scholarly journals Precision medicine based on surgical oncology in the era of genome-scale analysis and genome editing technology

2018 ◽  
Vol 2 (2) ◽  
pp. 106-115 ◽  
Author(s):  
Shinji Tanaka
Keyword(s):  
Precision Medicine ◽  
Genome Editing ◽  
Surgical Oncology ◽  
Scale Analysis ◽  
Genome Scale

Integrated Genome-Scale Analysis and Northern Blot Detection of Retrotransposon siRNAs Across Plant Species

2020 ◽  
pp. 387-411
Author(s):  
Marcel Böhrer ◽  
Bart Rymen ◽  
Christophe Himber ◽  
Aude Gerbaud ◽  
David Pflieger ◽  
...  
Keyword(s):  
Plant Species ◽  
Northern Blot ◽  
Scale Analysis ◽  
Genome Scale

scholarly journals Genome-scale analysis of evolutionary rate and selection in a fast-expanding Spanish cluster of HIV-1 subtype F1

2018 ◽  
Vol 66 ◽  
pp. 43-47 ◽  
Author(s):  
Juan Á. Patiño-Galindo ◽  
Francisco Domínguez ◽  
María T. Cuevas ◽  
Elena Delgado ◽  
Mónica Sánchez ◽  
...  
Keyword(s):  
Evolutionary Rate ◽  
Scale Analysis ◽  
Genome Scale ◽  
Hiv 1

Identification and validation of tumor environment phenotypes in lung adenocarcinoma by integrative genome-scale analysis

2020 ◽  
Vol 69 (7) ◽  
pp. 1293-1305
Author(s):  
Guoshu Bi ◽  
Zhencong Chen ◽  
Xiaodong Yang ◽  
Jiaqi Liang ◽  
Zhengyang Hu ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Scale Analysis ◽  
Tumor Environment ◽  
Genome Scale

scholarly journals Next Generation Precision Medicine: CRISPR-mediated Genome Editing for the Treatment of Neurodegenerative Disorders

2019 ◽  
Vol 14 (4) ◽  
pp. 608-641 ◽  
Author(s):  
Sudhanshu P. Raikwar ◽  
Nidhi S. Kikkeri ◽  
Ragha Sakuru ◽  
Daniyal Saeed ◽  
Haris Zahoor ◽  
...  
Keyword(s):  
Precision Medicine ◽  
Genome Editing ◽  
Neurodegenerative Disorders ◽  
Next Generation

scholarly journals Genome-Scale Analysis Identifies Novel Transcript-Variants in Esophageal Adenocarcinoma

2020 ◽  
Vol 10 (3) ◽  
pp. 652-654.e17
Author(s):  
B.P.D. Purkayastha ◽  
E.R. Chan ◽  
D. Ravillah ◽  
L. Ravi ◽  
R. Gupta ◽  
...  
Keyword(s):  
Esophageal Adenocarcinoma ◽  
Scale Analysis ◽  
Novel Transcript ◽  
Transcript Variants ◽  
Genome Scale

scholarly journals Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Joana Ferreira da Silva ◽  
Sejla Salic ◽  
Marc Wiedner ◽  
Paul Datlinger ◽  
Patrick Essletzbichler ◽  
...  
Keyword(s):  
Genome Editing ◽  
Large Scale ◽  
Dependent Manner ◽  
Dna Double Strand Breaks ◽  
End Joining ◽  
Knock Out ◽  
Genetic Ablation ◽  
Alternative End Joining ◽  
Non Homologous End Joining ◽  
Genome Scale

Abstract The mutagenic repair of Cas9 generated breaks is thought to predominantly rely on non-homologous end-joining (NHEJ), leading to insertions and deletions within DNA that culminate in gene knock-out (KO). In this study, by taking focused as well as genome-wide approaches, we show that this pathway is dispensable for the repair of such lesions. Genetic ablation of NHEJ is fully compensated for by alternative end joining (alt-EJ), in a POLQ-dependent manner, resulting in a distinct repair signature with larger deletions that may be exploited for large-scale genome editing. Moreover, we show that cells deficient for both NHEJ and alt-EJ were still able to repair CRISPR-mediated DNA double-strand breaks, highlighting how little is yet known about the mechanisms of CRISPR-based genome editing.

scholarly journals Genome-scale analysis of replication timing: from bench to bioinformatics

2011 ◽  
Vol 6 (6) ◽  
pp. 870-895 ◽  
Author(s):  
Tyrone Ryba ◽  
Dana Battaglia ◽  
Benjamin D Pope ◽  
Ichiro Hiratani ◽  
David M Gilbert
Keyword(s):  
Replication Timing ◽  
Scale Analysis ◽  
Genome Scale
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