Optimal design of simulated moving-bed processes under flow rate uncertainty

AIChE Journal ◽  
2007 ◽  
Vol 53 (10) ◽  
pp. 2630-2642 ◽  
Author(s):  
José P. B. Mota ◽  
João M. M. Araújo ◽  
Rui. C. R. Rodrigues
Keyword(s):  
Optimal Design ◽  
Flow Rate ◽  
Simulated Moving Bed ◽  
Moving Bed

Optimal design and operation of a certain class of asynchronous simulated moving bed processes

2006 ◽  
Vol 1132 (1-2) ◽  
pp. 76-89 ◽  
Author(s):  
João M.M. Araújo ◽  
Rui.C.R. Rodrigues ◽  
José P.B. Mota
Keyword(s):  
Optimal Design ◽  
Simulated Moving Bed ◽  
Moving Bed

Optimal Design of a Size-Exclusion Tandem Simulated Moving Bed for Insulin Purification

2003 ◽  
Vol 42 (9) ◽  
pp. 1977-1993 ◽  
Author(s):  
Sungyong Mun ◽  
Yi Xie ◽  
Jin-Hyun Kim ◽  
Nien-Hwa Linda Wang
Keyword(s):  
Optimal Design ◽  
Size Exclusion ◽  
Simulated Moving Bed ◽  
Moving Bed

Simulated Moving Bed Purification for Flavonoids from Tartary Buckwheat Shell

2020 ◽  
Vol 58 (4) ◽  
pp. 362-372
Author(s):  
Liangyu Li ◽  
Wanxia Liu ◽  
Dawei Song ◽  
Chaoyang Li ◽  
Pengyu Jia ◽  
...  
Keyword(s):  
Flow Rate ◽  
Antioxidant Properties ◽  
Tartary Buckwheat ◽  
Preparative Chromatography ◽  
Simulated Moving Bed ◽  
Feed Concentration ◽  
Adsorption Parameters ◽  
Moving Bed ◽  
Ic50 Values ◽  
Dpph Scavenging

Abstract Tartary buckwheat shell is an important by-product of Tartary buckwheat production. Previous studies shown that Tartary buckwheat shells are rich in flavonoids, which are responsible for their antioxidant properties. Due to lack of advanced separation technologies, the purification for Tartary buckwheat shell is still in the laboratory scale, and could not realize the industrialization production. According to the results of static adsorption experiment, AB-8 resin was selected for Tartary buckwheat shell flavonoids (TBSF) adsorption. The adsorption isotherm, resin adsorption thermodynamic and dynamic adsorption parameters were studied. And the adsorption of AB-8 resin for TBSF was determined as an endothermic process. Results of preparative chromatography experiment showed that TBSF could be efficiently purified by AB-8 resin. And the optimal parameters were: feed concentration 25 mg/mL, desorption flow rate 2.5 mL/min. Under these conditions, the TBSF were separated effectively. Results of liquid chromatography-mass spectrometer (LC-MS) indicated that there were seven kinds of flavonoids in Tartary buckwheat shell, which were mainly from the 40 and 60% of ethanol elution. Simulated moving bed (SMB) was applied for TBSF purification the first time in this study. The optimal conditions of SMB were as following: adsorption zone flow rate 7.0 mL/min, contaminant removal zone flow rate 17.9 mL/min, product elution zone flow rate 22.3 mL/min, regeneration zone flow rate 21.5 mL/min, water washing zone flow rate 27.5 mL/min, switching time 1260 S, and the purity and yield of TBSF was 90 ± 0.22% and 85 ± 0.28%, respectively. The IC50 values of α-glucosidase inhibition activities and DPPH scavenging activity of the purified TBSF were 57.09 ± 0.15 and 7.92 ± 0.23 μg/mL, respectively. The constituents of TBSF showed higher α-glucosidase inhibition activities and antioxidant than raw TBSF and rutin. The results suggest that SMB is a proper method for industrial production of TBSF, and SMB could be applied for other natural products purification.

Effects of flow-rate ratio on startup and cyclic steady-state behaviors of simulated moving bed under linear conditions

2008 ◽  
Vol 62 (1) ◽  
pp. 148-159 ◽  
Author(s):  
Youn-Sang Bae ◽  
Kyung-Min Kim ◽  
Jong-Ho Moon ◽  
Sang-Hoon Byeon ◽  
Ik-Sung Ahn ◽  
...  
Keyword(s):  
Steady State ◽  
Flow Rate ◽  
Rate Ratio ◽  
Flow Rate Ratio ◽  
Simulated Moving Bed ◽  
Moving Bed
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