scholarly journals Effect of TU‐100 on Peyer's patches in a bacterial translocation rat model

2021 ◽  
Author(s):  
Chie Takasu ◽  
Katsuki Miyazaki ◽  
Kozo Yoshikawa ◽  
Masaaki Nishi ◽  
Takuya Tokunaga ◽  
...  
Keyword(s):  
Bacterial Translocation ◽  
Rat Model ◽  
Peyer's Patches ◽  
Peyer’S Patches

scholarly journals A rat model of mild intestinal inflammation induced byStaphylococcus aureusenterotoxin B

2010 ◽  
Vol 69 (3) ◽  
pp. 447-453 ◽  
Author(s):  
Anna Pérez-Bosque ◽  
Miquel Moretó
Keyword(s):  
T Lymphocytes ◽  
Inflammatory Cytokines ◽  
Rat Model ◽  
Plasma Proteins ◽  
Intestinal Inflammation ◽  
Killer Cell ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Activated T Lymphocytes ◽  
Pro Inflammatory Cytokines

The epithelial barrier of the intestine and the gut-associated lymphoid tissue (GALT) protects the host against luminal pathogenic micro-organisms. This is important at weaning, when animals are exposed to infectious agents and stresses. We have developed a rat model of intestinal inflammation post weaning, based on the systemic administration ofStaphylococcus aureusenterotoxin B (SEB). Since the inflammatory response obtained is mild, the food intake pattern is not affected, which makes this model useful for studies of nutritional therapies for intestinal inflammatory disease. SEB increased T-lymphocytes in Peyer's patches and the number of activated T-lymphocytes in mesenteric lymph nodes (organized GALT). In the lamina propria, SEB increased activated T-lymphocytes as well as cytotoxic and natural killer-cell populations of the diffuse GALT. It also increased pro-inflammatory cytokines and inflammatory mediators in both Peyer's patches and mucosa. Rats given SEB had higher paracellular permeability to macromolecules, which was associated with a reduction in epithelial tightness. This model was used to examine whether dietary supplementation with spray-dried animal plasma proteins affects intestinal inflammation. Results showed that dietary plasma proteins can attenuate the mucosal immune response in both organized and diffuse GALT and that these effects are mediated by a reduction in the production of pro-inflammatory cytokines.

scholarly journals Mucosal immunity–mediated modulation of the gut microbiome by oral delivery of probiotics into Peyer’s patches

2021 ◽  
Vol 7 (20) ◽  
pp. eabf0677
Author(s):  
Sisi Lin ◽  
Subhajit Mukherjee ◽  
Juanjuan Li ◽  
Weiliang Hou ◽  
Chao Pan ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Bacterial Translocation ◽  
Mucosal Immunity ◽  
Oral Delivery ◽  
Immunoglobulin A ◽  
Intestinal Barrier ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
External Threats ◽  
Microfold Cells

Methods capable of maintaining gut microbiota homeostasis to prevent bacterial translocation and infection under external threats are critical for multiple facets of human health but have been rarely reported. Here, we describe the elicitation of mucosal immunity to modulate the gut microbiota by oral delivery of living probiotics into Peyer’s patches. Probiotics are individually camouflaged within a yeast membrane, on which the embedded β-glucan can facilitate the phagocytosis of microfold cells that locate in the intestinal epithelium. The delivery of probiotics into lymphoid follicles after oral ingestion promotes robust mucosal immune responses and notably upgrades the production of secretory immunoglobulin A. The provoked immunity positively regulates the gut microflora, which, in turn, retains gut homeostasis and provides defense against environmental attacks. In two murine models of gut barrier impairment, oral administration with camouflaged probiotics effectively prevents the breakdown of intestinal barrier and evidences limited bacterial translocation and systemic inflammation.

Post-mortem Peyer’s patches: Their potential application in forensic medicine

2009 ◽  
Vol 00 (00) ◽  
pp. 090513010017019-7
Author(s):  
Biagio Solarino ◽  
Giancarlo Di Vella ◽  
Thea Magrone ◽  
Felicita Jirillo ◽  
Angela Tafaro ◽  
...  
Keyword(s):  
Forensic Medicine ◽  
Potential Application ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Post Mortem

scholarly journals Fibroblastic reticular cell lineage convergence in Peyer’s patches governs intestinal immunity

2021 ◽  
Vol 22 (4) ◽  
pp. 510-519
Author(s):  
Alejandro Prados ◽  
Lucas Onder ◽  
Hung-Wei Cheng ◽  
Urs Mörbe ◽  
Mechthild Lütge ◽  
...  
Keyword(s):  
Cell Lineage ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Reticular Cell ◽  
Intestinal Immunity ◽  
Fibroblastic Reticular Cell

scholarly journals HMGB1 promotes CXCL12‐dependent egress of murine B cells from Peyer's patches in homeostasis

2021 ◽  
Author(s):  
Lorenzo Spagnuolo ◽  
Viola Puddinu ◽  
Noémie Boss ◽  
Thibaud Spinetti ◽  
Anne Oberson ◽  
...  
Keyword(s):  
B Cells ◽  
Peyer's Patches ◽  
Peyer’S Patches

scholarly journals Whipple’s Disease Affecting Ileal Peyer’s Patches: The First Case Report

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Sabah Sid’Amar ◽  
Giacomo Puppa
Keyword(s):  
Lymphoid Tissue ◽  
Diagnostic Yield ◽  
Clinical Investigation ◽  
Periodic Acid ◽  
Disease Diagnosis ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Whipple’S Disease ◽  
Whipple's Disease ◽  
First Case

Whipple’s disease is a rare chronic systemic bacterial infectious disease which can affect multiple organs, with a wide clinical spectrum encompassing many symptoms presenting in various forms and combinations. In the cases where the gastrointestinal tract is implicated, the more frequent localizations involve the small bowel, especially the duodenum. A case of a 67-year-old man who underwent clinical investigation after presenting with a progressive weight loss and showing a hypercapting right paracoeliac adenopathy at PET-CT scan is reported herein. A gastroscopy and a colonoscopy were done. The biopsies of the endoscopically normal ileal mucosa encompassed some submucosal Peyer’s patches. Histological examination of this lymphoid tissue revealed several foamy macrophages which turned out positive on periodic acid-Schiff special staining. Polymerase chain reaction of the microdissected lymph follicles allowed for confirming Whipple’s disease diagnosis. A targeted antibiotic treatment administrated to the patient led to a rapid clinical improvement. This finding of a previously unreported localization of infected macrophages in Whipple’s disease suggests that sampling the organized mucosal-submucosal lymphoid tissue may increase the diagnostic yield in endoscopic biopsies.

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