Experimental characterization and modeling of twin-screw extruder elements for pharmaceutical hot melt extrusion

AIChE Journal ◽  
2013 ◽  
Vol 59 (11) ◽  
pp. 4440-4450 ◽  
Author(s):  
Andreas Eitzlmayr ◽  
Johannes Khinast ◽  
Gudrun Hörl ◽  
Gerold Koscher ◽  
Gavin Reynolds ◽  
...  
Keyword(s):  
Hot Melt Extrusion ◽  
Twin Screw Extruder ◽  
Experimental Characterization ◽  
Melt Extrusion ◽  
Screw Extruder ◽  
Twin Screw ◽  
Hot Melt

Hot-Melt Granulation in a Twin Screw Extruder: Effects of Processing on Formulations with Caffeine and Ibuprofen

2013 ◽  
Vol 102 (12) ◽  
pp. 4330-4336 ◽  
Author(s):  
Sharleen Weatherley ◽  
B.O. MU ◽  
Michael R. Thompson ◽  
Paul J. Sheskey ◽  
Kevin P. O'Donnell
Keyword(s):  
Twin Screw Extruder ◽  
Screw Extruder ◽  
Twin Screw ◽  
Hot Melt Granulation ◽  
Hot Melt ◽  
Melt Granulation

scholarly journals IMPROVING SOLUBILITY AND DISSOLUTION OF A NATURAL PRODUCT APIGENIN VIA PREPARATION OF SOLID DISPERSION BY HOT MELT EXTRUSION

2021 ◽  
pp. 47-52
Author(s):  
SOFI N. STIANI ◽  
TAOFIK RUSDIANA ◽  
ANAS SUBARNAS
Keyword(s):  
Solid Dispersion ◽  
Water Solubility ◽  
Practical Method ◽  
Hot Melt Extrusion ◽  
Raw Material ◽  
Melt Extrusion ◽  
Scanning Calorimetry ◽  
Twin Screw ◽  
Hot Melt

Objective: Hot Melt Extrusion (HME) is one of the techniques for preparing a solid dispersion hydrophilic excipient known as a no solvents practical method to increase the solubility of drugs. Apigenin (APG) has properties that thermal stable with melting point 345-350 °C but very low solubility in the water around 1,35 µg/ml. The polymer is stable in the HME method are Soluplus and Kollidon VA 64. The study aims to optimize the kind of polymer in HME formulae to improve the solubility and dissolution rate of apigenin by solid dispersion using hot-melt extrusion. Methods: Apigenin 10–50% w/w and Kollidon®VA 64 or Soluplus® and combination of Kollidon®VA 64 and Soluplus® were mixed, and the resulting blends extruded using a twin-screw extruder (Teach-Line ZK25T). Characterization of apigenin extrudates conducted using scanning electron microscopy, thermogravimetric analysis, differential scanning calorimetry, Fourier transform infrared spectroscopy, powder X-ray diffractometry, and dissolution. Results: Solubility studies presented enhancement in apigenin of 10%/Soluplus®90%; 10% w/w apigenin/Kollidon®VA 64 (90%); and 33,3% w/w apigenin/Kollidon®VA 64 33,3% mix Soluplus® 33,3% increased more than 18,25; 16,18-and 8,52-fold in water, respectively. Furthermore dissolution studies showed enhancement in apigenin percent release of 10%/Soluplus®90%; 10% w/w apigenin/Kollidon®VA 64 90%; and 33,3% w/w apigenin/Kollidon®VA 64 33,3% mix Soluplus® 33,3% tablet apigenin HME up to 34,29%; 69,75% and 30,69%, respectively. Conclusion: The formulation of 10% w/w Apigenin and 90% Soluplus® using hot-melt extrusion able to increase water solubility approximately 18,25-fold than raw material apigenin.

scholarly journals COMPRITOL® 888 LIPID MATRIX VIA TWIN SCREW EXTRUDER

2019 ◽  
Vol 11 (1) ◽  
pp. 261
Author(s):  
Abishek Wadhwa ◽  
Vashish Mathura ◽  
Mahalaxmi Rathnanand ◽  
Anup Naha ◽  
Shaila Angela Lewis
Keyword(s):  
Hot Melt Extrusion ◽  
Extrusion Process ◽  
In Vitro Dissolution ◽  
Fusion Method ◽  
Melt Extrusion ◽  
Dissolution Studies ◽  
Twin Screw ◽  
Model Drug ◽  
Hot Melt

Objective: The objective of this research was to explore the potential of Hot Melt Extrusion (HME) technique by using theophylline as the model drug to produce sustained release tablets utilizing Compritol®888 ATO as the retarding material and to study the influence of lipid: excipient ratio, excipient type as well as the processing conditions of the extruder on the release profile.Methods: The tablets prepared using hot fusion method was compared to the ones concocted by the HME technology. During the HME process, a powder mixture of moisture-free drug, lipid, and other adjuncts was introduced into the extruder and liquefied inside the barrel of the extruder. The in vitro dissolution studies of the formulations were carried out in pH 7.2 buffer using USP Apparatus 2. The extrudates were characterized via differential scanning calorimetry.Results: Comparing the two methods of processing, it was observed by the dissolution studies using phosphate buffer pH 7.2, that the tablets prepared by Hot Melt Extrusion method had a higher extent of release where all 3 formulations crossed 80% at the 8-hour mark, whereas the tablets prepared by hot fusion method did not show such consistency.Conclusion: This study demonstrated the fact that Compritol®888 ATO is a suitable waxy material that can be used as a matrix-forming agent to control the release of theophylline using the Hot Melt Extrusion process.

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