scholarly journals Protein Arginine Methyltransferase PRMT5 Regulates Fatty Acid Metabolism and Lipid Droplet Biogenesis in White Adipose Tissues

2020 ◽  
Vol 7 (23) ◽  
pp. 2002602
Author(s):  
Zhihao Jia ◽  
Feng Yue ◽  
Xiyue Chen ◽  
Naagarajan Narayanan ◽  
Jiamin Qiu ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Lipid Droplet ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Protein Arginine Methyltransferase ◽  
Adipose Tissues ◽  
Arginine Methyltransferase

scholarly journals Lipid droplet‐dependent fatty acid metabolism controls the immune suppressive phenotype of tumor‐associated macrophages

2019 ◽  
Vol 11 (11) ◽  
Author(s):  
Hao Wu ◽  
Yijie Han ◽  
Yasmina Rodriguez Sillke ◽  
Hongzhang Deng ◽  
Sophiya Siddiqui ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Lipid Droplet ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Tumor Associated Macrophages ◽  
Suppressive Phenotype

scholarly journals EFFECT OF STARVATION ON FATTY ACID METABOLISM OF BROWN AND WHITE ADIPOSE TISSUES IN THE NEWBORN RABBIT

1974 ◽  
Vol 8 (4) ◽  
pp. 357-357
Author(s):  
Tibor Hein ◽  
Herwart Schenk ◽  
Hans Wagner ◽  
Lothar Winkler ◽  
Eberhardt Goetze ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Adipose Tissues ◽  
Newborn Rabbit

scholarly journals FATTY-ACID METABOLISM BY HUMAN ADIPOSE TISSUES*

1963 ◽  
Vol 42 (10) ◽  
pp. 1648-1652 ◽  
Author(s):  
M. Hamosh ◽  
P. Hamosh ◽  
J. A. Bar-Maor ◽  
H. Cohen
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Adipose Tissues

scholarly journals Integrative Analyses of mRNA Expression Profile Reveal SOCS2 and CISH Play Important Roles in GHR Mutation-Induced Excessive Abdominal Fat Deposition in the Sex-Linked Dwarf Chicken

2021 ◽  
Vol 11 ◽  
Author(s):  
Genghua Chen ◽  
Jiahui Chen ◽  
Jingwen Wu ◽  
Xueyi Ren ◽  
Limin Li ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Lipid Droplet ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Abdominal Fat ◽  
Fat Deposition ◽  
Recessive Mutation ◽  
Regulatory Pathways ◽  
Key Genes ◽  
Abdominal Fat Deposition

Sex-linked dwarf (SLD) chicken, which is caused by a recessive mutation of the growth hormone receptor (GHR), has been widely used in the Chinese broiler industry. However, it has been found that the SLD chicken has more abdominal fat deposition than normal chicken. Excessive fat deposition not only reduced the carcass quality of the broilers but also reduced the immunity of broilers to diseases. To find out the key genes and the precise regulatory pathways that were involved in the GHR mutation-induced excessive fat deposition, we used high-fat diet (HFD) and normal diet to feed the SLD chicken and normal chicken and analyzed the differentially expressed genes (DEGs) among the four groups. Results showed that the SLD chicken had more abdominal fat deposition and larger adipocytes size than normal chicken and HFD can promote abdominal fat deposition and induce adipocyte hypertrophy. RNA sequencing results of the livers and abdominal fats from the above chickens revealed that many DEGs between the SLD and normal chickens were enriched in fat metabolic pathways, such as peroxisome proliferator-activated receptor (PPAR) signaling, extracellular matrix (ECM)-receptor pathway, and fatty acid metabolism. Importantly, by constructing and analyzing the GHR-downstream regulatory network, we found that suppressor of cytokine signaling 2 (SOCS2) and cytokine-inducible SH2-containing protein (CISH) may involve in the GHR mutation-induced abdominal fat deposition in chicken. The ectopic expression of SOCS2 and CISH in liver-related cell line leghorn strain M chicken hepatoma (LMH) cell and immortalized chicken preadipocytes (ICP) revealed that these two genes can regulate fatty acid metabolism, adipocyte differentiation, and lipid droplet accumulation. Notably, overexpression of SOCS2 and CISH can rescue the hyperactive lipid metabolism and excessive lipid droplet accumulation of primary liver cell and preadipocytes that were isolated from the SLD chicken. This study found some genes and pathways involved in abdominal fat deposition of the SLD chicken and reveals that SOCS2 and CISH are two key genes involved in the GHR mutation-induced excessive fat deposition of the SLD chicken.

The Influence of Lactate and Dipyridamole on Myocardial Fatty Acid Metabolism in Man, Traced with 123l-17-lodo-heptadecanoic Acid

1990 ◽  
Vol 29 (01) ◽  
pp. 28-34 ◽  
Author(s):  
F. C. Visser ◽  
M. J. van Eenige ◽  
G. Westera ◽  
J. P. Roos ◽  
C. M. B. Duwel
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Time Activity ◽  
Time Value ◽  
Myocardial Fatty Acid Metabolism ◽  
Coronary Vasodilatation ◽  
Activity Curve ◽  
Normal Human ◽  
Plasma Lactate Level

Changes in myocardial metabolism can be detected externally by registration of time-activity curves after administration of radioiodinated fatty acids. In this scintigraphic study the influence of lactate on fatty acid metabolism was investigated in the normal human myocardium, traced with 123l-17-iodoheptadecanoic acid (123l-17-HDA). In patients (paired, n = 7) lactate loading decreased the uptake of 123l-17-HDA significantly from 27 (control: 22-36) to 20 counts/min/pixel (16-31; p <0.05 Wilcoxon). The half-time value increased to more than 60 rriin (n = 5), oxidation decreased from 61 to 42%. Coronary vasodilatation, a well-known side effect of lactate loading, was studied separately in a dipyridamole study (paired, n = 6). Coronary vasodilatation did not influence the parameters of the time-activity curve. These results suggest that changes in plasma lactate level as occurring, among other effects, during exercise will influence the parameters of dynamic 123l-17-HDA scintigraphy of the heart.

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