Effect of geometry on the dissolution of pharmaceutical tablets and other solids: Surface detachment kinetics controlling

AIChE Journal ◽  
1972 ◽  
Vol 18 (2) ◽  
pp. 446-449 ◽  
Author(s):  
David O. Cooney
Keyword(s):  
Pharmaceutical Tablets ◽  
Surface Detachment

scholarly journals UV/Vis absorption spectroelectrochemistry of folic acid

2021 ◽  
Author(s):  
F. Olmo ◽  
A. Rodriguez ◽  
A. Colina ◽  
A. Heras
Keyword(s):  
Folic Acid ◽  
Optical Signal ◽  
Oxidation Products ◽  
Basic Medium ◽  
Analytical Technique ◽  
Pharmaceutical Tablets ◽  
Solution Interface ◽  
Vitamin B9 ◽  
Analytical Protocol ◽  
Parallel Configuration

AbstractUV/Vis absorption spectroelectrochemistry is a very promising analytical technique due to the complementary information that is simultaneously obtained from electrochemistry and spectroscopy. In this work, this technique is used in a parallel configuration to study the oxidation of folic acid in alkaline medium. Herein, UV/Vis absorption spectroelectrochemistry has been used to detect both the oxidation products and the folic acid consumed at the electrode/solution interface, allowing us to develop an analytical protocol to quantify vitamin B9 in pharmaceutical tablets. Linear ranges of three orders of magnitude have been achieved in basic medium (pH = 12.9), obtaining high repeatability and low detection limits. The spectroelectrochemical determination of folic acid in pharmaceutical tablets at alkaline pH values is particularly interesting because of the changes that occur in the optical signal during the electrochemical oxidation of FA, providing results with very good figures of merit and demonstrating the utility and versatility of this hyphenated technique, UV/Vis absorption spectroelectrochemistry.

scholarly journals Determination of drug, excipients and coating distribution in pharmaceutical tablets using NIR-CI

2012 ◽  
Vol 2 (2) ◽  
pp. 90-97 ◽  
Author(s):  
Anna Palou ◽  
Jordi Cruz ◽  
Marcelo Blanco ◽  
Jaume Tomàs ◽  
Joaquín de los Ríos ◽  
...  
Keyword(s):  
Pharmaceutical Tablets

Photochemical stability of warfarin potassium in powdered pharmaceutical tablets

2021 ◽  
Vol 32 (2) ◽  
pp. 115-129
Author(s):  
Emi Horiguchi-Babamoto ◽  
Makoto Otsuka
Keyword(s):  
High Performance ◽  
Partial Least Squares Regression ◽  
Pediatric Patients ◽  
Reversed Phase ◽  
Least Squares Regression ◽  
Brand Name ◽  
Pharmaceutical Tablets ◽  
Light Stability ◽  
Warfarin Potassium ◽  
The Stability

BACKGROUND: Warfarin potassium (Wf) commercial tablets originally formulated for adults are ground before administration to pediatric patients and elderly patients with dysphagia. OBJECTIVE: The present study investigated the effect of tablet grinding on the photostability of four types of commercial Wf tablets and predicted the photostability of the tablet powders by chemometric analysis. METHODS: The photodegradation of Wf content was evaluated by reversed-phase column high-performance liquid chromatography with ultraviolet (HPLC-UV). RESULTS: The bulk Wf powder was relatively photostable, whereas ground Wf tablets underwent substantial photodegradation. The photostability of the ground powders of a brand-name Wf commercial tablet and three generic Wf commercial tablets was quantitatively assessed and compared. In certain cases, the Wf in all the three ground generic tablets was less photostable than in the ground brand-name tablets. After 28 days of light irradiation, the Wf content decreased to 69.79% in the brand-name tablets, while it was 31.90% in some generic tablets. To clarify the factors influencing the relative photostability in various Wf formulations, we analyzed the intermolecular interactions between the active ingredient and the excipients by partial least-squares regression analysis based on photostability screening for each additive. CONCLUSION: The results suggested that the additives light anhydrous silicic acid and povidone adversely affect the stability of Wf tablets. In addition, the light stability of ground tablets was affected considerably by their formulation.

scholarly journals Terahertz-Based Porosity Measurement of Pharmaceutical Tablets: a Tutorial

2020 ◽  
Vol 41 (4) ◽  
pp. 450-469 ◽  
Author(s):  
Prince Bawuah ◽  
Daniel Markl ◽  
Daniel Farrell ◽  
Mike Evans ◽  
Alessia Portieri ◽  
...  
Keyword(s):  
Pharmaceutical Tablets

Heterostructures of mesoporous TiO2 and SnO2 nanocatalyst for improved electrochemical oxidation ability of vitamin B6 in pharmaceutical tablets

2019 ◽  
Vol 542 ◽  
pp. 45-53 ◽  
Author(s):  
Devaraj Manoj ◽  
Saravanan Rajendran ◽  
Jiaqian Qin ◽  
Elumalai Sundaravadivel ◽  
Mehmet Lütfi Yola ◽  
...  
Keyword(s):  
Electrochemical Oxidation ◽  
Vitamin B6 ◽  
Mesoporous Tio2 ◽  
Pharmaceutical Tablets

Simultaneous Determination of Ibuprofen and Pseudoephedrine Hydrochloride in Pharmaceutical Tablets by Reversed-Phase HPLC

2009 ◽  
Vol 42 (18) ◽  
pp. 2951-2961 ◽  
Author(s):  
Marie-Hélène Langlois ◽  
Philippe Dallet ◽  
Tina Kauss ◽  
Jean-Pierre Dubost
Keyword(s):  
Simultaneous Determination ◽  
Reversed Phase ◽  
Reversed Phase Hplc ◽  
Pharmaceutical Tablets

A new generation starch product as excipient in pharmaceutical tablets

1997 ◽  
Vol 157 (2) ◽  
pp. 181-187 ◽  
Author(s):  
G.H.P. Te Wierik ◽  
A.C. Eissens ◽  
J. Bergsma ◽  
A.W. Arends-Scholte ◽  
G.K. Bolhuis
Keyword(s):  
Pharmaceutical Tablets ◽  
New Generation
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