scholarly journals Polymorphisms within the angiotensinogen gene (GT-Repeat) and the risk of stroke in pediatric patients with sickle cell disease: A case-control study

2001 ◽  
Vol 68 (3) ◽  
pp. 164-169 ◽  
Author(s):  
Delia C. Tang ◽  
Ron Prauner ◽  
Wenli Liu ◽  
Kye-Hyun Kim ◽  
Robert P. Hirsch ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Pediatric Patients ◽  
Case Control Study ◽  
Case Control ◽  
Cell Disease ◽  
Angiotensinogen Gene ◽  
Control Study

scholarly journals The association between dental and periodontal diseases and sickle cell disease. A pilot case-control study

2015 ◽  
Vol 27 (1) ◽  
pp. 40-43 ◽  
Author(s):  
Haidar Al-Alawi ◽  
Abdulfatah Al-Jawad ◽  
Mahdi Al-Shayeb ◽  
Ali Al-Ali ◽  
Khalifa Al-Khalifa
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Case Control Study ◽  
Periodontal Diseases ◽  
Case Control ◽  
Cell Disease ◽  
Control Study

Hematological and Clinical Findings Predictive of Mortality in Italian Patients with Sickle-Cell Disease: A Case-Control Study.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 3780-3780
Author(s):  
Aurelio Maggio ◽  
Veronica Di Salvo ◽  
Paolo Rigano ◽  
Antonino Giangreco ◽  
Maria Concetta Renda ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Causes Of Death ◽  
Case Control Study ◽  
Case Control ◽  
Clinical Findings ◽  
Cell Disease ◽  
Previous Stroke ◽  
Wbc Count ◽  
Control Study

Abstract Background: the number of cases with Sickle-Cell Disease (SCD) registered in Italy at 2000 was 928. Six-hundred-twenty-two (67%) of these were with Sickle-Cell/βthalassemia. Moreover, while the main causes of death in Afro-American patients with SCD is well known, we do not have many informations in Italian subjects. For this reason, we carried ahead a case-control study in this group of patients. Aim of the study: the evaluation of the main hematological and clinical parameters predictive of mortality. Materials and Methods: clinical and hematological findings of 14 SCD died patients were compared with a SCD alive control population homogeneous for age, sex, phenotype and number of painful crises per year. Two alive control subjects were studied for each died patient. Results: the main causes of death were: Acute Chest Syndromes (ACS) (n°6), Cardiovascular Diseases (n°3),Hepatic Failure (n°1),Hodgkin Lymphoma (n°1), Stroke (n°1), Lung Cancer (n°1), Surgery Complication (n°1). The main correlated hematological findings with mortality were Hb (gr/dl) levels (p=<.05), WBC count (103 / ml) (p= <.05), ferritin levels (ng/ml) (p=<.01). The main correlated clinical features were: the number of crises >3/year (Odd Ratio= 1.64; p= <.01), previous stroke (Odd Ratio= 1.53; p= <.01), HU treatment (Odd Ratio=<.01; p=<.01), leg ulcers (Odd Ratio=1.46;p=<.01). Conclusions: these data suggest that the main causes of death in Italian patients with SCD are similar to those reported for Afro-American subjects (M.H. Steinberg, JAMA, April 2, Vol. 289, N°13, 1645–1651). Particularly, the lack of HU treatment, anemia, high ferritin levels, number of crises per year and previous stroke are the most important predictive factors of mortality.

scholarly journals Interleukin 6 as a marker of severe bacterial infection in children with sickle cell disease and fever: a case–control study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Elena María Rincón-López ◽  
María Luisa Navarro Gómez ◽  
Teresa Hernández-Sampelayo Matos ◽  
David Aguilera-Alonso ◽  
Eva Dueñas Moreno ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Bacterial Infection ◽  
Sickle Cell ◽  
Case Control Study ◽  
Case Control ◽  
Cell Disease ◽  
Severe Bacterial Infection ◽  
Tnf Α ◽  
Significant Difference ◽  
Control Study

Abstract Background Etiological diagnosis of fever in children with sickle cell disease (SCD) is often challenging. The aim of this study was to analyze the pattern of inflammatory biomarkers in SCD febrile children and controls, in order to determine predictors of severe bacterial infection (SBI). Methods A prospective, case–control study was carried out during 3 years, including patients younger than 18 years with SCD and fever (cases) and asymptomatic steady-state SCD children (controls). Clinical characteristics and laboratory parameters, including 10 serum proinflammatory cytokines (IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-17a, IFN-γ and TNF-α) and comparisons among study subgroups were analyzed. Results A total of 137 patients (79 cases and 58 controls) were included in the study; 78.5% males, median age 4.1 (1.7–7.5) years. Four cases were diagnosed with SBI, 41 viral infection (VI), 33 no proven infection (NPI) and 1 bacterial-viral coinfection (the latter excluded from the subanalyses). IL-6 was significantly higher in patients with SBI than in patients with VI or NPI (163 vs 0.7 vs 0.7 pg/ml, p < 0.001), and undetectable in all controls. The rest of the cytokines analyzed did not show any significant difference. The optimal cut-off value of IL-6 for the diagnosis of SBI was 125 pg/mL, with high PPV and NPV (PPV of 100% for a prevalence rate of 5, 10 and 15% and NPV of 98.7%, 97.3% and 95.8% for those prevalences rates, respectively). Conclusion We found that IL-6 (with a cut-off value of 125 pg/ml) was an optimal marker for SBI in this cohort of febrile SCD children, with high PPV and NPV. Therefore, given its rapid elevation, IL-6 may be useful to early discriminate SCD children at risk of SBI, in order to guide their management.

Investigation of the relationship between periodontal and systemic inflammation in children with Sickle Cell Disease: A case- control study

Cytokine ◽  
2022 ◽  
Vol 149 ◽  
pp. 155724
Author(s):  
Mine Öztürk Tonguç ◽  
Candan Öztürk ◽  
Gürbüz Polat ◽  
Onur Bobuşoğlu ◽  
Sebahat Aslan Tek ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Systemic Inflammation ◽  
Case Control Study ◽  
Case Control ◽  
Cell Disease ◽  
The Relationship ◽  
Control Study
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