Development of type I cells of the rabbit subclavian glomera (aortic bodies): A light, fluorescence and electron microscopic study

1978 ◽  
Vol 153 (1) ◽  
pp. 15-31 ◽  
Author(s):  
John T. Hansen
Keyword(s):  
Microscopic Study ◽  
Electron Microscopic Study ◽  
Type I ◽  
Electron Microscopic ◽  
Type I Cells ◽  
Light Fluorescence ◽  
I Cells

Congenital dyserythropoietic anemia type I: A freeze-fracture and thin section electron microscopic study

1983 ◽  
Vol 46 (6) ◽  
pp. 329-338 ◽  
Author(s):  
Akira Hiraoka ◽  
Yoshio Kanayama ◽  
Takeshi Yonezawa ◽  
Teruo Kitani ◽  
Seiichiro Tarui ◽  
...  
Keyword(s):  
Microscopic Study ◽  
Thin Section ◽  
Electron Microscopic Study ◽  
Freeze Fracture ◽  
Type I ◽  
Electron Microscopic ◽  
Congenital Dyserythropoietic Anemia ◽  
Section Electron

Respiratory epithelial permeability after cigarette smoke exposure in guinea pigs

1989 ◽  
Vol 66 (5) ◽  
pp. 2109-2116 ◽  
Author(s):  
A. R. Burns ◽  
S. P. Hosford ◽  
L. A. Dunn ◽  
D. C. Walker ◽  
J. C. Hogg
Keyword(s):  
Cigarette Smoke ◽  
Guinea Pigs ◽  
Alveolar Epithelium ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Gel Chromatography ◽  
Type I ◽  
Electron Microscopic ◽  
Type I Cells ◽  
I Cells

The purpose of this study was to determine the pathology of cigarette smoke-increased permeability at the bronchioalveolar junction of the guinea pig. After exposure to either smoke or room air, guinea pigs were anesthetized and fluorescein isothiocyanate-dextran (FITC-D, mol wt 10,000) was aerosolized into their lungs. Blood samples taken through a carotid arterial cannula were analyzed by gel chromatography and spectrofluorometry for the presence of FITC-D. The results confirmed that, after smoke exposure, increased amounts of intact FITC-D molecules with a reported Einstein-Stokes radius of 22.2 A crossed the respiratory epithelium into the vascular space. Transmission electron-microscopic studies showed that the FITC-D diffused across damaged type I pneumocyte membranes and cytoplasm to reach the basal lamina and entered the alveolar capillaries through endothelial tight junctions. Damage to the alveolar epithelium was more frequent for the smoke-exposed animals than the room air-exposed animals (P less than 0.05). We conclude that smoke exposure damages type I cells and that inhaled FITC-D crosses the epithelial barrier at damaged type I cells of the bronchioloalveolar junctions.

scholarly journals A neonatal secretory protein associated with secretion granule membranes in developing rat salivary glands.

1991 ◽  
Vol 39 (12) ◽  
pp. 1693-1706 ◽  
Author(s):  
W D Ball ◽  
A R Hand ◽  
J E Moreira
Keyword(s):  
Acinar Cells ◽  
Secretory Protein ◽  
Postnatal Life ◽  
Type I ◽  
Secretion Granule ◽  
Electron Microscopic ◽  
Type Iii ◽  
Type I Cells ◽  
Secretion Granules ◽  
I Cells

In the perinatal submandibular gland, the secretion granules of Type I cells contain protein C (89 KD) and those of Type III cells have Bl-immunoreactive proteins (Bl-IP, 23.5-27.5 KD). In this report we used immunocytochemistry at the light and electron microscopic levels to describe the developmental distribution and localization of protein D (175 KD), which is secreted by both Type I and Type III cells. At its first appearance in Type I cells at 18 days and in Type III cells at 19 days post conception, protein D immunoreactivity (D-IR) is associated with secretion granule membranes; this is more pronounced in Type I than in Type III cells. In early postnatal life the label remains membrane associated, but as Type III cells differentiate into seromucous acinar cells, the lower level of label present in these cells is found in the granule content. Label is found associated with the membrane in secretion granules of Type I cells as long as these cells are identifiable in acini, and subsequent to this similarly labeled cells are seen in intercalated ducts. In the sublingual gland (SLG), D-IR is membrane associated in secretion granules of serous demilune cells, and is present in the secretion granule content in mucous acinar cells. D-IR is also found in the lingual serous (von Ebner's) glands, lacrimal gland, and tracheal glands, primarily in the ducts, where it is localized in the content of secretion granules.

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