scholarly journals Recent Advances of Activatable Molecular Probes Based on Semiconducting Polymer Nanoparticles in Sensing and Imaging

2017 ◽  
Vol 4 (6) ◽  
pp. 1600481 ◽  
Author(s):  
Yan Lyu ◽  
Kanyi Pu
Keyword(s):  
Molecular Probes ◽  
Polymer Nanoparticles ◽  
Semiconducting Polymer ◽  
Recent Advances ◽  
Semiconducting Polymer Nanoparticles

Engineering fluorescent semiconducting polymer nanoparticles for biological applications and beyond

2021 ◽  
Vol 57 (16) ◽  
pp. 1989-2004
Author(s):  
Junyong Sun ◽  
Qiang Zhang ◽  
Xiaomei Dai ◽  
Pinghua Ling ◽  
Feng Gao
Keyword(s):  
Polymer Nanoparticles ◽  
Biological Applications ◽  
Semiconducting Polymer ◽  
Recent Advances ◽  
Semiconducting Polymer Nanoparticles

We summarize the recent advances in engineering approaches to obtain functionalized semiconducting polymer nanoparticles (SPNs) for biological applications. The challenges and outlook of fabricating functionalized SPNs are also provided.

scholarly journals Functionalized NIR-II Semiconducting Polymer Nanoparticles for Single-Cell to Whole-Organ Imaging of PSMA-Positive Prostate Cancer

2019 ◽  
Author(s):  
Jiayingzi Wu ◽  
Hyeon-Jeong Lee ◽  
Liyan You ◽  
Xuyi Luo ◽  
Tsukasa Hasegawa ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Single Cell ◽  
Transient Absorption ◽  
Tissue Level ◽  
Cellular Level ◽  
Molecular Probes ◽  
Polymer Nanoparticles ◽  
Great Promise ◽  
Semiconducting Polymer ◽  
Semiconducting Polymer Nanoparticles

<p>Development of specific molecular probes holds great promise for early diagnosis of aggressive prostate cancer (PCa). Here, 2-[3-(1,3-dicarboxypropyl) ureido] pentanedioic acid (DUPA)-conjugated ligand and bis-isoindigo-based polymer (BTII) are synthesized to formulate semiconducting polymer nanoparticles (BTII-DUPA SPN) as a prostate-specific membrane antigen (PSMA)-targeted probe for PCa imaging in the NIR-II window. Insights into the interaction of the imaging probes with the biological targets from single-cell to whole-organ levels are obtained by transient absorption microscopy (TAM) and photoacoustic tomography (PAT). The targeting mechanism, kinetics, and specificity of BTII-DUPA SPN to PSMA-positive PCa cells are revealed at cellular level with TAM. At the organ level, PAT imaging of BTII-DUPA SPN in the NIR-II window demonstrates superior penetration depth and imaging contrast. By intravenous administration, BTII-DUPA SPN demonstrates selective accumulation and retention in the PSMA-positive tumor, allowing noninvasive PAT detection of PSMA overexpressing PCa. The distribution of nanoparticles at tissue level is further analyzed through TAM. These results collectively demonstrate a new SPN for targeted cancer detection by TAM and PAT imaging.</p>

scholarly journals Functionalized NIR-II Semiconducting Polymer Nanoparticles for Single-Cell to Whole-Organ Imaging of PSMA-Positive Prostate Cancer

2019 ◽  
Author(s):  
Jiayingzi Wu ◽  
Hyeon-Jeong Lee ◽  
Liyan You ◽  
Xuyi Luo ◽  
Tsukasa Hasegawa ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Single Cell ◽  
Transient Absorption ◽  
Tissue Level ◽  
Cellular Level ◽  
Molecular Probes ◽  
Polymer Nanoparticles ◽  
Great Promise ◽  
Semiconducting Polymer ◽  
Semiconducting Polymer Nanoparticles

<p>Development of specific molecular probes holds great promise for early diagnosis of aggressive prostate cancer (PCa). Here, 2-[3-(1,3-dicarboxypropyl) ureido] pentanedioic acid (DUPA)-conjugated ligand and bis-isoindigo-based polymer (BTII) are synthesized to formulate semiconducting polymer nanoparticles (BTII-DUPA SPN) as a prostate-specific membrane antigen (PSMA)-targeted probe for PCa imaging in the NIR-II window. Insights into the interaction of the imaging probes with the biological targets from single-cell to whole-organ levels are obtained by transient absorption microscopy (TAM) and photoacoustic tomography (PAT). The targeting mechanism, kinetics, and specificity of BTII-DUPA SPN to PSMA-positive PCa cells are revealed at cellular level with TAM. At the organ level, PAT imaging of BTII-DUPA SPN in the NIR-II window demonstrates superior penetration depth and imaging contrast. By intravenous administration, BTII-DUPA SPN demonstrates selective accumulation and retention in the PSMA-positive tumor, allowing noninvasive PAT detection of PSMA overexpressing PCa. The distribution of nanoparticles at tissue level is further analyzed through TAM. These results collectively demonstrate a new SPN for targeted cancer detection by TAM and PAT imaging.</p>

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