scholarly journals Safety and efficacy of directly‐acting antiviral therapy for chronic hepatitis C virus in elderly people

2021 ◽  
Author(s):  
Adriano De Santis ◽  
Daniela Maggi ◽  
Federica Lubrano Lobianco
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiviral Therapy ◽  
Elderly People ◽  
Chronic Hepatitis C ◽  
Safety And Efficacy ◽  
Chronic Hepatitis C Virus

scholarly journals Clinical and epidemiological characteristics of chronic hepatitis C virus infection in elderly patients

2014 ◽  
Vol 67 (suppl. 2) ◽  
pp. 39-43
Author(s):  
Tomislav Preveden ◽  
Milos Vujanovic ◽  
Maja Ruzic ◽  
Nadica Kovacevic ◽  
Radoslava Doder ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Antiviral Therapy ◽  
Elderly People ◽  
Chronic Hepatitis C ◽  
Hepatitis C Virus Infection ◽  
Chronic Hepatitis C Virus ◽  
Epidemiological Characteristics

Introduction. Chronic hepatitis C virus infection in elderly people has not been widely studied although an increase in the prevalence of this disease in the older population is expected. Material and Methods. This work presents the clinical and epidemiological characteristics of chronic hepatitis C in 153 patients aged 65 years and older who were treated at the Department of Infectious Diseases, Clinical Center of Vojvodina in Novi Sad. Results. Hepatitis C virus infection is slightly more prevalent in women - 55.55%; it is usually discovered accidentally during other examinations and is usually acquired after blood transfusion - 42.48% of cases. The average duration of infection was 28.48 years, the most common infection was caused by genotype 1 of the hepatitis C virus and histopathological examinations of liver biopsy usually revealed severe fibrosis and cirrhosis - 72.22% of cases. The success of the antiviral therapy applied in 16 patients was 62.50%. Conclusion. Antiviral therapy in elderly people is rarely used, but the success of 62.50% in our sample justifies the treatment of patients despite their age and comorbidities.

scholarly journals Pharmacokinetics, safety, and efficacy of glecaprevir/pibrentasvir in children with chronic hepatitis C virus: part 2 of the DORA study

Hepatology ◽  
2021 ◽  
Author(s):  
Maureen M Jonas ◽  
Susan Rhee ◽  
Deirdre A Kelly ◽  
Antonio Del Valle‐Segarra ◽  
Cornelia Feiterna‐Sperling ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Safety And Efficacy ◽  
Chronic Hepatitis C Virus

scholarly journals Pharmacokinetics, Safety, and Efficacy of Glecaprevir/Pibrentasvir in Adolescents With Chronic Hepatitis C Virus: Part 1 of the DORA Study

Hepatology ◽  
2019 ◽  
Vol 71 (2) ◽  
pp. 456-462 ◽  
Author(s):  
Maureen M. Jonas ◽  
Robert H. Squires ◽  
Susan M. Rhee ◽  
Chih‐Wei Lin ◽  
Kazuhiko Bessho ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Safety And Efficacy ◽  
Chronic Hepatitis C Virus

scholarly journals Long-term Antiviral Hepatitis C treatment associated with Rods and Ring Cytoplasmic antibodies

2019 ◽  
Vol 92 (1) ◽  
pp. 87-90 ◽  
Author(s):  
Vasile Feldrihan ◽  
Andreea Benea ◽  
Monica Lia Junie
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Antiviral Therapy ◽  
Chronic Hepatitis C ◽  
Clinical Case ◽  
Biological Evaluation ◽  
Hepatitis C Virus Infection ◽  
Chronic Hepatitis C Virus

Aim. Clinical description of a patient diagnosed with chronic hepatitis C virus infection, which associated a rare anti-cytoplasmic pattern, known as "Rods and Ring".Method. Clinical case report.Results. A 76-year old female patient with chronic hepatitis C virus infection under treatment for several months with pegylated Interferon-Ribavirin (started eight months ago) presented for clinical and biological evaluation of the therapeutic response.Conclusion. This is the first reported clinical case of a patient with cytoplasmic filamentous rods and rings autoantibodies associated with chronic hepatis C from the Clinical Hospital IRGH Prof. Dr. O. Fodor Cluj-Napoca, Romania. The presence of these antibodies appears to be triggered by antiviral therapy. Although these are newly identified antibodies, they could be used as serological markers for detecting patients at risk of developing associated autoimmune pathologies or nonresponders to the antiviral therapy. Likewise, their detection could identify patients with occult hepatitis C infection.

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