scholarly journals Metastatic cancer cell attachment to endothelium is promoted by endothelial glycocalyx sialic acid degradation

AIChE Journal ◽  
2019 ◽  
Vol 65 (8) ◽  
Author(s):  
Solomon A. Mensah ◽  
Ian C. Harding ◽  
Michelle Zhang ◽  
Michael P. Jaeggli ◽  
Vladimir P. Torchilin ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Cancer Cell ◽  
Cell Attachment ◽  
Metastatic Cancer ◽  
Endothelial Glycocalyx ◽  
Acid Degradation ◽  
Metastatic Cancer Cell

scholarly journals Flow‐regulated endothelial glycocalyx determines metastatic cancer cell activity

2020 ◽  
Vol 34 (5) ◽  
pp. 6166-6184 ◽  
Author(s):  
Solomon A. Mensah ◽  
Alina A. Nersesyan ◽  
Ian C. Harding ◽  
Claire I. Lee ◽  
Xuefei Tan ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Metastatic Cancer ◽  
Cell Activity ◽  
Endothelial Glycocalyx ◽  
Metastatic Cancer Cell

scholarly journals A microfluidic platform for modeling metastatic cancer cell matrix invasion

2017 ◽  
Vol 9 (4) ◽  
pp. 045001 ◽  
Author(s):  
Laura Blaha ◽  
Chentian Zhang ◽  
Mario Cabodi ◽  
Joyce Y Wong
Keyword(s):  
Cancer Cell ◽  
Metastatic Cancer ◽  
Microfluidic Platform ◽  
Cell Matrix ◽  
Metastatic Cancer Cell

scholarly journals MYC regulation of a “poor-prognosis” metastatic cancer cell state

2010 ◽  
Vol 107 (8) ◽  
pp. 3698-3703 ◽  
Author(s):  
Anita Wolfer ◽  
Ben S. Wittner ◽  
Daniel Irimia ◽  
Richard J. Flavin ◽  
Mathieu Lupien ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Poor Prognosis ◽  
Metastatic Cancer ◽  
Cell State ◽  
Metastatic Cancer Cell

scholarly journals Photoconversion and chromatographic microfluidic system reveals differential cellular phenotypes of adhesion velocity versus persistence in shear flow

Lab on a Chip ◽  
2020 ◽  
Vol 20 (4) ◽  
pp. 806-822 ◽  
Author(s):  
Katherine G. Birmingham ◽  
Isaac E. Robinson ◽  
Erin E. Edwards ◽  
Susan N. Thomas
Keyword(s):  
Shear Flow ◽  
Cancer Cell ◽  
Cell Sorting ◽  
Metastatic Cancer ◽  
Microfluidic System ◽  
Velocity Versus ◽  
Metastatic Cancer Cell ◽  
Cellular Phenotypes ◽  
Cell Dissemination

Engineered cell sorting, photoconversion platform to interrogate mechanisms of metastatic cancer cell dissemination.

scholarly journals Riceberry rice bran protein hydrolyzed fractions induced apoptosis, senescence and G1/S cell cycle arrest in human colon cancer cell lines

2021 ◽  
Author(s):  
Vichugorn Wattayagorn ◽  
Mesayamas Kongsema ◽  
Sukuntaros Tadakittisarn ◽  
Pramote Chumnanpuen
Keyword(s):  
Colon Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Rice Bran ◽  
Metastatic Cancer ◽  
Cancer Cell Lines ◽  
Colon Cancer Cell ◽  
Colon Cancer Cell Lines ◽  
Metastatic Cancer Cell ◽  
Ht 29

Riceberry rice bran is the part of rice that has been scrubbed out during coloring process. There are various health benefits with high protein content and antioxidant ability. The hydrolyzed rice bran consists of diverse peptides that provide various bioactive properties. This work aimed to study the effect of hydrolyzed riceberry rice bran extracted on colon cancer cell lines (HT- 29 and SW- 620) compared to normal cell (PCS- 291- 010). The MTT assay result showed that our extract has less cytotoxicity on normal cell (PCS-291-010, IC50 = 6,680.00 µg/ml) compared to the colon cancer cell lines and has more effect on metastatic cancer cell line (SW-620, IC50 = 5,492.31 µg /ml) than non-metastatic cancer cell line (HT-29, IC50 =6,040.76 µg/ml). According to the DNA fragmentation pattern analysis, the ladder pattern indicated that the rice bran extract can induce the apoptosis process in SW-620 cell line. Confirmed the pattern of apoptotic cell by AO/PI double stain test and quantified apoptotic cells by Annexin V. For the cell senescence analysis, SA-β-gal staining technique was performed at 24 h after treatments, HT-29 reached maximum senescence rate at 85.74% while SW-620 had only 17.23% of senescence. And a result of cell cycle analysis, HT-29 were decreased the number of cells in S, M/G2 phase, and increased the number of cells in G0/G1 phase. Furthermore > 50 kDa peptide fraction separated from HRBE has a potent anti-cancer cells (SW-620, IC50 = 4,908 µg/ml). In conclusion, the hydrolyzed riceberry rice bran extract can inhibit colon cancer cell lines with less effect on normal cell. The extracts could induce apoptosis process in metastatic cancer cell and induce senescence process in non-metastatic cancer cell. This observed information will be useful and applicable for medical research and colon cancer treatment in the future.

Microfluidic Devices in Capturing Circulating Metastatic Cancer Cell Clusters

2021 ◽  
pp. 261-278
Author(s):  
Sandeep Arora ◽  
Ajmer Singh Grewal ◽  
Neelam Sharma ◽  
Sukhbir Singh
Keyword(s):  
Cancer Cell ◽  
Metastatic Cancer ◽  
Microfluidic Devices ◽  
Cell Clusters ◽  
Metastatic Cancer Cell
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