scholarly journals Acquired activated protein C resistance, high tissue factor expression, and hyper-homocysteinemia in systemic lupus erythematosus

2003 ◽  
Vol 72 (2) ◽  
pp. 103-108 ◽  
Author(s):  
D. Oh ◽  
S.H. Kim ◽  
M.S. Kang ◽  
N.K. Kim ◽  
N.S. Chang ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Tissue Factor ◽  
Lupus Erythematosus ◽  
Protein C ◽  
Activated Protein C ◽  
Tissue Factor Expression ◽  
Activated Protein C Resistance ◽  
Systemic Lupus ◽  
Factor Expression

Acquired activated protein C resistance is associated with lupus anticoagulants and thrombotic events in pediatric patients with systemic lupus erythematosus

Blood ◽  
2001 ◽  
Vol 97 (4) ◽  
pp. 844-849 ◽  
Author(s):  
Christoph Male ◽  
Lesley Mitchell ◽  
James Julian ◽  
Patricia Vegh ◽  
Penny Joshua ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Protein C ◽  
Pediatric Patients ◽  
Activated Protein C ◽  
Factor V Leiden ◽  
Protein S ◽  
Activated Protein C Resistance ◽  
Systemic Lupus ◽  
Lupus Anticoagulants

Abstract Acquired activated protein C resistance (APCR) has been hypothesized as a possible mechanism by which antiphospholipid antibodies (APLAs) cause thrombotic events (TEs). However, available evidence for an association of acquired APCR with APLAs is limited. More importantly, an association of acquired APCR with TEs has not been demonstrated. The objective of the study was to determine, in pediatric patients with systemic lupus erythematosus (SLE), whether (1) acquired APCR is associated with the presence of APLAs, (2) APCR is associated with TEs, and (3) there is an interaction between APCR and APLAs in association with TEs. A cross-sectional cohort study of 59 consecutive, nonselected children with SLE was conducted. Primary clinical outcomes were symptomatic TEs, confirmed by objective radiographic tests. Laboratory testing included lupus anticoagulants (LAs), anticardiolipin antibodies (ACLAs), APC ratio, protein S, protein C, and factor V Leiden. The results revealed that TEs occurred in 10 (17%) of 59 patients. Acquired APCR was present in 18 (31%) of 58 patients. Acquired APCR was significantly associated with the presence of LAs but not ACLAs. Acquired APCR was also significantly associated with TEs. There was significant interaction between APCR and LAs in the association with TEs. Presence of both APCR and LAs was associated with the highest risk of a TE. Protein S and protein C concentrations were not associated with the presence of APLAs, APCR, or TEs. Presence of acquired APCR is a marker identifying LA-positive patients at high risk of TEs. Acquired APCR may reflect interference of LAs with the protein C pathway that may represent a mechanism of LA-associated TEs.

Acquired activated protein C resistance is associated with IgG antibodies to protein S in patients with systemic lupus erythematosus

2009 ◽  
Vol 124 (1) ◽  
pp. 127-131 ◽  
Author(s):  
Junzo Nojima ◽  
Yoshinori Iwatani ◽  
Kiyoshi Ichihara ◽  
Hidehiro Tsuneoka ◽  
Toshizo Ishikawa ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Protein C ◽  
Activated Protein C ◽  
Protein S ◽  
Igg Antibodies ◽  
Activated Protein C Resistance ◽  
Systemic Lupus

Clinical significance of acquired activated protein C resistance in patients with systemic lupus erythematosus

Lupus ◽  
2002 ◽  
Vol 11 (11) ◽  
pp. 730-735 ◽  
Author(s):  
F-J Muñoz-Rodríguez ◽  
J-C Reverter ◽  
J Font ◽  
D Tàssies ◽  
G Espinosa ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Clinical Significance ◽  
Lupus Erythematosus ◽  
Protein C ◽  
Activated Protein C ◽  
Activated Protein C Resistance ◽  
Systemic Lupus

Resistance to activated protein C in systemic lupus erythematosus patients with antiphospholipid antibodies

2009 ◽  
Vol 53 (3) ◽  
pp. 188-189 ◽  
Author(s):  
Juzo Matsuda ◽  
Kengo Gohchi ◽  
Miyo Tsukamoto ◽  
Moritaka Gotoh ◽  
Noriko Saitoh ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antiphospholipid Antibodies ◽  
Protein C ◽  
Activated Protein C ◽  
Systemic Lupus

scholarly journals Activated protein C suppresses tissue factor expression on U937 cells in the endothelial protein C receptor-dependent manner

FEBS Letters ◽  
2000 ◽  
Vol 477 (3) ◽  
pp. 208-212 ◽  
Author(s):  
Fang Shu ◽  
Hiroshi Kobayashi ◽  
Kenji Fukudome ◽  
Naoko Tsuneyoshi ◽  
Masao Kimoto ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Protein C ◽  
Activated Protein C ◽  
Dependent Manner ◽  
U937 Cells ◽  
Tissue Factor Expression ◽  
Endothelial Protein C Receptor ◽  
Factor Expression
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