scholarly journals Sonopermeation with Nanoparticle‐Stabilized Microbubbles Reduces Solid Stress and Improves Nanomedicine Delivery to Tumors

2021 ◽  
pp. 2100147
Author(s):  
Einar Sulheim ◽  
Ingunn Hanson ◽  
Sofie Snipstad ◽  
Krister Vikedal ◽  
Yrr Mørch ◽  
...  
Keyword(s):  
Solid Stress

scholarly journals Osmotic Regulation Is Required for Cancer Cell Survival under Solid Stress

2015 ◽  
Vol 109 (7) ◽  
pp. 1334-1337 ◽  
Author(s):  
Daniel J. McGrail ◽  
Kathleen M. McAndrews ◽  
Chandler P. Brandenburg ◽  
Nithin Ravikumar ◽  
Quang Minh N. Kieu ◽  
...  
Keyword(s):  
Cell Survival ◽  
Cancer Cell ◽  
Osmotic Regulation ◽  
Solid Stress ◽  
Cancer Cell Survival

Mathematical Modeling of a Solid–Liquid Mixture with Mass Exchange Between Constituents

2006 ◽  
Vol 11 (6) ◽  
pp. 575-595 ◽  
Author(s):  
L. Fusi ◽  
A. Farina ◽  
D. Ambrosi
Keyword(s):  
Mathematical Modeling ◽  
Liquid Mixture ◽  
Solid Phase ◽  
Deformation Gradient ◽  
Elastic Solid ◽  
Solid Deformation ◽  
Solid Stress ◽  
Phase Deformation ◽  
Mass Conversion ◽  
Solid Liquid

The mechanical behavior of a mixture composed by an elastic solid and a fluid that exchange mass is investigated. Both the liquid flow and the solid deformation depend on how the solid phase has increased (diminished) its mass, i.e. on the mass conversion between constituents. The model is developed introducing a decomposition of the solid phase deformation gradient. In particular, exploiting the criterion of maximization of the rate of entropy production, we determine an explicit evolution equation for the so-called growth tensor which involves directly the solid stress tensor. An example of a possible choice of the constitutive functions is also presented.

Cyclopamine treatment disrupts extracellular matrix and alleviates solid stress to improve nanomedicine delivery for pancreatic cancer

2018 ◽  
Vol 26 (10) ◽  
pp. 913-919 ◽  
Author(s):  
Bo Zhang ◽  
Honglan Wang ◽  
Ting Jiang ◽  
Kai Jin ◽  
Zimiao Luo ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Extracellular Matrix ◽  
Solid Stress

The emergence of solid stress as a potent biomechanical marker of tumour progression

2018 ◽  
Vol 2 (5) ◽  
pp. 739-749
Author(s):  
Alain Vella ◽  
Enanga M. Eko ◽  
Armando del Río Hernández
Keyword(s):  
Stromal Cells ◽  
Tumour Growth ◽  
Tumour Progression ◽  
Tissue Structure ◽  
Signalling Pathways ◽  
Matrix Stiffness ◽  
Cell Behaviour ◽  
Solid Stress ◽  
Comprehensive Knowledge ◽  
Macro Scale

Cancer is a disease of dysregulated mechanics which alters cell behaviour, compromises tissue structure, and promotes tumour growth and metastasis. In the context of tumour progression, the most widely studied of biomechanical markers is matrix stiffness as tumour tissue is typically stiffer than healthy tissue. However, solid stress has recently been identified as another marker of tumour growth, with findings strongly suggesting that its role in cancer is distinct from that of stiffness. Owing to the relative infancy of the field which draws from diverse disciplines, a comprehensive knowledge of the relationships between solid stress, tumorigenesis, and metastasis is likely to provide new and valuable insights. In this review, we discuss the micro- and macro-scale biomechanical interactions that give rise to solid stresses, and also examine the techniques developed to quantify solid stress within the tumour environment. Moreover, by reviewing the effects of solid stress on tissues, cancer and stromal cells, and signalling pathways, we also detail its mode of action at each level of the cancer cascade.

scholarly journals A New Poroelastography Method to Assess the Solid Stress Distribution in Cancers

IEEE Access ◽  
2019 ◽  
Vol 7 ◽  
pp. 103404-103415 ◽  
Author(s):  
Md Tauhidul Islam ◽  
Raffaella Righetti
Keyword(s):  
Stress Distribution ◽  
Solid Stress

scholarly journals MicroRNA-mRNA Interactions at Low Levels of Compressive Solid Stress Implicate mir-548 in Increased Glioblastoma Cell Motility

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Mark A. Calhoun ◽  
Yixiao Cui ◽  
Eileen E. Elliott ◽  
Xiaokui Mo ◽  
Jose J. Otero ◽  
...  
Keyword(s):  
Cell Motility ◽  
Glioblastoma Cell ◽  
Solid Stress ◽  
Low Levels
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