The development of the sinusoids of fetal rat liver: Morphology of endothelial cells, Kupffer cells, and the transmural migration of blood cells into the sinusoids

1980 ◽  
Vol 159 (1) ◽  
pp. 1-15 ◽  
Author(s):  
Patrick W. Bankston ◽  
Richard M. Pino
Keyword(s):  
Endothelial Cells ◽  
Rat Liver ◽  
Kupffer Cells ◽  
Blood Cells ◽  
Fetal Rat ◽  
Transmural Migration ◽  
Fetal Rat Liver ◽  
Liver Morphology

Endogenous Peroxidase Localization in Kupffer Cells of the Fetal Rat Liver

1977 ◽  
Vol 35 ◽  
pp. 424-425
Author(s):  
Richard M. Pino
Keyword(s):  
Rat Liver ◽  
Kupffer Cells ◽  
Wistar Rat ◽  
Adult Liver ◽  
Ether Anesthesia ◽  
Fetal Rat ◽  
Endogenous Peroxidase ◽  
Sinusoidal Endothelium ◽  
Fetal Rat Liver ◽  
Adult Bone

This study confirms the presence of endogenous peroxidase in fetal Kupffer cells. In adult hepatic sinusoids Kupffer cells are peroxidase positive; endothelial cells are not.1 The fetal rat liver sinusoidal endothelium during development changes from a lining similar to that found in adult bone marrow to an adult liver type.2 Cells that resemble adult Kupffer cells are evident at 13 days gestation and can endocytize carbon beginning at 14 days.Sixteen day Wistar rat fetuses were exposed in utero after ether anesthesia of their mothers. Colloidal carbon (Pelikan, Gunther Wagner) diluted 1:1 with double strength Tyrode1s solution, or as a control, single strength Tyrode's solution without carbon, was injected (0.01-0,03ml) into the fetal umbilical veins with a 30 gauge needle.2 After allowing one minute for the injected material to circulate, the fetuses were decapitated and the livers were removed and diced into small pieces.

Involvement of signaling of VEGF and TGF-β in differentiation of sinusoidal endothelial cells during culture of fetal rat liver cells

2007 ◽  
Vol 329 (2) ◽  
pp. 273-282 ◽  
Author(s):  
Masayuki Yoshida ◽  
Yuji Nishikawa ◽  
Yasufumi Omori ◽  
Toshiaki Yoshioka ◽  
Takuo Tokairin ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Rat Liver ◽  
Liver Cells ◽  
Sinusoidal Endothelial Cells ◽  
Fetal Rat ◽  
Rat Liver Cells ◽  
Fetal Rat Liver

scholarly journals The development of the sinusoids of fetal rat liver: localization of endogenous peroxidase in fetal Kupffer cells.

1979 ◽  
Vol 27 (2) ◽  
pp. 643-652 ◽  
Author(s):  
R M Pino ◽  
P W Bankston
Keyword(s):  
Rat Liver ◽  
Kupffer Cells ◽  
Serial Sections ◽  
Adult Liver ◽  
Monocytic Cells ◽  
Dense Bodies ◽  
Fetal Rat ◽  
Endogenous Peroxidase ◽  
Fetal Rat Liver ◽  
Cytochemical Marker

Endogenous peroxidase is the cytochemical marker used to identify Kupffer cells in the adult liver. In this study, we show by ultrastructural cytochemistry that Kupffer cells of the fetal rat liver are endogenous peroxidase positive. The reaction product is localized in the endoplasmic reticulum including the perinuclear cisternae and in a few lysosome-like dense bodies. Serial sections of Golgi regions suggest that GERL and not the Golgi stacks, is peroxidase positive. As in the adult liver, peroxidase is not localized in endothelial cells. Kupffer cells do not appear to transform from endothelial or extravascular developing monocytic cells and are present prior to bone marrow formation. The relevance of these observations with respect to the possible origin of the Kupffer cell is discussed.

Effects of Steroids on Fetal Rat Liver

1969 ◽  
Vol 27 ◽  
pp. 350-351
Author(s):  
F. G. Zaki
Keyword(s):  
Liver Injury ◽  
Rat Liver ◽  
Fetal Liver ◽  
Dosage Level ◽  
Maternal Plasma ◽  
Methyl Prednisolone ◽  
Fetal Rat ◽  
Toxic Agents ◽  
Fetal Rat Liver ◽  
Neonatal Liver

Fetal and neonatal liver injury induced by agents circulating in maternal plasma, even though well recognized, its morphological manifestations are not yet established. As part of our studies of fetal and neonatal liver injury induced by maternal nutritional disorders, metabolic impairment and toxic agents, the effects of two anti-inflammatory steroids have been recently inves tigated.Triamcinolone and methyl prednisolone were injected each in a group of rats during pregnancy at a-dosage level of 2 mgm three times a week. Fetal liver was studied at 18 days of gestation. Litter size and weight markedly decreased than those of control rats. Stillbirths and resorption were of higher incidence in the triamcinolone group than in those given the prednisolone.

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