scholarly journals Tumor-Specific Drug Release and Reactive Oxygen Species Generation for Cancer Chemo/Chemodynamic Combination Therapy

2019 ◽  
Vol 6 (5) ◽  
pp. 1801986 ◽  
Author(s):  
Sheng Wang ◽  
Zhantong Wang ◽  
Guocan Yu ◽  
Zijian Zhou ◽  
Orit Jacobson ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Release ◽  
Combination Therapy ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Specific Drug ◽  
Oxygen Species

Enhanced Antitumor Efficacy by a Cascade of Reactive Oxygen Species Generation and Drug Release

2019 ◽  
Vol 131 (41) ◽  
pp. 14900-14905 ◽  
Author(s):  
Sheng Wang ◽  
Guocan Yu ◽  
Zhantong Wang ◽  
Orit Jacobson ◽  
Li‐Sen Lin ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Release ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Antitumor Efficacy ◽  
Oxygen Species

scholarly journals Author Correction: Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Wenjia Zhang ◽  
Xianglong Hu ◽  
Qi Shen ◽  
Da Xing
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Release ◽  
Reactive Oxygen ◽  
Specific Drug ◽  
Oxygen Species ◽  
Reactive Oxygen Species Burst

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Enhanced Antitumor Efficacy by a Cascade of Reactive Oxygen Species Generation and Drug Release

2019 ◽  
Vol 58 (41) ◽  
pp. 14758-14763 ◽  
Author(s):  
Sheng Wang ◽  
Guocan Yu ◽  
Zhantong Wang ◽  
Orit Jacobson ◽  
Li‐Sen Lin ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Release ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Antitumor Efficacy ◽  
Oxygen Species

Роль оксида азота в реализации антиоксидантного эффекта неопиатного аналога лей-энкефалина в сердце новорожденных белых крыс

2019 ◽  
pp. 61-64
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Postnatal Period ◽  
Oxide System ◽  
No Synthase ◽  
Albino Rats ◽  
Oxygen Species ◽  
Control Parameters ◽  
Synthase Inhibitor

The eff ect of the non-opiate analog of leu-enkephalin (peptide NALE: Phe – D – Ala – Gly – Phe – Leu – Arg) on the reactive oxygen species generation in the heart of albino rats in the early postnatal period was studied. Peptide NALE was administered intraperitoneally in the dose of 100 μ/kg daily from 2 to 6 days of life. Reactive oxygen species generation was assessed by chemiluminescence in the heart homogenates of 7-day-old animals. Decreasing of reactive oxygen species generation nearly by 30 % and an increasing in antioxidant system activity by the 20-27 %, compared with the control parameters, were found. The antioxidant eff ect of peptide NALE is associated with the presence of the amino acid Arg in the structure of the peptide. An analogue of NALE peptide, devoid of Arg (peptide Phe – D – Ala – Gly – Phe – Leu – Gly), had a signifi cant lower antioxidant eff ect. The NO-synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) in the dose 50 mg/kg, administered with NALE peptide, reduced the severity of the NALE antioxidant eff ect. The results of the study suggest that the pronounced antioxidant eff ect of NALE peptide in the heart of albino rats, at least in part, is due to the interaction with the nitric oxide system.

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