Colovic ◽  
Mirjana Sretenovic ◽  
Mira Plecic ◽  
Snezana Jankovic ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Fever Of Unknown Origin ◽  
Imaging Techniques ◽  
Lymphoblastic Leukemia ◽  
Elevated Serum ◽  
Unknown Origin ◽  
Antifungal Treatment ◽  
Prolonged Fever ◽  
Hepatosplenic Candidiasis ◽  
Main Clinical Manifestation

INTRODUCTION Hepatosplenic candidiasis is a disseminated invasive fungal infection that may affects patients with acute leukemia. The main clinical manifestation is a persistent fever in patients recovered from prolonged neutropenia after recent chemotherapy. CASE OUTLINE The authors present three patients, two women and one men, aged 23, 26 and 33 years, with acute leukemia; one with acute myeloblastic and two with acute lymphoblastic leukemia who developed hepatosplenic candidiasis. The diagnosis was based on prolonged fever, elevated serum bilirubin and alkaline phosphatase, as well as characteristic lesions on computed tomography, nuclear magnetic resonance and ultrasonographic findings and positive blood culture in one patient. The antifungal treatment was successful in one patient only. Two patients died due to progression of leukemia. CONCLUSION If leukemia patient in remission after chemotherapy develops a prolonged fever of unknown origin, hepatosplenic candidiasis has to be considered and all efforts should be done to diagnose it. The diagnosis is based on clinical presentation and imaging techniques. The positive cultures of fungi are not usually possible and are not mandatory. The antifungal treatment may be prolonged, sometimes 2 to 3 months or even more.

MALIGNANCY MASQUERADING AS JOINT INFECTION- A CASE REPORT

2021 ◽  
pp. 36-36
Author(s):  
Aparna C Babu ◽  
B. Manohar
Keyword(s):  
Case Report ◽  
Acute Lymphoblastic Leukemia ◽  
Childhood Leukemia ◽  
Lymphoblastic Leukemia ◽  
Joint Infection ◽  
Joint Effusion ◽  
Childhood Cancers ◽  
Prolonged Fever ◽  
Hematological Disorder ◽  
Common Malignancy

ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) is the most common malignancy in children. It accounts for 25% of all childhood cancers and approximately 75% of all cases of childhood leukemia. ALL presents usually with fever, lassitude, pallor, bone pains+/- bleeds. Here, we present a case of a child presenting with prolonged fever and swelling and pain in joints. Child was initially diagnosed as one hematological disorder and presented with joint effusion within a week.

Diagnostic Review : Prolonged Fever of Unknown Origin

1977 ◽  
Vol 16 (9) ◽  
pp. 768-773 ◽  
Author(s):  
Jacob A. Lohr ◽  
J. Owen Hendley
Keyword(s):  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Prolonged Fever

scholarly journals Etiology of fever of unknown origin in children.

2021 ◽  
Vol 28 (04) ◽  
pp. 552-556
Author(s):  
Aysha Mansoor Lodhi ◽  
Wajiha Rizwan ◽  
Mubeen Nazar ◽  
Asma Mushtaq ◽  
Muhammad Sahir Saud ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Lupus Erythematosus ◽  
Fever Of Unknown Origin ◽  
Lymphoblastic Leukemia ◽  
Unknown Origin ◽  
Connective Tissue Disorder ◽  
Definitive Diagnosis ◽  
Female Ratio ◽  
Qualitative Variables ◽  
Age Range

Objectives: To determine the etiology of Fever of Unknown Origin (FUO) in children. Study Design: Prospective Observational study. Setting: Department of Pediatric Medicine, The Children's Hospital, Lahore. Period: August 2019 to January 2020. Material & Methods: A total of 45 children aged between 01 to 180 months (15 years), having FUO were included. FUO was defined as a temperature of greater than 100.4ºF documented by a health care provider, persisting over a period of three weeks and for which no cause could be identified after at least 8 days of evaluation. All the study information was analyzed by using standard software SPSS 20. The quantitative variables like age and duration of fever before hospital admission were presented as mean and standard deviation. Qualitative variables like sex, antibiotic therapy use before definitive diagnosis and various diagnoses made were presented as frequencies and percentages. Results: The patient’s age range was from 01 to 180 months with mean of 80±45.12 months and male to female ratio was 2.2:1. Definitive diagnosis was made in 37(82.2%) patients. Infections were the predominant cause of FUO (44.4%) followed by malignancy (24.4%). Tuberculosis was the most common infection while Acute Lymphoblastic leukemia dominated the malignancy. Systemic lupus erythematosus was the most commonly diagnosed connective tissue disorder.  There was a significant association between duration of fever and the ultimate diagnosis (p=0.01). Conclusion: Infectious diseases were the most common cause of FUO followed by malignancy, connective tissue disorders and miscellaneous causes.

scholarly journals A study of etiology of fever of unknown origin in children aged 2 months to 18 years

2021 ◽  
Vol 8 (11) ◽  
pp. 1842
Author(s):  
Naveen Gandla ◽  
Sheela A. Bharani ◽  
Tushar P. Shah
Keyword(s):  
Enteric Fever ◽  
Fever Of Unknown Origin ◽  
Lymphoblastic Leukemia ◽  
Connective Tissue Diseases ◽  
Unknown Origin ◽  
Age Group ◽  
Antimicrobial Drugs ◽  
Cross Sectional ◽  
Female Ratio ◽  
Geographical Regions

Background: In an era of advance science of modern technologies, many diseases are diagnosed and excluded rapidly and now Fever of Unknown Origin (FUO) has been redefined for any fever of 380C lasting for more than 7 days without any clear cause. The aetiology varies according to different geographical regions, socioeconomical status, age, prevalence of resistance to antimicrobial drugs and genetic susceptibility.Methods: It was a descriptive cross sectional, hospital-based study, carried out on 150 children from August 2018 to May 2020. All cases in the age group of 2 months to 18 years with fever of >38.0°C, lasting for more than 7 days without a clear source were included.Results: The mean age of presentation was 5.8 years±Standard Deviation of 3.7 years with male to female ratio was 1.4:1. Nearly half of the cases, presented with the duration of fever between 8-14 days. Enteric fever in 52%, tuberculosis in 13.3% and acute lymphoblastic leukemia (ALL) in 8.5% were three common etiologies found in this study. Amongst all cases of FUO, infective causes were seen in 113 (75.3%) followed by malignancies in 15(10%) cases. In 10 (6.7%) cases, cause could not be established.Conclusions: Enteric fever and tuberculosis were the leading etiologies from infective subgroup of FUO. ALL was the commonest cause from malignancies sub group. FUO presenting with low haemoglobin, platelet is a pointer towards malignancy. Occurrence of FUO with infectious diseases and malignancies was found in younger age group as compared to connective tissue diseases. 

Is 111In-Leucocyte Scintigraphy Useful in the Evaluation of Patients with Prolonged Fever of Unknown Origin?

1994 ◽  
pp. 241-245
Author(s):  
K. Schmidt ◽  
I. M. Wedebye ◽  
B. Haastrup ◽  
J. W. Rasmussen ◽  
P. B. Frederiksen
Keyword(s):  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Leucocyte Scintigraphy ◽  
Prolonged Fever

Unusual Cause of Prolonged Fever of Unknown Origin

2017 ◽  
Vol 57 (2) ◽  
pp. 245-247
Author(s):  
Dionna Mathews ◽  
Pamela McMahon ◽  
Michael Bolton
Keyword(s):  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Prolonged Fever
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