scholarly journals Predictive value of QT dispersion for acute heart failure after autologous and allogeneic hematopoietic stem cell transplantation

2004 ◽  
Vol 76 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Hirohisa Nakamae ◽  
Masayuki Hino ◽  
Mika Akahori ◽  
Yoshiki Terada ◽  
Takahisa Yamane ◽  
...  
Keyword(s):  
Heart Failure ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Acute Heart Failure ◽  
Hematopoietic Stem Cell ◽  
Predictive Value ◽  
Qt Dispersion ◽  
Hematopoietic Stem

Heart failure after allogeneic hematopoietic stem cell transplantation

2013 ◽  
Vol 167 (6) ◽  
pp. 2502-2506 ◽  
Author(s):  
Xiao-Dong Mo ◽  
Lan-Ping Xu ◽  
Dai-Hong Liu ◽  
Xiao-Hui Zhang ◽  
Huan Chen ◽  
...  
Keyword(s):  
Heart Failure ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem

Abstract 72: Outcomes Of Patients With Left Ventricular Diastolic Dysfunction In Adult Hematopoietic Stem Cell Transplantation

2013 ◽  
Vol 6 (suppl_1) ◽  
Author(s):  
Kiran Garikapati ◽  
Syed Hassan ◽  
Aditi singhvi ◽  
Khoulani Dania ◽  
Sophia Qureshi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Diastolic Dysfunction ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Systolic Heart Failure ◽  
Left Ventricular ◽  
Hematopoietic Stem

Background: With better health care, hematopoietic stem cell transplantation has become possible for older patients. These patients have higher prevalence of diastolic dysfunction. However, it is not known if diastolic dysfunction has an impact on prognosis of these patients. Methods: Retrospective data was obtained for adults (>18 years) that underwent hematopoietic stem cell transplantation over a period of 1991 - 2012 (22 years). Demographic, echocardiogrpahic and mortality data were obtained. Cox proportional hazard model was used to analyze diastolic dysfunction as a predictor of mortality, graft versus host disease (GVHD), systolic heart failure (ejection fraction ≤50%) and sepsis. Diastolic dysfunction was defined according to American Society of Echocardiography guidelines. Results: Out of 770 patients (mean age 48.9±13.4, women 47.7%) had 91 (11.8%) patients with pre - transplant diastolic dysfunction. Patients with diastolic dysfunction were more likely to be older, hypertensive, ≥2 comorbidities and suffer from solid organ malignancy (p <0.05). Diastolic dysfunction was associated with GVHD (HR 2.69; 95% CI 1.42 - 5.10, p =0.002), post - transplant systolic heart failure (HR 3.25;95% CI 1.68 - 6.29, p=0.0001), 30 - day rehospitalizations (HR 1.81;95% CI 1.22 - 2.45, p = 0.003) and mortality (HR 2.62;95% CI 2.11 - 3.25, p = 0.0001). However, intensive care unit treatment, length of stay and sepsis were not associated with pre - transplant diastolic dysfunction. Conclusion: Pre - transplant diastolic dysfunction in this group of patients was associated with worse prognosis after transplantation. These findings might help guide therapies and early treatment/management of these patients, so that these complications might be prevented. <!--Copyright (c) 2006 Microsoft Corporation. All rights reserved.-->

scholarly journals β-d-Glucan Screening for Detection of Invasive Fungal Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

2015 ◽  
Vol 53 (8) ◽  
pp. 2605-2610 ◽  
Author(s):  
Antonia Koltze ◽  
Peter Rath ◽  
Stefan Schöning ◽  
Jörg Steinmann ◽  
Thomas A. Wichelhaus ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Positive Predictive Value ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Predictive Value ◽  
Invasive Fungal Disease ◽  
Fungal Disease ◽  
Hematopoietic Stem

While the assessment of β-d-glucan (BDG) levels in adults improves the early diagnosis of invasive fungal disease (IFD), data on BDG levels in children are limited. We therefore assessed in a prospective cohort study the value of serial BDG screening for early detection of IFD in children undergoing allogeneic hematopoietic stem cell transplantation (HSCT). IFD was defined according to the revised European Organization for Research and Treatment of Cancer/Mycosis Study Group (EORTC/MSG) criteria, with the necessary modification that BDG was not included as a microbiological criterion. For the analysis, a total of 702 serum samples were obtained in 34 pediatric HSCT recipients. Proven IFD occurred in two patients (fusariosis andCandidasepsis, respectively), and probable invasive aspergillosis was diagnosed in four patients. Analyses including different cutoff values for BDG levels and different definitions of the onset of IFD demonstrated that the BDG assay has a relatively high sensitivity and good negative predictive value, whereas the positive predictive value has major limitations (<30%). Receiver operating characteristic analyses suggested an optimal cutoff between 60 and 70 pg/ml for different definitions of the onset of IFD. Our data show that BDG screening in pediatric HSCT recipients has a low positive predictive value and is therefore of limited usefulness.

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