Particle migration in the rotating flow between co-axial disks

AIChE Journal ◽  
2006 ◽  
Vol 52 (6) ◽  
pp. 2039-2045 ◽  
Author(s):  
Adetola A. Abatan ◽  
Joseph J. McCarthy ◽  
Watson L. Vargas
Keyword(s):  
Particle Migration ◽  
Rotating Flow

ASPECTS OF HETEROGENOUS AND HOMOGENOUS REACTIONS ON HYDROMAGNETIC OSCILLATORY ROTATING FLOW IN POROUS MEDIUM

2020 ◽  
Vol 23 (9) ◽  
pp. 837-850
Author(s):  
Zaheer Abbas ◽  
Amar Rauf ◽  
Sabir Ali Shehzad
Keyword(s):  
Porous Medium ◽  
Rotating Flow

scholarly journals Surface charge modulation of rifampicin-loaded PLA nanoparticles to improve antibiotic delivery in Staphylococcus aureus biofilms

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
David Da Costa ◽  
Chloé Exbrayat-Héritier ◽  
Basile Rambaud ◽  
Simon Megy ◽  
Raphaël Terreux ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Surface Charge ◽  
Treatment Efficacy ◽  
Particle Migration ◽  
Bacterial Biofilm ◽  
Poly Lactic Acid ◽  
Retention Capacity ◽  
The Impact ◽  
Positively Charged ◽  
Antibiotic Delivery

Abstract Background After the golden age of antibiotic discovery, bacterial infections still represent a major challenge for public health worldwide. The biofilm mode of growth is mostly responsible for chronic infections that current therapeutics fail to cure and it is well-established that novel strategies must be investigated. Particulate drug delivery systems are considered as a promising strategy to face issues related to antibiotic treatments in a biofilm context. Particularly, poly-lactic acid (PLA) nanoparticles present a great interest due to their ability to migrate into biofilms thanks to their submicronic size. However, questions still remain unresolved about their mode of action in biofilms depending on their surface properties. In the current study, we have investigated the impact of their surface charge, firstly on their behavior within a bacterial biofilm, and secondly on the antibiotic delivery and the treatment efficacy. Results Rifampicin-loaded PLA nanoparticles were synthetized by nanoprecipitation and characterized. A high and superficial loading of rifampicin, confirmed by an in silico simulation, enabled to deliver effective antibiotic doses with a two-phase release, appropriate for biofilm-associated treatments. These nanoparticles were functionalized with poly-l-lysine, a cationic peptide, by surface coating inducing charge reversal without altering the other physicochemical properties of these particles. Positively charged nanoparticles were able to interact stronger than negative ones with Staphylococcus aureus, under planktonic and biofilm modes of growth, leading to a slowed particle migration in the biofilm thickness and to an improved retention of these cationic particles in biofilms. While rifampicin was totally ineffective in biofilms after washing, the increased retention capacity of poly-l-lysine-coated rifampicin-loaded PLA nanoparticles has been associated with a better antibiotic efficacy than uncoated negatively charged ones. Conclusions Correlating the carrier retention capacity in biofilms with the treatment efficacy, positively charged rifampicin-loaded PLA nanoparticles are therefore proposed as an adapted and promising approach to improve antibiotic delivery in S. aureus biofilms.

scholarly journals Combined electrokinetic and shear flows control colloidal particle distribution across microchannel cross-sections

Soft Matter ◽  
2021 ◽  
Author(s):  
Varun Lochab ◽  
Shaurya Prakash
Keyword(s):  
Shear Flow ◽  
Cross Sections ◽  
Lift Force ◽  
Shear Flows ◽  
Colloidal Particle ◽  
Particle Distribution ◽  
Particle Migration ◽  
Flow Parameters

We quantify and investigate the effects of flow parameters on the extent of colloidal particle migration and the corresponding electrophoresis-induced lift force under combined electrokinetic and shear flow.

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