scholarly journals A Light-Triggered Mesenchymal Stem Cell Delivery System for Photoacoustic Imaging and Chemo-Photothermal Therapy of Triple Negative Breast Cancer

2018 ◽  
Vol 5 (10) ◽  
pp. 1800382 ◽  
Author(s):  
Chang Xu ◽  
Qishuai Feng ◽  
Haocheng Yang ◽  
Guangxue Wang ◽  
Liqun Huang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Delivery System ◽  
Triple Negative Breast Cancer ◽  
Photothermal Therapy ◽  
Triple Negative ◽  
Photoacoustic Imaging ◽  
Cell Delivery ◽  
Stem Cell Delivery

scholarly journals Adipose derived mesenchymal stem cell secretome formulation as a biotherapeutic to inhibit growth of drug resistant triple negative breast cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ragima Nadesh ◽  
Krishnakumar N. Menon ◽  
Lalitha Biswas ◽  
Ullas Mony ◽  
K. Subramania Iyer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Standard Of Care ◽  
Breast Cancer Cell Lines ◽  
Dependent Manner

AbstractIn the present study, a protocol was developed for processing of human adipose derived mesenchymal stem cell secretome formulation of varying concentration. Its molecular composition was evaluated, and its effectiveness in vitro using breast cancer cell lines, and in vivo in a nude mice breast cancer model was studied to determine its role in suppressing triple negative breast cancer in a dose dependent manner. Because the secretome could have value as an add-on therapy along with a current drug, the effectiveness of the secretome both in monotherapy and in combination therapy along with paclitaxel was evaluated. The results showed significant cell kill when exposed to the secretome above 20 mg/ml at which concentration there was no toxicity to normal cells. 70 mg/ml of SF showed 90 ± 10% apoptosis and significant decrease in CD44+/CD24−, MDR1+ and PDL-1+ cancer cells. In vivo, the tumor showed no growth after daily intra tumor injections at 50 mg/ml and 100 mg/ml doses whereas substantial tumor growth occurred after saline intra tumor injection. The study concludes that SF is a potential biotherapeutic for breast cancer and could be used initially as an add-on therapy to other standard of care to provide improved efficacy without other adverse effects.

Novel mesenchymal stem cell delivery system as targeted therapy against neuroblastoma using the TH-MYCN mouse model

2019 ◽  
Vol 54 (12) ◽  
pp. 2600-2605 ◽  
Author(s):  
Junnosuke Maniwa ◽  
Shigehisa Fumino ◽  
Koseki Kimura ◽  
Tomoko Tanaka ◽  
Mayumi Higashi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Targeted Therapy ◽  
Mesenchymal Stem Cell ◽  
Mouse Model ◽  
Delivery System ◽  
Cell Delivery ◽  
Stem Cell Delivery

scholarly journals The effect of human placental chorionic villi derived mesenchymal stem cell on triple-negative breast cancer hallmarks

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0207593 ◽  
Author(s):  
Alaa T. Alshareeda ◽  
Emad Rakha ◽  
Ayidah Alghwainem ◽  
Bahauddeen Alrfaei ◽  
Batla Alsowayan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Chorionic Villi ◽  
Cancer Hallmarks

scholarly journals Isolation and Establishment of a Highly Proliferative, Cancer Stem Cell-Like, and Naturally Immortalized Triple-Negative Breast Cancer Cell Line, KAIMRC2

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1303
Author(s):  
Rizwan Ali ◽  
Hajar Al Zahrani ◽  
Tlili Barhoumi ◽  
Alshaimaa Alhallaj ◽  
Abdullah Mashhour ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Line ◽  
Cancer Cell ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cell Line ◽  
Triple Negative ◽  
Cancer Cell Line

In vitro studies of a disease are key to any in vivo investigation in understanding the disease and developing new therapy regimens. Immortalized cancer cell lines are the best and easiest model for studying cancer in vitro. Here, we report the establishment of a naturally immortalized highly tumorigenic and triple-negative breast cancer cell line, KAIMRC2. This cell line is derived from a Saudi Arabian female breast cancer patient with invasive ductal carcinoma. Immunocytochemistry showed a significant ratio of the KAIMRC2 cells’ expressing key breast epithelial and cancer stem cells (CSCs) markers, including CD47, CD133, CD49f, CD44, and ALDH-1A1. Gene and protein expression analysis showed overexpression of ABC transporter and AKT-PI3Kinase as well as JAK/STAT signaling pathways. In contrast, the absence of the tumor suppressor genes p53 and p73 may explain their high proliferative index. The mice model also confirmed the tumorigenic potential of the KAIMRC2 cell line, and drug tolerance studies revealed few very potent candidates. Our results confirmed an aggressive phenotype with metastatic potential and cancer stem cell-like characteristics of the KAIMR2 cell line. Furthermore, we have also presented potent small molecule inhibitors, especially Ryuvidine, that can be further developed, alone or in synergy with other potent inhibitors, to target multiple cancer-related pathways.

scholarly journals Mesenchymal Stem Cell Delivery of TRAIL Can Eliminate Metastatic Cancer

2009 ◽  
Vol 69 (10) ◽  
pp. 4134-4142 ◽  
Author(s):  
Michael R. Loebinger ◽  
Ayad Eddaoudi ◽  
Derek Davies ◽  
Sam M. Janes
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Metastatic Cancer ◽  
Cell Delivery ◽  
Stem Cell Delivery

scholarly journals Near-infrared photothermal therapy using anti-EGFR-gold nanorod conjugates for triple negative breast cancer

Oncotarget ◽  
2017 ◽  
Vol 8 (49) ◽  
pp. 86566-86575 ◽  
Author(s):  
Meihua Zhang ◽  
Hoe Suk Kim ◽  
Tiefeng Jin ◽  
Jisu Woo ◽  
Yin Ji Piao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Triple Negative ◽  
Gold Nanorod
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