Engineering red-blood-cell-membrane-coated nanoparticles for broad biomedical applications

AIChE Journal ◽  
2015 ◽  
Vol 61 (3) ◽  
pp. 738-746 ◽  
Author(s):  
Weiwei Gao ◽  
Liangfang Zhang
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Biomedical Applications ◽  
Red Blood Cell Membrane ◽  
Coated Nanoparticles

scholarly journals Size Dependency of Circulation and Biodistribution of Biomimetic Nanoparticles: Red Blood Cell Membrane-Coated Nanoparticles

Cells ◽  
2019 ◽  
Vol 8 (8) ◽  
pp. 881 ◽  
Author(s):  
Haichun Li ◽  
Kai Jin ◽  
Man Luo ◽  
Xuejun Wang ◽  
Xiaowen Zhu ◽  
...  
Keyword(s):  
Particle Size ◽  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Biomedical Applications ◽  
Immune Modulation ◽  
Red Blood Cell Membrane ◽  
Coated Nanoparticles ◽  
Biomimetic Nanoparticles

Recently, biomimetic nanoparticles, especially cell membrane-cloaked nanoparticles, have attracted increasing attention in biomedical applications, including antitumor therapy, detoxification, and immune modulation, by imitating the structure and the function of biological systems such as long circulation life in the blood. However, the circulation time of cell membrane-cloaked nanoparticles is far less than that of the original cells, greatly limiting their biomedical applications, while the underlying reasons are seldom demonstrated. In this study, the influence of particle size on the circulation and the biodistribution of red blood cell membrane-coated nanoparticles (RBC-NPs) as model biomimetic nanoparticles were investigated. Differently sized RBC-NPs (80, 120, 160, and 200 nm) were prepared by fusing RBC membranes on poly(lactic-co-glycolic acid) nanoparticles. It was shown that the particle size did not change the cellular uptake of these biomimetic nanoparticles by macrophage cells in vitro and their immunogenic responses in vivo. However, their circulation life in vivo decreased with the particle size, while their accumulation in the liver increased with the particle size, which might be related to their size-dependent filtration through hepatic sinusoids. These findings will provide experimental evidence for the design and the optimization of biomimetic nanoparticles.

Fabrication and characterization of a 3D bioprinted nanoparticle-hydrogel hybrid device for biomimetic detoxification

Nanoscale ◽  
2017 ◽  
Vol 9 (38) ◽  
pp. 14506-14511 ◽  
Author(s):  
Maggie S. Chen ◽  
Yue Zhang ◽  
Liangfang Zhang
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Hybrid Device ◽  
Red Blood Cell Membrane ◽  
Coated Nanoparticles ◽  
Fabrication And Characterization

We report a 3D-bioprinted micro/nanodevice that encapsulates red blood cell membrane-coated nanoparticles with inner channels for biodetoxification.

scholarly journals Red Blood Cell Membrane Processing for Biomedical Applications

2019 ◽  
Vol 10 ◽  
Author(s):  
Luigia Rossi ◽  
Alessandra Fraternale ◽  
Marzia Bianchi ◽  
Mauro Magnani
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Biomedical Applications ◽  
Red Blood Cell Membrane ◽  
Membrane Processing

scholarly journals Red Blood Cell Membrane-Camouflaged Tedizolid Phosphate-Loaded PLGA Nanoparticles for Bacterial-Infection Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 99
Author(s):  
Xinyi Wu ◽  
Yichen Li ◽  
Faisal Raza ◽  
Xuerui Wang ◽  
Shulei Zhang ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Cell Membrane ◽  
Blood Cell ◽  
Sustained Release ◽  
Delivery System ◽  
Red Blood Cell ◽  
Multiple Drug Resistance ◽  
Plga Nanoparticles ◽  
Multiple Drug ◽  
Red Blood Cell Membrane

Multiple drug resistance (MDR) in bacterial infections is developed with the abuse of antibiotics, posing a severe threat to global health. Tedizolid phosphate (TR-701) is an efficient prodrug of tedizolid (TR-700) against gram-positive bacteria, including methicillin-sensitive staphylococcus aureus (MSSA) and methicillin-resistant staphylococcus aureus (MRSA). Herein, a novel drug delivery system: Red blood cell membrane (RBCM) coated TR-701-loaded polylactic acid-glycolic acid copolymer (PLGA) nanoparticles (RBCM-PLGA-TR-701NPs, RPTR-701Ns) was proposed. The RPTR-701Ns possessed a double-layer core-shell structure with 192.50 ± 5.85 nm in size, an average encapsulation efficiency of 36.63% and a 48 h-sustained release in vitro. Superior bio-compatibility was confirmed with red blood cells (RBCs) and HEK 293 cells. Due to the RBCM coating, RPTR-701Ns on one hand significantly reduced phagocytosis by RAW 264.7 cells as compared to PTR-701Ns, showing an immune escape effect. On the other hand, RPTR-701Ns had an advanced exotoxins neutralization ability, which helped reduce the damage of MRSA exotoxins to RBCs by 17.13%. Furthermore, excellent in vivo bacteria elimination and promoted wound healing were observed of RPTR-701Ns with a MRSA-infected mice model without causing toxicity. In summary, the novel delivery system provides a synergistic antibacterial treatment of both sustained release and bacterial toxins absorption, facilitating the incorporation of TR-701 into modern nanotechnology.

scholarly journals Direct Measurement of the Area Expansion and Shear Moduli of the Human Red Blood Cell Membrane Skeleton

2001 ◽  
Vol 81 (1) ◽  
pp. 43-56 ◽  
Author(s):  
Guillaume Lenormand ◽  
Sylvie Hénon ◽  
Alain Richert ◽  
Jacqueline Siméon ◽  
François Gallet
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Direct Measurement ◽  
Red Blood Cell ◽  
Membrane Skeleton ◽  
Shear Moduli ◽  
Red Blood Cell Membrane ◽  
Area Expansion

Interaction of Different Extracts ofPrimula heterochromaStapf. with Red Blood Cell Membrane Lipids and Proteins: Antioxidant and Antihemolytic Effects

2012 ◽  
Vol 9 (4) ◽  
pp. 285-292 ◽  
Author(s):  
Seyed Mohammad Nabavi ◽  
Seyed Fazel Nabavi ◽  
William N. Setzer ◽  
Heshmatollah Alinezhad ◽  
Mahboobeh Zare ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Membrane Lipids ◽  
Red Blood Cell Membrane
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