Effects of early partial decapitation on the ontogenic development of chicken lymphoid organs. I. Thymus

1991 ◽  
Vol 191 (1) ◽  
pp. 57-66 ◽  
Author(s):  
P. G. Herradón ◽  
B. Razquin ◽  
A. G. Zapata
Keyword(s):  
Lymphoid Organs ◽  
Ontogenic Development

scholarly journals Ontogenic development of immunoglobulins (Igs)-positive lymphocytes in the lymphoid organs of native chickens of Bangladesh

2013 ◽  
Vol 1 (2) ◽  
pp. 96-101 ◽  
Author(s):  
Md. Nabiul Islam ◽  
Mohammed Zahirul Islam Khan ◽  
Mir Rubayet Jahan ◽  
Ryutaro Fujinaga ◽  
Koh Shinoda
Keyword(s):  
Lymphoid Organs ◽  
Ontogenic Development ◽  
Native Chickens

scholarly journals Histological studies on ontogenic development of lymphoid organs in Indian major carp, Catla catla

2019 ◽  
Vol 40 (2) ◽  
pp. 151-157 ◽  
Author(s):  
P. Arya ◽  
◽  
P.K. Pradhan ◽  
R. Sharma ◽  
N. Sood ◽  
...  
Keyword(s):  
Lymphoid Organs ◽  
Catla Catla ◽  
Indian Major Carp ◽  
Histological Studies ◽  
Ontogenic Development

Minimal contribution of cell-bound antibodies to the immunoscintigraphy of inflamed joints with 99mTc-anti-CD4 monoclonal antibodies

2002 ◽  
Vol 41 (03) ◽  
pp. 129-134 ◽  
Author(s):  
A. Wolski ◽  
E. Palombo-Kinne ◽  
F. Wolf ◽  
F. Emmrich ◽  
W. Becker ◽  
...  
Keyword(s):  
T Cells ◽  
Monoclonal Antibodies ◽  
Synovial Membrane ◽  
In Vitro Release ◽  
Peritoneal Macrophages ◽  
Lymphoid Organs ◽  
Whole Body ◽  
Free Form ◽  
Ankle Joints

Summary Aim: The cellular joint infiltrate in rheumatoid arthritis patients is rich in CD4-positive T-helper lymphocytes and macrophages, rendering anti-CD4 monoclonal antibodies (mAbs) suitable for specific immunoscintigraphy of human/ experimental arthritis. Following intravenous injection, however, mAbs are present both in the free form and bound to CD4-positive, circulating monocytes and T-cells. Thus, the present study aimed at analyzing the relative contribution of the free and the cell-bound component to the imaging of inflamed joints in experimental adjuvant arthritis (AA). Methods: AA rat peritoneal macrophages or lymph node T-cells were incubated in vitro with saturating amounts of 99mTc-anti-CD4 mAb (W3/25) and injected i.v. into rats with AA. Results: In vitro release of 99mTc-anti-CD4 mAb from the cells was limited (on average 1.57%/h for macrophages and 0.84%/h for T-cells). Following i.v. injection, whole body/joint scans and tissue measurements showed only negligible accumulation of radioactivity in inflamed ankle joints (tissue: 0.22 and 0.34% of the injected activity, respectively), whereas the radioactivity was concentrated in liver (tissue: 79% and 71%, respectively), kidney, and urinary bladder. Unlike macrophages, however, anti-CD4 mAb-coated T-cells significantly accumulated in lymphoid organs, the inflamed synovial membrane of the ankle joints, as well as in elbow and knee joints. Conclusion: While the overall contribution of cell-bound mAbs to the imaging of arthritic joints with anti-CD4 mAbs is minimal, differential accumulation of macrophages and T-cells in lymphoid organs and the inflamed synovial membrane indicates preferential migration patterns of these 2 cell populations in arthritic rats. Although only validated for 99mTc-anti-CD4 mAbs, extrapolation of the results to other anticellular mAbs with similar affinity for their antigen may be possible.

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