scholarly journals The Nuclear Orphan Receptor NR2F6 Promotes Hepatic Steatosis through Upregulation of Fatty Acid Transporter CD36

2020 ◽  
Vol 7 (21) ◽  
pp. 2002273
Author(s):  
Bing Zhou ◽  
Lijing Jia ◽  
Zhijian Zhang ◽  
Liping Xiang ◽  
Youwen Yuan ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Hepatic Steatosis ◽  
Orphan Receptor ◽  
Fatty Acid Transporter ◽  
Acid Transporter ◽  
Nuclear Orphan Receptor

scholarly journals Fatty acid transporter expression and regulation is impaired in placental macrovascular endothelial cells in obese women

2017 ◽  
Vol 32 (6) ◽  
pp. 971-978 ◽  
Author(s):  
Xiaohua Yang ◽  
Patricia Glazebrook ◽  
Geraldine C. Ranasinghe ◽  
Maricela Haghiac ◽  
Virtu Calabuig-Navarro ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Fatty Acid ◽  
Obese Women ◽  
Fatty Acid Transporter ◽  
Acid Transporter ◽  
Transporter Expression

scholarly journals Hyperinsulinemia Enhances Hepatic Expression of the Fatty Acid Transporter Cd36 and Provokes Hepatosteatosis and Hepatic Insulin Resistance

2015 ◽  
Vol 290 (31) ◽  
pp. 19034-19043 ◽  
Author(s):  
Pär Steneberg ◽  
Alexandros G. Sykaras ◽  
Fredrik Backlund ◽  
Jurate Straseviciene ◽  
Ingegerd Söderström ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acid ◽  
Hepatic Insulin Resistance ◽  
Hepatic Expression ◽  
Fatty Acid Transporter ◽  
Acid Transporter

scholarly journals Phenomics reveals a novel putative chloroplast fatty acid transporter in the marine diatom Skeletonema marinoi involved in temperature acclimation

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Oskar N. Johansson ◽  
Mats Töpel ◽  
Jenny Egardt ◽  
Matthew I. M. Pinder ◽  
Mats X. Andersson ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Temperature Acclimation ◽  
Marine Diatom ◽  
Specific Gene ◽  
Hypothetical Proteins ◽  
Omega 3 ◽  
Fatty Acid Transporter ◽  
Future Value ◽  
Acid Transporter

Abstract Diatoms are the dominant phytoplankton in temperate oceans and coastal regions and yet little is known about the genetic basis underpinning their global success. Here, we address this challenge by developing the first phenomic approach for a diatom, screening a collection of randomly mutagenized but identifiably tagged transformants. Based upon their tolerance to temperature extremes, several compromised mutants were identified revealing genes either stress related or encoding hypothetical proteins of unknown function. We reveal one of these hypothetical proteins is a novel putative chloroplast fatty acid transporter whose loss affects several fatty acids including the two omega-3, long-chain polyunsaturated fatty acids - eicosapentaenoic and docosahexaenoic acid, both of which have medical importance as dietary supplements and industrial significance in aquaculture and biofuels. This mutant phenotype not only provides new insights into the fatty acid biosynthetic pathways in diatoms but also highlights the future value of phenomics for revealing specific gene functions in these ecologically important phytoplankton.

scholarly journals Nuclear Orphan Receptor TAK1/TR4-Deficient Mice Are Protected Against Obesity-Linked Inflammation, Hepatic Steatosis, and Insulin Resistance

Diabetes ◽  
2010 ◽  
Vol 60 (1) ◽  
pp. 177-188 ◽  
Author(s):  
Hong Soon Kang ◽  
Kyoko Okamoto ◽  
Yong-Sik Kim ◽  
Yukimasa Takeda ◽  
Carl D. Bortner ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Hepatic Steatosis ◽  
Orphan Receptor ◽  
Nuclear Orphan Receptor ◽  
Deficient Mice
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