scholarly journals Tumor Imaging: Radiopharmaceuticals and Fluorescein Sodium Mediated Triple-Modality Molecular Imaging Allows Precise Image-Guided Tumor Surgery (Adv. Sci. 13/2019)

2019 ◽  
Vol 6 (13) ◽  
pp. 1970081
Author(s):  
Sheng Zheng ◽  
Zeyu Zhang ◽  
Yawei Qu ◽  
Xiaojun Zhang ◽  
Hongbo Guo ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Tumor Imaging ◽  
Tumor Surgery ◽  
Fluorescein Sodium ◽  
Image Guided

scholarly journals Radiopharmaceuticals and Fluorescein Sodium Mediated Triple‐Modality Molecular Imaging Allows Precise Image‐Guided Tumor Surgery

2019 ◽  
Vol 6 (13) ◽  
pp. 1900159 ◽  
Author(s):  
Sheng Zheng ◽  
Zeyu Zhang ◽  
Yawei Qu ◽  
Xiaojun Zhang ◽  
Hongbo Guo ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Tumor Surgery ◽  
Fluorescein Sodium ◽  
Image Guided

scholarly journals Radiopharmaceutical and Eu3+ doped gadolinium oxide nanoparticles mediated triple-excited fluorescence imaging and image-guided surgery

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Xiaojing Shi ◽  
Caiguang Cao ◽  
Zeyu Zhang ◽  
Jie Tian ◽  
Zhenhua Hu
Keyword(s):  
Fluorescent Probes ◽  
Signal Intensity ◽  
Tumor Imaging ◽  
Tumor Resection ◽  
Optical Signal ◽  
Gadolinium Oxide ◽  
Image Guided Surgery ◽  
Guided Surgery ◽  
Image Guided ◽  
The Impact

AbstractCerenkov luminescence imaging (CLI) is a novel optical imaging technique that has been applied in clinic using various radionuclides and radiopharmaceuticals. However, clinical application of CLI has been limited by weak optical signal and restricted tissue penetration depth. Various fluorescent probes have been combined with radiopharmaceuticals for improved imaging performances. However, as most of these probes only interact with Cerenkov luminescence (CL), the low photon fluence of CL greatly restricted it’s interaction with fluorescent probes for in vivo imaging. Therefore, it is important to develop probes that can effectively convert energy beyond CL such as β and γ to the low energy optical signals. In this study, a Eu3+ doped gadolinium oxide (Gd2O3:Eu) was synthesized and combined with radiopharmaceuticals to achieve a red-shifted optical spectrum with less tissue scattering and enhanced optical signal intensity in this study. The interaction between Gd2O3:Eu and radiopharmaceutical were investigated using 18F-fluorodeoxyglucose (18F-FDG). The ex vivo optical signal intensity of the mixture of Gd2O3:Eu and 18F-FDG reached 369 times as high as that of CLI using 18F-FDG alone. To achieve improved biocompatibility, the Gd2O3:Eu nanoparticles were then modified with polyvinyl alcohol (PVA), and the resulted nanoprobe PVA modified Gd2O3:Eu (Gd2O3:Eu@PVA) was applied in intraoperative tumor imaging. Compared with 18F-FDG alone, intraoperative administration of Gd2O3:Eu@PVA and 18F-FDG combination achieved a much higher tumor-to-normal tissue ratio (TNR, 10.24 ± 2.24 vs. 1.87 ± 0.73, P = 0.0030). The use of Gd2O3:Eu@PVA and 18F-FDG also assisted intraoperative detection of tumors that were omitted by preoperative positron emission tomography (PET) imaging. Further experiment of image-guided surgery demonstrated feasibility of image-guided tumor resection using Gd2O3:Eu@PVA and 18F-FDG. In summary, Gd2O3:Eu can achieve significantly optimized imaging property when combined with 18F-FDG in intraoperative tumor imaging and image-guided tumor resection surgery. It is expected that the development of the Gd2O3:Eu nanoparticle will promote investigation and application of novel nanoparticles that can interact with radiopharmaceuticals for improved imaging properties. This work highlighted the impact of the nanoprobe that can be excited by radiopharmaceuticals emitting CL, β, and γ radiation for precisely imaging of tumor and intraoperatively guide tumor resection.

scholarly journals Indocyanine Green-Loaded Nanoparticles for Image-Guided Tumor Surgery

2015 ◽  
Vol 26 (2) ◽  
pp. 294-303 ◽  
Author(s):  
Tanner K. Hill ◽  
Asem Abdulahad ◽  
Sneha S. Kelkar ◽  
Frank C. Marini ◽  
Timothy E. Long ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Tumor Surgery ◽  
Image Guided

scholarly journals Diketopyrrolopyrrole-based semiconducting polymer nanoparticles forin vivosecond near-infrared window imaging and image-guided tumor surgery

2018 ◽  
Vol 9 (12) ◽  
pp. 3105-3110 ◽  
Author(s):  
Kangquan Shou ◽  
Yufu Tang ◽  
Hao Chen ◽  
Si Chen ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Near Infrared ◽  
Polymer Nanoparticles ◽  
Absorption Peak ◽  
Tumor Surgery ◽  
Clinical Imaging ◽  
Semiconducting Polymer ◽  
Image Guided ◽  
Infrared Window ◽  
Semiconducting Polymer Nanoparticles

PDFT1032, a new semiconducting polymer possessing a favorable absorption peak (1032 nm) and outstanding biocompatibility, may be widely applicable in clinical imaging and the surgical treatment of malignancy.

Fluorescein sodium in brain tumor surgery – Response

2013 ◽  
Vol 155 (12) ◽  
pp. 2253-2254 ◽  
Author(s):  
Karl-Michael Schebesch ◽  
Martin Proescholdt ◽  
Alexander Brawanski
Keyword(s):  
Brain Tumor ◽  
Tumor Surgery ◽  
Fluorescein Sodium ◽  
Brain Tumor Surgery

scholarly journals Novel bright-emission small-molecule NIR-II fluorophores for in vivo tumor imaging and image-guided surgery

2017 ◽  
Vol 8 (5) ◽  
pp. 3489-3493 ◽  
Author(s):  
Yao Sun ◽  
Mingmin Ding ◽  
Xiaodong Zeng ◽  
Yuling Xiao ◽  
Huaping Wu ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Small Molecule ◽  
Tumor Imaging ◽  
Image Guided Surgery ◽  
Guided Surgery ◽  
Image Guided ◽  
Bright Emission

This work presents the establishment of novel bright-emission small-molecule NIR-II fluorophores forin vivotumor imaging and NIR-II image-guided sentinel lymph node surgery.

Fluorescence molecular imaging systems for intraoperative image-guided surgery

2017 ◽  
Vol 53 (2-4) ◽  
pp. 349-359 ◽  
Author(s):  
Taehoon Kim ◽  
Connor O'Brien ◽  
Hak Soo Choi ◽  
Myung Yung Jeong
Keyword(s):  
Molecular Imaging ◽  
Imaging Systems ◽  
Image Guided Surgery ◽  
Guided Surgery ◽  
Image Guided ◽  
Fluorescence Molecular Imaging
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