Modularly Engineered Solid‐Phase Synthesis of Aptamer‐Functionalized Small Molecule Drugs for Targeted Cancer Therapy

2020 ◽  
Vol 3 (9) ◽  
pp. 2000074 ◽  
Author(s):  
Dan Wang ◽  
Yongbo Peng ◽  
Zhengyu Deng ◽  
Yan Tan ◽  
Yuanye Su ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Small Molecule ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Targeted Cancer Therapy ◽  
Phase Synthesis ◽  
Small Molecule Drugs

Screening of novel RGD peptides to modify nanoparticles for targeted cancer therapy

2018 ◽  
Vol 6 (1) ◽  
pp. 125-135 ◽  
Author(s):  
Liang Ge ◽  
Xinru You ◽  
Keqing Huang ◽  
Yang Kang ◽  
Yuejian Chen ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Carboxymethyl Chitosan ◽  
Targeted Cancer Therapy ◽  
Operating Environment ◽  
Rgd Peptides ◽  
Phase Synthesis ◽  
Molecular Operating Environment ◽  
Active Target

New targeted RGD peptides obtained by solid phase synthesis (SPPS) were successfully screened by Molecular Operating Environment (MOE) and used for the building of the 6-O-carboxymethyl chitosan based carrier with an active target on the surface.

Analytical Techniques for Small Molecule Solid Phase Synthesis

2002 ◽  
Vol 9 (23) ◽  
pp. 2103-2127 ◽  
Author(s):  
Jan Scicinski ◽  
Miles Congreve ◽  
Corinne Kay ◽  
Steven Ley
Keyword(s):  
Small Molecule ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Analytical Techniques ◽  
Phase Synthesis

Solid phase synthesis and SAR of small molecule agonists for the GPR40 receptor

2007 ◽  
Vol 17 (6) ◽  
pp. 1584-1589 ◽  
Author(s):  
Stephen C. McKeown ◽  
David F. Corbett ◽  
Aaron S. Goetz ◽  
Thomas R. Littleton ◽  
Eric Bigham ◽  
...  
Keyword(s):  
Small Molecule ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis

Facile one-step solid-phase synthesis of multitopic organic–DNA hybrids via “click” chemistry

2014 ◽  
Vol 5 (3) ◽  
pp. 1091-1096 ◽  
Author(s):  
Ryan V. Thaner ◽  
Ibrahim Eryazici ◽  
Omar K. Farha ◽  
Chad A. Mirkin ◽  
SonBinh T. Nguyen
Keyword(s):  
Click Chemistry ◽  
Small Molecule ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Solid Support ◽  
One Pot ◽  
Phase Synthesis ◽  
One Step

Small molecule–DNA hybrids can be synthesized in a one-pot fashion and in good yields by coupling multiazide cores to alkyne-modified DNAs on a solid support using click chemistry.

ChemInform Abstract: Preparation of Small Molecule Libraries for Agrochemical Discovery. Development of Parallel Solution and Solid Phase Synthesis Methods

ChemInform ◽  
2010 ◽  
Vol 32 (28) ◽  
pp. no-no
Author(s):  
Bruce C. Hamper ◽  
Thomas J. Owen ◽  
Kevin D. Jerome ◽  
Angela S. Scates ◽  
Stephen A. Kolodziej ◽  
...  
Keyword(s):  
Small Molecule ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Synthesis Methods ◽  
Phase Synthesis ◽  
Parallel Solution ◽  
Small Molecule Libraries
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