scholarly journals Human Ferritin Platform and Its Optimized Structures to Enhance Anti‐Cancer Immunity

2020 ◽  
pp. 2000208
Author(s):  
Bo‐Ram Lee ◽  
Hyo‐Jung Lee ◽  
June Huh ◽  
Chul Joo Yoon ◽  
Se Jin Oh ◽  
...  
Keyword(s):  
Cancer Immunity ◽  
Anti Cancer ◽  
Human Ferritin

scholarly journals Differential effects of zoledronic acid and oestrogen on anti-cancer immunity

Bone Reports ◽  
2021 ◽  
Vol 14 ◽  
pp. 101024
Author(s):  
Chris George ◽  
Diane Lefley ◽  
Victor Canuas-Landero ◽  
Claudia Tulotta ◽  
Hannah Corness ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Differential Effects ◽  
Cancer Immunity ◽  
Anti Cancer

scholarly journals Cytotoxic T-lymphocyte infiltration and chemokine predict long-term patient survival independently of tumor mutational burden in triple-negative breast cancer

2021 ◽  
Vol 13 ◽  
pp. 175883592110066
Author(s):  
Eriko Katsuta ◽  
Li Yan ◽  
Mateusz Opyrchal ◽  
Pawel Kalinski ◽  
Kazuaki Takabe
Keyword(s):  
Breast Cancer ◽  
Triple Negative ◽  
Patient Survival ◽  
Cytotoxic T Lymphocyte ◽  
Breast Cancer Patients ◽  
Mutational Burden ◽  
Cancer Immunity ◽  
Anti Cancer ◽  
Tumor Mutational Burden ◽  
Patient Prognosis

Background: Cytotoxic T-lymphocyte (CTL) infiltration into tumor is a positive prognostic factor in breast cancer. High tumor mutational burden (TMB) is also considered as a predictor of tumor immunogenicity and response to immunotherapy. However, it is unclear whether the infiltration of functional CTL simply reflects the TMB or represents an independent prognostic value. Methods: Utilizing The Cancer Genome Atlas (TCGA) breast cancer cohort, we established the Functional Hotness Score (FHS). The associations of FHS and breast cancer patient prognosis as well as distinct immunity markers were analyzed in a total of 3011 breast cancer patients using TCGA, METABRIC and metastatic breast cancer (MBC) cohort GSE110590. Results: We established FHS, based on CD8A, GZMB and CXCL10 gene expression levels of bulk tumors, which delivered the best prognostic value among some gene combinations. Breast cancer patients with the high-FHS tumors showed significantly better survival. FHS was lower in the MBCs. Triple-negative breast cancer (TNBC) showed the highest FHS among subtypes. FHS predicted patient survival in hormone receptor (HR)-negative, especially in TNBC, but not in HR-positive breast cancer. FHS predicted patient prognosis independently in TNBC. The high-FHS TNBCs showed not only higher CD8+ T cell infiltration, but also enhanced broader type-1 anti-cancer immunity. The patients with the high-FHS tumors showed better prognosis not only in high-TMB tumors but also in low-TMB TNBCs. The combination of high-TMB with high-FHS identified a unique subset of patients who do not recur over time in TNBC. Conclusion: TNBCs with high FHS based on the expression levels of CD8A, GZMB and CXCL10 showed improved prognosis with enhanced anti-cancer immunity regardless of TMB. FHS constitutes an independent prognostic marker of survival, particularly robustly when combined with TMB in TNBC.

Abstract 1384: Selective PI3Kγ inhibitor ZX-4081 reprograms the tumor microenvironment to facilitate anti-cancer immunity

2021 ◽  
Author(s):  
Ying-Ying Li ◽  
Kun Guo ◽  
Zhiyuan Peng ◽  
Deming Kong ◽  
Xiaolin Hao ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Immunity ◽  
Anti Cancer

INDUCTION OF ANTI-CANCER IMMUNITY WITH RNA

1973 ◽  
Vol 207 (1 RNA in the Im) ◽  
pp. 409-429 ◽  
Author(s):  
Yosef H. Pilch ◽  
Kenneth P. Ramming ◽  
Peter J. Deckers
Keyword(s):  
Cancer Immunity ◽  
Anti Cancer

Immunocytokines: amplification of anti-cancer immunity

2003 ◽  
Vol 52 (5) ◽  
pp. 297-308 ◽  
Author(s):  
Craig B. Davis ◽  
Stephen D. Gillies
Keyword(s):  
Cancer Immunity ◽  
Anti Cancer

Influences of different types of high fat diets on anti-cancer immunity in a murine carcinomatous peritonitis model

2018 ◽  
Vol 37 ◽  
pp. S75-S76
Author(s):  
A. Watkins ◽  
K. Fukatsu ◽  
T. Watanabe ◽  
K. Higashizono ◽  
S. Murakoshi ◽  
...  
Keyword(s):  
High Fat ◽  
Cancer Immunity ◽  
Anti Cancer ◽  
High Fat Diets ◽  
Different Types ◽  
Fat Diets ◽  
Peritonitis Model

scholarly journals Combination immunotherapy and active-specific tumor cell vaccination augments anti-cancer immunity in a mouse model of gastric cancer

2011 ◽  
Vol 9 (1) ◽  
Author(s):  
Natasja K van den Engel ◽  
Dominik Rüttinger ◽  
Margareta Rusan ◽  
Robert Kammerer ◽  
Wolfgang Zimmermann ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Mouse Model ◽  
Tumor Cell ◽  
Combination Immunotherapy ◽  
Cancer Immunity ◽  
Specific Tumor ◽  
Anti Cancer
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