A New Anti‐Immune Evasion Strategy against Methicillin‐Resistant Staphylococcus Aureus (MRSA) Infections: Simulating Complement Immunotherapy Based on Complement‐Mimic Antibiotic Delivery System

2020 ◽  
pp. 2000167
Author(s):  
Xucheng Hou ◽  
Wenxi Zhang ◽  
Yansha Meng ◽  
Wenkai Zhou ◽  
Guanghua Peng ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Delivery System ◽  
Immune Evasion ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Methicillin Resistant ◽  
Evasion Strategy ◽  
Antibiotic Delivery

scholarly journals Phage-Mediated Immune Evasion and Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus aureus in Humans

2020 ◽  
Vol 26 (11) ◽  
Author(s):  
Raphael N. Sieber ◽  
Tinna R. Urth ◽  
Andreas Petersen ◽  
Camilla H. Møller ◽  
Lance B. Price ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Immune Evasion ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Methicillin Resistant

scholarly journals Methicillin-Resistant Staphylococcus aureus from Peninsular Malaysian Animal Handlers: Molecular Profile, Antimicrobial Resistance, Immune Evasion Cluster and Genotypic Categorization

Antibiotics ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 103
Author(s):  
Minhian Chai ◽  
Muhammad Zikree Sukiman ◽  
Amirah Huda Kamarun Baharin ◽  
Insyirah Ramlan ◽  
Lennard Zhunhoong Lai ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Resistance ◽  
Immune Evasion ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Peninsular Malaysia ◽  
Molecular Techniques ◽  
Molecular Profile ◽  
Methicillin Resistant ◽  
Immune Evasion Cluster ◽  
Animal Handlers

Staphylococcus aureus (S. aureus) infections, particularly methicillin-resistant Staphylococcus aureus (MRSA) in humans and animals, have become a significant concern globally. The present study aimed to determine the prevalence and antibiogram of S. aureus isolated from animal handlers in Peninsular Malaysia. Furthermore, the genotypic characteristics of S. aureus isolates were also investigated. Nasal and oral swab samples were collected from 423 animal handlers in Peninsular Malaysia. The antibiogram profiles of S. aureus against 18 antibiotics were established using a Kirby–Bauer test. The genotypic profile of S. aureus, including the presence of antimicrobial resistance (AMR), virulence genes and spa genotypes, was investigated using molecular techniques. The overall carriage rate of S. aureus, MRSA and MDRSA was 30.5%, 1.2% and 19.4%, respectively. S. aureus was highly resistant against penicillin (72.3%) and amoxicillin (52.3%). Meanwhile, gentamicin and linezolid were fully effective against all the isolated S. aureus from animal handlers. It was observed that animal handlers with close exposure to poultry were more likely to carry S. aureus that is resistant to tetracycline and erythromycin. S. aureus isolates harboured tetracycline resistance (tetK, tetL and tetM), erythromycin resistance (ermA, ermB, ermC and msrA) and immune evasion cluster (IEC) genes (scn, chp, sak, sea and sep). Seventeen different spa types were detected among the 30 isolates of MDRSA, with t189 (16.7%) and t4171 (16.7%) being the predominant spa type, suggesting wide genetic diversity of the MDRSA isolates. The present study demonstrated the prevalence of S. aureus strains, including MRSA and MDRSA with various antimicrobial resistance and genetic profiles from animal handlers in Peninsular Malaysia.

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