scholarly journals ATG7 Promotes Bladder Cancer Invasion via Autophagy‐Mediated Increased ARHGDIB mRNA Stability

2019 ◽  
Vol 6 (8) ◽  
pp. 1801927 ◽  
Author(s):  
Junlan Zhu ◽  
Zhongxian Tian ◽  
Yang Li ◽  
Xiaohui Hua ◽  
Dongyun Zhang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Mrna Stability ◽  
Cancer Invasion

scholarly journals ATG7 Promotes Bladder Cancer Invasion via Autophagy‐Mediated Increased ARHGDIB mRNA Stability

2021 ◽  
Vol 8 (22) ◽  
pp. 2104365
Author(s):  
Junlan Zhu ◽  
Zhongxian Tian ◽  
Yang Li ◽  
Xiaohui Hua ◽  
Dongyun Zhang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Mrna Stability ◽  
Cancer Invasion

scholarly journals XIAP overexpression promotes bladder cancer invasion in vitro and lung metastasis in vivo via enhancing nucleolin-mediated Rho-GDIβ mRNA stability

2017 ◽  
Vol 142 (10) ◽  
pp. 2040-2055 ◽  
Author(s):  
Yonghui Yu ◽  
Honglei Jin ◽  
Jiheng Xu ◽  
Jiayan Gu ◽  
Xin Li ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Lung Metastasis ◽  
Mrna Stability ◽  
Cancer Invasion

scholarly journals Androgen receptor‐regulated circ FNTA activates KRAS signaling to promote bladder cancer invasion

EMBO Reports ◽  
2020 ◽  
Vol 21 (4) ◽  
Author(s):  
Jinbo Chen ◽  
Yin Sun ◽  
Zhenyu Ou ◽  
Shuyuan Yeh ◽  
Chi‐Ping Huang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Androgen Receptor ◽  
Cancer Invasion

scholarly journals Wnt7a and miR-370-3p: new contributors to bladder cancer invasion

Biotarget ◽  
2018 ◽  
Vol 2 ◽  
pp. 14-14
Author(s):  
Danielle Scheunemann ◽  
Anjan K. Pradhan ◽  
Swadesh K. Das ◽  
Devanand Sarkar ◽  
Luni Emdad ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Invasion

The Role of Actinin-4 in Bladder Cancer Invasion

Urology ◽  
2010 ◽  
Vol 75 (2) ◽  
pp. 357-364 ◽  
Author(s):  
Takahiro Koizumi ◽  
Hiroyoshi Nakatsuji ◽  
Tomoya Fukawa ◽  
Shiirevnyamba Avirmed ◽  
Tomoharu Fukumori ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Invasion

Inhibition of bladder cancer invasion by Sp1-mediated BTG2 expression via inhibition of DNA methyltransferase 1

FEBS Journal ◽  
2014 ◽  
Vol 281 (24) ◽  
pp. 5581-5601 ◽  
Author(s):  
Preethi Devanand ◽  
Sun Il Kim ◽  
Yong Won Choi ◽  
Seung Soo Sheen ◽  
Hyunee Yim ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Dna Methyltransferase ◽  
Cancer Invasion ◽  
Dna Methyltransferase 1 ◽  
Methyltransferase 1

scholarly journals RhoGDIβ promotes Sp1/MMP-2 expression and bladder cancer invasion through perturbing miR-200c-targeted JNK2 protein translation

2017 ◽  
Vol 11 (11) ◽  
pp. 1579-1594 ◽  
Author(s):  
Haishan Huang ◽  
Honglei Jin ◽  
Huirong Zhao ◽  
Jingjing Wang ◽  
Xin Li ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Protein Translation ◽  
Cancer Invasion

scholarly journals Upregulation of RBM24 Exacerbates Bladder Cancer Progression by Formatting Runx1t1/TCF4/miR-625-5p Feedback Loop

2020 ◽  
Author(s):  
Yue-Wei Yin ◽  
Kai-Long Liu ◽  
Bao-Sai Lu ◽  
Wei Li ◽  
Ya-Lin Niu ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Transcription Factor ◽  
Cancer Progression ◽  
Mrna Stability ◽  
Feedback Loop ◽  
Rna Binding ◽  
Luciferase Assay ◽  
Proximity Ligation Assay ◽  
Binding Motif ◽  
Mrna Levels

Abstract Background: RNA-binding motif protein 24 (RBM24) acts as a multifunctional determinant of cell fate, proliferation, apoptosis, and differentiation during development through regulation of pre-mRNA splicing and mRNA stability. It is also implicated in carcinogenesis, but the functions of RBM24 in bladder cancer (BC) remains unclear.Methods: Cell viability was examined by colony forming and MTT assays. Real-time quantitative PCR (RT-qPCR) and western blot analysis were used to detect the protein and mRNA levels. Co-immunoprecipitation (CoIP) and proximity ligation assay (PLA) were used to determine the protein-protein interaction. Chromatin immunoprecipitation (ChIP), RNA immunoprecipitation (RIP), and oligo pull-down assays were used to verify DNA/RNA–protein interactions. Luciferase assay analysis was used to detect effects on transcription factor activity.Results: In the present study, we revealed that RBM24 was upregulated in BC tissues. Importantly, we found that higher level of RBM24 was correlated with poor prognosis in BC patients. Overexpression of RBM24 promoted while depletion of RBM24 inhibited BC cell proliferation in vivo and in vitro. Mechanically, RBM24 positively regulated Runx1t1 expression in BC cells by binding to and enhancing Runx1t1 mRNA stability. Runx1t1 in turn promoted RBM24 expression by interacting with TCF4. Furthermore, Runx1t1 in turn promoted RBM24 expression by interacting with the transcription factor TCF4 and depressing transcription of miR-625-5p, which directly targets and normally suppresses RBM24 expression. RBM24-regulated BC cells proliferation was moderated via the Runx1t1/TCF4/miR-625-5p feedback loop.Conclusions: In summary, these results indicate that a RBM24/Runx1t1/TCF4/miR-625-5p positive feedback loop plays a key role in BC oncogenesis. Disruption of this pathway may be a potential therapeutic strategy for BC treatment.

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