Improving mixing performance by curved‐blade static mixer

AIChE Journal ◽  
2020 ◽  
Vol 66 (11) ◽  
Author(s):  
Hassan Mahmoodi ◽  
Kiyanoosh Razzaghi ◽  
Farhad Shahraki
Processes ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 464
Author(s):  
Xingren Jiang ◽  
Ning Yang ◽  
Rijie Wang

Continuous manufacturing has received increasing interest because of the advantages of intrinsic safety and enhanced mass transfer in the pharmaceutical industry. However, the difficulty for scale-up has limited the application of continuous manufacturing for a long time. Recently, the tubular flow reactor equipped with the Kenics static mixer appears to be a solution for the continuous process scale-up. Although many influence factors on the mixing performance in the Kenics static mixer have been investigated, little research has been carried out on the aspect ratio. In this study, we used the coefficient of variation as the mixing evaluation index to investigate the effect of the aspect ratio (0.2–2) on the Kenics static mixer’s mixing performance. The results indicate that a low aspect ratio helps obtain a shorter mixing time and mixer length. This study suggests that adjusting the aspect ratio of the Kenics static mixer can be a new strategy for the scale-up of a continuous process in the pharmaceutical industry.


Author(s):  
Luhong Zhang ◽  
Jiaxin Dong ◽  
Bin Jiang ◽  
Yongli Sun ◽  
Fang Zhang ◽  
...  

2016 ◽  
Vol 115 ◽  
pp. 310-324 ◽  
Author(s):  
J. Ramsay ◽  
M.J.H. Simmons ◽  
A. Ingram ◽  
E.H. Stitt

2017 ◽  
Vol 34 (5) ◽  
pp. 1328-1336 ◽  
Author(s):  
Huibo Meng ◽  
Xiuhui Jiang ◽  
Yanfang Yu ◽  
Zongyong Wang ◽  
Jianhua Wu

Author(s):  
D. Revathi ◽  
K. Saravanan

Mixing is the degree of homogeneity of two or more phases and it plays a vital role in the quality of the final product. It is conventionally carried out by mechanical agitators or by static mixers. Static mixers are a series of geometric mixing elements fixed within a pipe, which use the energy of the flow stream to create mixing between two or more fluids or to inject metered liquid into a continuous process. The objective of this work is to predict hydrodynamic aspects of the static mixer designed. The mixing performance of Komax static mixer has been determined for the blending of non-Newtonian fluid streams with identical or different rheology by using experimental study. The energy needed for mixing comes from the force created by the liquid due to turbulence and the geometry of the static mixer. Pressure drop in static mixer depend strongly on geometric arrangement of the inserts, properties of fluids to be mixed and flow conditions. Hence pressure drop studies are carried out for different flow rates of fluids with different concentrations of two non-Newtonian fluids. Starch and xanthan gum solutions are used as working fluids. It is observed from the experimental results that the pressure drop per unit length increases as the fluid flow rate increases and the nature of fluid flow varies with the velocity of the fluids.


1998 ◽  
Vol 09 (08) ◽  
pp. 1123-1128 ◽  
Author(s):  
D. Kandhai ◽  
D. J.-E. Vidal ◽  
A. G. Hoekstra ◽  
H. Hoefsloot ◽  
P. Iedema ◽  
...  

We present a comparison between the finite-element and the lattice-Boltzmann method for simulating fluid flow in a SMRX static mixer reactor. The SMRX static mixer is a piece of equipment with excellent mixing performance and it is used in highly efficient chemical reactors for viscous systems like polymers. The complex geometry of this mixer makes such 3D simulations nontrivial. An excellent agreement between the results of the two simulation methods and experimental data was found.


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