Optimal design of an integrated fermentation process for lactic acid production

AIChE Journal ◽  
2007 ◽  
Vol 53 (2) ◽  
pp. 449-459 ◽  
Author(s):  
Hsun-Tung Lin ◽  
Feng-Sheng Wang
Keyword(s):  
Lactic Acid ◽  
Optimal Design ◽  
Acid Production ◽  
Fermentation Process ◽  
Lactic Acid Production

scholarly journals Dynamic Simulation of Continuous Mixed Sugars Fermentation with Increasing Cell Retention Time for Lactic Acid Production using Enterococcus mundtii QU 25

2020 ◽  
Author(s):  
Ying Wang ◽  
Ka-Lai Chan ◽  
Mohamed Ali Abdel-Rahman ◽  
Kenji Sonomoto ◽  
Shao-Yuan Leu
Keyword(s):  
Lactic Acid ◽  
Retention Time ◽  
Acid Production ◽  
Fermentation Process ◽  
Lactic Acid Production ◽  
Critical Role ◽  
Cell Retention ◽  
Mixed Sugars ◽  
Enterococcus Mundtii ◽  
Mixed Sugar

Abstract Background: Simultaneous and effective conversion of both pentose and hexoses in fermentation is a critical and challenging task toward the lignocellulosic economy. This study aims to investigate the feasibility of an innovative co-fermentation process featured with cell recycle unit (CF/CR) for mixed sugar utilization. A l-lactic acid producing strain Enterococcus mundtii QU 25 was applied in the continuous fermentation process to utilize the mixed sugar at different productivities over the changes of flowing conditions. Structured numerical platform were constructed with the experiments to optimize the biological process and clarify the cell metabolisms through kinetics analysis. The structured model, kinetic parameters, and achievement of the fermentation strategy shall provide new insights towards whole sugar fermentation via real-time monitoring for process control and optimization.Results: Significant carbon catabolite repression of co-fermentation using glucose/xylose mixture was overcome by replacing glucose with cellobiose, of which the consumption ratio of hexose to pentose was improved dramatically from 10.4:1 to 2.17:1. An outstanding product concentration of 65.15 g·L -1 and productivity of 13.03 g·L -1 ·h -1 were achieved with 50 g·L -1 cellobiose and 30 g·L -1 xylose, at an optimized dilution rate of 0.2 h -1 with gradually increased cell retention time. Among the total lactic acid production, xylose contributed to more than 34% of the mixed sugars, which was close to the related contents in agricultural residuals. The model successfully simulated the transition of sugar consumption, cell growth, and lactic acid production among the batch, continuous process, and CF/CR system.Conclusion: Cell retention time played a critical role in balancing pentose and hexose consumption, cell decay, and lactic acid production in the CF/CR process. With the increase of cell concentration, consumption of mixed sugars increased with the productivity of final products, hence the impacts of substrate inhibiting reduced. With the validated parameters, the model showed highest accuracy simulating the CF/CR process, of which significantly longer cell retention times over hydraulic retention time were tested.

scholarly journals Betaine Improves Polymer-Grade D-Lactic Acid Production by Sporolactobacillus inulinus Using Ammonia as Green Neutralizer

2017 ◽  
Vol 66 (2) ◽  
pp. 273-276 ◽  
Author(s):  
Guoping Lv ◽  
Chengchuan Che ◽  
Li Li ◽  
Shujing Xu ◽  
Wanyi Guan ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Acid Production ◽  
Fermentation Process ◽  
Specific Activity ◽  
Lactic Acid Production ◽  
Optical Purity ◽  
Ammonium Ion ◽  
High Concentration ◽  
Acid Fermentation ◽  
High Optical Purity

The traditional CaCO3-based fermentation process generates huge amount of insoluble waste. To solve this problem, we have developed an efficient and green D-lactic acid fermentation process by using ammonia as neutralizer. The 106.7 g/l of D-lactic acid production and 0.89 g/g of consumed sugar were obtained by Sporolactobacillus inulinus CASD with a high optical purity of 99.7% by adding 100 mg/l betaine in the simple batch fermentation. The addition of betaine was experimentally proven to protect cell at high concentration of ammonium ion, increase the D-lactate dehydrogenase specific activity and thus promote the production of D-lactic acid.

Improving cell yield and lactic acid production of Lactococcus lactis ssp. cremoris by a novel submerged membrane fermentation process

2012 ◽  
Vol 403-404 ◽  
pp. 179-187 ◽  
Author(s):  
Lata Ramchandran ◽  
Peter Sanciolo ◽  
Todor Vasiljevic ◽  
Malcolm Broome ◽  
Ian Powell ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Lactococcus Lactis ◽  
Acid Production ◽  
Fermentation Process ◽  
Lactic Acid Production ◽  
Cell Yield
Sign in / Sign up

Export Citation Format

Share Document