Kinetics of particle formation in the gas antisolvent precipitation process

AIChE Journal ◽  
2003 ◽  
Vol 49 (4) ◽  
pp. 859-868 ◽  
Author(s):  
Nicola Elvassore ◽  
Tiziana Parton ◽  
Alberto Bertucco ◽  
Vito Di Noto
Keyword(s):  
Particle Formation ◽  
Precipitation Process ◽  
Antisolvent Precipitation ◽  
Gas Antisolvent ◽  
Kinetics Of

Antisolvent Precipitation of PDI 747:  Kinetics of Particle Formation and Growth

2007 ◽  
Vol 7 (9) ◽  
pp. 1653-1661 ◽  
Author(s):  
Jochen Schöll ◽  
Christian Lindenberg ◽  
Lars Vicum ◽  
Marco Mazzotti ◽  
Jörg Brozio
Keyword(s):  
Particle Formation ◽  
Antisolvent Precipitation ◽  
Kinetics Of ◽  
Particle Formation And Growth

scholarly journals Enhanced Water Solubility and Oral Bioavailability of Paclitaxel Crystal Powders through an Innovative Antisolvent Precipitation Process: Antisolvent Crystallization Using Ionic Liquids as Solvent

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1008 ◽  
Author(s):  
Qilei Yang ◽  
Chang Zu ◽  
Wengang Li ◽  
Weiwei Wu ◽  
Yunlong Ge ◽  
...  
Keyword(s):  
Oral Bioavailability ◽  
High Performance ◽  
Water Solubility ◽  
Water Soluble ◽  
Precipitation Process ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
Antisolvent Precipitation ◽  
Antisolvent Crystallization ◽  
Artificial Gastric Juice

Paclitaxel (PTX) is a poor water-soluble antineoplastic drug with significant antitumor activity. However, its low bioavailability is a major obstacle for its biomedical applications. Thus, this experiment is designed to prepare PTX crystal powders through an antisolvent precipitation process using 1-hexyl-3-methylimidazolium bromide (HMImBr) as solvent and water as an antisolvent. The factors influencing saturation solubility of PTX crystal powders in water in water were optimized using a single-factor design. The optimum conditions for the antisolvent precipitation process were as follows: 50 mg/mL concentration of the PTX solution, 25 °C temperature, and 1:7 solvent-to-antisolvent ratio. The PTX crystal powders were characterized via scanning electron microscopy, Fourier transform infrared spectroscopy, high-performance liquid chromatography–mass spectrometry, X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, Raman spectroscopy, solid-state nuclear magnetic resonance, and dissolution and oral bioavailability studies. Results showed that the chemical structure of PTX crystal powders were unchanged; however, precipitation of the crystalline structure changed. The dissolution test showed that the dissolution rate and solubility of PTX crystal powders were nearly 3.21-folds higher compared to raw PTX in water, and 1.27 times higher in artificial gastric juice. Meanwhile, the bioavailability of PTX crystal increased 10.88 times than raw PTX. These results suggested that PTX crystal powders might have potential value to become a new oral PTX formulation with high bioavailability.

Kinetics of Sol Particle Formation as a Function of pH Studied by Viscosity Measurements in Silica Solutions

Langmuir ◽  
2002 ◽  
Vol 18 (8) ◽  
pp. 3027-3033 ◽  
Author(s):  
Wolfram Vogelsberger ◽  
Andreas Seidel ◽  
Tilo Breyer
Keyword(s):  
Particle Formation ◽  
Viscosity Measurements ◽  
Kinetics Of

scholarly journals Physicochemical Properties and In Vitro Dissolution of Spiramycin Microparticles Using the Homogenate-Antisolvent Precipitation Process

2016 ◽  
Vol 7 (1) ◽  
pp. 10 ◽  
Author(s):  
Xiaonan Zhang ◽  
Xia Wu ◽  
Fengying Xie ◽  
Zhongjiang Wang ◽  
Xiuling Zhang ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
In Vitro Dissolution ◽  
Precipitation Process ◽  
Antisolvent Precipitation

The kinetics of aerosol particle formation and removal in NPP severe accidents

2016 ◽  
Author(s):  
Mikhail A. Zatevakhin ◽  
Valentin K. Arefiev ◽  
Sergey E. Semashko ◽  
Rostislav A. Dolganov
Keyword(s):  
Aerosol Particle ◽  
Particle Formation ◽  
Severe Accidents ◽  
Kinetics Of

Kinetics of particle growth. III. Particle formation in the photolysis of sulfur dioxide-acetylene mixtures

1974 ◽  
Vol 78 (4) ◽  
pp. 325-335 ◽  
Author(s):  
Menachem Luria ◽  
Rosa G. De Pena ◽  
Kenneth J. Olszyna ◽  
Julian Heicklen
Keyword(s):  
Sulfur Dioxide ◽  
Particle Growth ◽  
Particle Formation ◽  
Kinetics Of

Semibatch Gas Antisolvent Precipitation of Poly(2,6-dimethyl-1,4-phenylene ether)

1997 ◽  
pp. 242-253 ◽  
Author(s):  
F. E. Wubbolts ◽  
R. E. A. Buijsse ◽  
O. S. L. Bruinsma ◽  
J. de Graauw ◽  
G. M. van Rosmalen
Keyword(s):  
Antisolvent Precipitation ◽  
Gas Antisolvent
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