scholarly journals Theranostic Nanomedicine for Synergistic Chemodynamic Therapy and Chemotherapy of Orthotopic Glioma

2020 ◽  
Vol 7 (24) ◽  
pp. 2003036
Author(s):  
Junyi Tan ◽  
Xiaohui Duan ◽  
Fang Zhang ◽  
Xiaohua Ban ◽  
Jiaji Mao ◽  
...  
Keyword(s):  
Orthotopic Glioma

Mifepristone Improves Antitumor Temozolamide Response in an Orthotopic Glioma Model

2017 ◽  
Vol 88 ◽  
pp. 231-232
Author(s):  
Monserrat Llaguno-Munive ◽  
Janeth Serrano-Bello ◽  
Mario Romero-Piña ◽  
Luis Medina ◽  
Norma Uribe-Uribe ◽  
...  
Keyword(s):  
Glioma Model ◽  
Orthotopic Glioma

scholarly journals TMOD-03. GLIOMAPDOX: A MOLECULARLY DIVERSE LIBRARY OF DIRECT-FROM-PATIENT ORTHOTOPIC GLIOMA XENOGRAFTS RECAPITULATES INTRATUMOR HETEROGENEITY

2018 ◽  
Vol 20 (suppl_6) ◽  
pp. vi268-vi269
Author(s):  
Nicholas Bayley ◽  
Lynn Baufeld ◽  
Laura Gosa ◽  
Danielle Morrow ◽  
Christopher Tse ◽  
...  
Keyword(s):  
Intratumor Heterogeneity ◽  
Orthotopic Glioma

Ultrasound Facilitates Naturally Equipped Exosomes Derived from Macrophages and Blood Serum for Orthotopic Glioma Treatment

2019 ◽  
Vol 11 (16) ◽  
pp. 14576-14587 ◽  
Author(s):  
Lianmei Bai ◽  
Yichen Liu ◽  
Kaili Guo ◽  
Kun Zhang ◽  
Quanhong Liu ◽  
...  
Keyword(s):  
Blood Serum ◽  
Orthotopic Glioma

scholarly journals CBMT-08. IN VIVO EVALUATION OF PENTOSE PHOSPHATE PATHWAY ACTIVITY IN ORTHOTOPIC GLIOMA USING HYPERPOLARIZED δ-[1-13C]GLUCONOLACTONE

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi34-vi34
Author(s):  
Georgios Batsios ◽  
Pavithra Viswanath ◽  
Peng Cao ◽  
Celine Taglang ◽  
Elavarasan Subramani ◽  
...  
Keyword(s):  
Pentose Phosphate Pathway ◽  
Tumor Development ◽  
Pentose Phosphate ◽  
Response To Therapy ◽  
Metabolic Imaging ◽  
Normal Brain ◽  
In Vivo Evaluation ◽  
First Time ◽  
Orthotopic Glioma

Abstract The pentose phosphate pathway (PPP) generates NADPH and ribose 5-phosphate, which are involved in the scavenging of reactive oxygen species and the synthesis of nucleotides. As such, the PPP is typically upregulated in cancer cells to address the metabolic needs of rapid cell proliferation. Imaging PPP upregulation could therefore be useful in tumor assessment. One intermediate of the pathway is 6-phospho-δ-gluconolactone (6P-δ-GL), which is produced by phosphorylation of δ-gluconolactone. 6P-δ-GL is further metabolized to 6-phospho-gluconate (6PG). The goal of our study was to evaluate, for the first time, whether hyperpolarized (HP) δ-[1-13C]gluconolactone can be used to assess PPP flux and detect the presence of tumor in an orthotopic glioma rat model. Athymic nude rats bearing orthotropic U87 tumors or age-matched tumor-free controls were investigated. HP studies were performed following intravenous injection of HP δ-[1-13C]gluconolactone and metabolic images using a flyback spectral-spatial echo-planar spectroscopic imaging pulse were acquired. The data were processed using in-house Matlab code. 6P-δ-GL and 6-phospho-γ-[1-13C]gluconolactone were observed in all rats ~10 seconds after HP δ-[1-13C]gluconolactone injection, followed ~5 seconds later by production of 6PG observed at 179.3ppm. These data indicate that HP δ-[1-13C]gluconolactone likely crosses the blood-brain barrier, consistent with its transport via glucose transporters, and is rapidly metabolized. Importantly, 6PG was significantly higher in tumor voxels. The ratio of 6PG-to-6P-δ-GL was comparable in normal brain and in normal-appearing contralateral brain of tumor-bearing rats at 0.43±0.09 and 0.45±0.06 respectively (p=0.85), but significant higher in the tumor regions at 0.70±0.11 (p=0.04 and p=0.02 respectively), consistent with the elevated PPP flux that typically occurs in tumor cells. Our results indicate, to our knowledge for the first time, that metabolism of HP δ-[1-13C]gluconolactone can be assessed in the brain and that elevated 6PG production in glioma provides a potential metabolic imaging approach to probe tumor development, recurrence and response to therapy.

scholarly journals EP-1351: Efficacy of combination treatments of a NOTCH inhibitor and chemoradiotherapy in an orthotopic glioma model

2015 ◽  
Vol 115 ◽  
pp. S728-S729
Author(s):  
S. Yahyanejad ◽  
P.V. Granton ◽  
S. Van Hoof ◽  
L. Barbeau ◽  
J. Theys ◽  
...  
Keyword(s):  
Combination Treatments ◽  
Glioma Model ◽  
Orthotopic Glioma

Effects of the VEGFR inhibitor ZD6474 in combination with radiotherapy and temozolomide in an orthotopic glioma model

2008 ◽  
Vol 88 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Maria Sandström ◽  
Mikael Johansson ◽  
Per Bergström ◽  
A. Tommy Bergenheim ◽  
Roger Henriksson
Keyword(s):  
Glioma Model ◽  
Vegfr Inhibitor ◽  
Orthotopic Glioma

Photoacoustic microscopy for evaluating combretastatin A4 phosphate induced vascular disruption in orthotopic glioma

2018 ◽  
Vol 11 (10) ◽  
pp. e201700327 ◽  
Author(s):  
Renzhe Bi ◽  
Ghayathri Balasundaram ◽  
Seungwan Jeon ◽  
Hui Chien Tay ◽  
Yang Pu ◽  
...  
Keyword(s):  
Photoacoustic Microscopy ◽  
Vascular Disruption ◽  
Combretastatin A4 ◽  
Orthotopic Glioma

scholarly journals Targeting Orthotopic Glioma in Mice with Genetically EngineeredSalmonella typhimurium

2014 ◽  
Vol 55 (3) ◽  
pp. 131 ◽  
Author(s):  
Min Wen ◽  
Shin Jung ◽  
Kyung-Sub Moon ◽  
Shen Nan Jiang ◽  
Song-Yuan Li ◽  
...  
Keyword(s):  
Orthotopic Glioma
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