scholarly journals Reactive-Oxygen-Species-Responsive Drug Delivery Systems: Promises and Challenges

2016 ◽  
Vol 4 (1) ◽  
pp. 1600124 ◽  
Author(s):  
Gurusamy Saravanakumar ◽  
Jihoon Kim ◽  
Won Jong Kim
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Reactive Oxygen ◽  
Delivery Systems ◽  
Oxygen Species

scholarly journals Reactive oxygen species-responsive drug delivery systems for the treatment of neurodegenerative diseases

Biomaterials ◽  
2019 ◽  
Vol 217 ◽  
pp. 119292 ◽  
Author(s):  
William C. Ballance ◽  
Ellen C. Qin ◽  
Hee Jung Chung ◽  
Martha U. Gillette ◽  
Hyunjoon Kong
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Delivery ◽  
Neurodegenerative Diseases ◽  
Drug Delivery Systems ◽  
Reactive Oxygen ◽  
Delivery Systems ◽  
Oxygen Species

A reactive oxygen species–responsive prodrug micelle with efficient cellular uptake and excellent bioavailability

2018 ◽  
Vol 6 (7) ◽  
pp. 1076-1084 ◽  
Author(s):  
Long Xu ◽  
Yidi Yang ◽  
Mingying Zhao ◽  
Wenxia Gao ◽  
Hai Zhang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Delivery Systems ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Stimuli Responsive ◽  
Poly Ethylene Glycol ◽  
Polymeric Drug Delivery ◽  
Polymeric Drug ◽  
Poly Ethylene ◽  
Polymeric Drug Delivery Systems

Stimuli-responsive polymeric drug delivery systems are of great interest in anticancer research. Here, a reactive oxygen species (ROS)–responsive prodrug was prepared by thioketal linkage of poly(ethylene glycol) (PEG) and the anticancer drug doxorubicin (DOX).

Specific Cancer Cytosolic Drug Delivery Triggered by Reactive Oxygen Species-Responsive Micelles

2016 ◽  
Vol 17 (9) ◽  
pp. 3040-3047 ◽  
Author(s):  
Lu-Yi Yu ◽  
Geng-Min Su ◽  
Chi-Kang Chen ◽  
Yi-Ting Chiang ◽  
Chun-Liang Lo
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Delivery ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Specific Cancer

scholarly journals Reactive oxygen species and enzyme dual-responsive biocompatible drug delivery system for targeted tumor therapy

2020 ◽  
Vol 324 ◽  
pp. 330-340 ◽  
Author(s):  
Ning Zhao ◽  
Bingbing Ding ◽  
Ying Zhang ◽  
Jessica L. Klockow ◽  
Ken Lau ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tumor Therapy ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Dual Responsive

scholarly journals Reactive Oxygen Species Responsive Polymers for Drug Delivery Systems

2021 ◽  
Vol 9 ◽  
Author(s):  
Fengxiang Gao ◽  
Zhengrong Xiong
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Delivery ◽  
Targeted Delivery ◽  
Reactive Oxygen ◽  
Molecular Structures ◽  
Chemical Mechanism ◽  
Oxygen Species ◽  
Polymer Carriers ◽  
Responsive Polymers ◽  
Responsive Polymer

Reactive oxygen species (ROS) play an essential role in regulating various physiological functions of living organisms; however, as the concentration of ROS increases in the area of a lesion, this may undermine cellular homeostasis, leading to a series of diseases. Using cell-product species as triggers for targeted regulation of polymer structures and activity represents a promising approach for the treatment. ROS-responsive polymer carriers allow the targeted delivery of drugs, reduce toxicity and side effects on normal cells, and control the release of drugs, which are all advantages compared with traditional small-molecule chemotherapy agents. These formulations have attracted great interest due to their potential applications in biomedicine. In this review, recent progresses on ROS responsive polymer carriers are summarized, with a focus on the chemical mechanism of ROS-responsive polymers and the design of molecular structures for targeted drug delivery and controlled drug release. Meanwhile, we discuss the challenges and future prospects of its applications.

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