scholarly journals Multimodal Imaging with NanoGd Reveals Spatiotemporal Features of Neuroinflammation after Experimental Stroke

2021 ◽  
pp. 2101433
Author(s):  
Violaine Hubert ◽  
Ines Hristovska ◽  
Szilvia Karpati ◽  
Sarah Benkeder ◽  
Arindam Dey ◽  
...  
Keyword(s):  
Multimodal Imaging ◽  
Experimental Stroke ◽  
Spatiotemporal Features

scholarly journals Multimodal Imaging Reveals Temporal and Spatial Microglia and Matrix Metalloproteinase Activity after Experimental Stroke

2015 ◽  
Vol 35 (11) ◽  
pp. 1711-1721 ◽  
Author(s):  
Bastian Zinnhardt ◽  
Thomas Viel ◽  
Lydia Wachsmuth ◽  
Alexis Vrachimis ◽  
Stefan Wagner ◽  
...  
Keyword(s):  
Multimodal Imaging ◽  
Temporal Dynamics ◽  
Single Photon ◽  
Photon Emission ◽  
Temporal Distribution ◽  
Critical Parameters ◽  
Experimental Stroke ◽  
Emission Computed Tomography ◽  
Infarct Core ◽  
Spatio Temporal

Stroke is the most common cause of death and disability from neurologic disease in humans. Activation of microglia and matrix metalloproteinases (MMPs) is involved in positively and negatively affecting stroke outcome. Novel, noninvasive, multimodal imaging methods visualizing microglial and MMP alterations were employed. The spatio-temporal dynamics of these parameters were studied in relation to blood flow changes. Micro positron emission tomography (μPET) using [18F]BR-351 showed MMP activity within the first days after transient middle cerebral artery occlusion (tMCAo), followed by increased [18F]DPA-714 uptake as a marker for microglia activation with a maximum at 14 days after tMCAo. The inflammatory response was spatially located in the infarct core and in adjacent (penumbral) tissue. For the first time, multimodal imaging based on PET, single photon emission computed tomography, and magnetic resonance imaging revealed insight into the spatio-temporal distribution of critical parameters of poststroke inflammation. This allows further evaluation of novel treatment paradigms targeting the postischemic inflammation.

scholarly journals In vivo multimodal imaging of adenosine A1 receptors in neuroinflammation after experimental stroke

Theranostics ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 410-425
Author(s):  
Ana Joya ◽  
María Ardaya ◽  
Alejandro Montilla ◽  
Maider Garbizu ◽  
Sandra Plaza-García ◽  
...  
Keyword(s):  
Multimodal Imaging ◽  
Experimental Stroke ◽  
Adenosine A1 Receptors ◽  
Adenosine A1

Gender differences in isoflurane preconditioning and experimental stroke

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S290-S290
Author(s):  
Hideto Kitano ◽  
Patricia D Hurn ◽  
Stephanie J Murphy
Keyword(s):  
Gender Differences ◽  
Experimental Stroke
Sign in / Sign up

Export Citation Format

Share Document