A hybrid discrete–continuous model of metastatic cancer cell migration through a remodeling extracellular matrix

AIChE Journal ◽  
2019 ◽  
Vol 65 (9) ◽  
Author(s):  
Yen T. Nguyen Edalgo ◽  
Anya L. Zornes ◽  
Ashlee N. Ford Versypt
Keyword(s):  
Extracellular Matrix ◽  
Cell Migration ◽  
Cancer Cell ◽  
Metastatic Cancer ◽  
Continuous Model ◽  
Cancer Cell Migration ◽  
Metastatic Cancer Cell

Matrix metalloproteinase targeted peptide vesicles for delivering anticancer drugs

2018 ◽  
Vol 54 (67) ◽  
pp. 9309-9312 ◽  
Author(s):  
Debmalya Bhunia ◽  
Krishnangsu Pradhan ◽  
Gaurav Das ◽  
Subhajit Ghosh ◽  
Prasenjit Mondal ◽  
...  
Keyword(s):  
Cell Migration ◽  
Matrix Metalloproteinase ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Cancer Cell ◽  
Metastatic Cancer ◽  
Cancer Cell Migration ◽  
Apoptotic Death ◽  
Metastatic Cancer Cell ◽  
3D Spheroids

A matrix metalloproteinase (MMP) targeted tetrapeptide vesicle strongly binds at a MMP9 enzymatic site and delivers an anticancer drug into cancer cells. Further, it induces superior apoptotic death and inhibits the metastatic cancer cell migration and growth of multicellular 3D spheroids.

scholarly journals Investigation of Cancer Cell Migration and Proliferation on Synthetic Extracellular Matrix Peptide Hydrogels

2020 ◽  
Vol 8 ◽  
Author(s):  
Zbigniev Balion ◽  
Emilija Sipailaite ◽  
Gabija Stasyte ◽  
Agne Vailionyte ◽  
Airina Mazetyte-Godiene ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cell Migration ◽  
Cancer Cell ◽  
Cancer Cell Migration ◽  
Cell Migration And Proliferation ◽  
Peptide Hydrogels

scholarly journals Regulation of ATP utilization during metastatic cell migration by collagen architecture

2018 ◽  
Vol 29 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Matthew R. Zanotelli ◽  
Zachary E. Goldblatt ◽  
Joseph P. Miller ◽  
Francois Bordeleau ◽  
Jiahe Li ◽  
...  
Keyword(s):  
Cell Migration ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Molecular Mechanisms ◽  
Metastatic Cancer ◽  
Three Dimensional ◽  
Migration And Invasion ◽  
Energy Regulation ◽  
Cancer Cell Migration ◽  
In Cells

Cell migration in a three-dimensional matrix requires that cells either remodel the surrounding matrix fibers and/or squeeze between the fibers to move. Matrix degradation, matrix remodeling, and changes in cell shape each require cells to expend energy. While significant research has been performed to understand the cellular and molecular mechanisms guiding metastatic migration, less is known about cellular energy regulation and utilization during three-dimensional cancer cell migration. Here we introduce the use of the genetically encoded fluorescent biomarkers, PercevalHR and pHRed, to quantitatively assess ATP, ADP, and pH levels in MDA-MB-231 metastatic cancer cells as a function of the local collagen microenvironment. We find that the use of the probe is an effective tool for exploring the thermodynamics of cancer cell migration and invasion. Specifically, we find that the ATP:ADP ratio increases in cells in denser matrices, where migration is impaired, and it decreases in cells in aligned collagen matrices, where migration is facilitated. When migration is pharmacologically inhibited, the ATP:ADP ratio decreases. Together, our data indicate that matrix architecture alters cellular energetics and that intracellular ATP:ADP ratio is related to the ability of cancer cells to effectively migrate.

scholarly journals Modeling the Mechanobiology of Cancer Cell Migration Using 3D Biomimetic Hydrogels

Gels ◽  
2021 ◽  
Vol 7 (1) ◽  
pp. 17
Author(s):  
Xabier Morales ◽  
Iván Cortés-Domínguez ◽  
Carlos Ortiz-de-Solorzano
Keyword(s):  
Extracellular Matrix ◽  
Cell Migration ◽  
Chemical Composition ◽  
Cancer Cells ◽  
Cancer Cell ◽  
State Of The Art ◽  
Three Dimensional ◽  
Cancer Cell Migration ◽  
Hydrogel Scaffolds ◽  
Metastatic Process

Understanding how cancer cells migrate, and how this migration is affected by the mechanical and chemical composition of the extracellular matrix (ECM) is critical to investigate and possibly interfere with the metastatic process, which is responsible for most cancer-related deaths. In this article we review the state of the art about the use of hydrogel-based three-dimensional (3D) scaffolds as artificial platforms to model the mechanobiology of cancer cell migration. We start by briefly reviewing the concept and composition of the extracellular matrix (ECM) and the materials commonly used to recreate the cancerous ECM. Then we summarize the most relevant knowledge about the mechanobiology of cancer cell migration that has been obtained using 3D hydrogel scaffolds, and relate those discoveries to what has been observed in the clinical management of solid tumors. Finally, we review some recent methodological developments, specifically the use of novel bioprinting techniques and microfluidics to create realistic hydrogel-based models of the cancer ECM, and some of their applications in the context of the study of cancer cell migration.

Age‐associated changes of extracellular matrix collagen impair lung cancer cell migration

2008 ◽  
Vol 23 (5) ◽  
pp. 1510-1520 ◽  
Author(s):  
Babett Bartling ◽  
Maximilian Desole ◽  
Susanne Rohrbach ◽  
Rolf‐Edgar Silber ◽  
Andreas Simm
Keyword(s):  
Lung Cancer ◽  
Extracellular Matrix ◽  
Cell Migration ◽  
Cancer Cell ◽  
Cancer Cell Migration ◽  
Lung Cancer Cell
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